Association of lymphatic flow velocity with surgical outcomes in patients undergoing lymphovenous anastomosis for breast cancer-related lymphedema
Purpose Lymphovenous anastomosis (LVA) is primarily used for treating early-stage lymphedema. Here, we aimed to investigate the relationship between lymphatic flow velocity and the efficacy of LVA in breast cancer-related lymphedema patients. To this end, we assessed the transit velocity of lymphati...
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| Veröffentlicht in: | Breast cancer (Tokyo, Japan) Japan), 2022-09, Vol.29 (5), p.835-843 |
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| creator | Park, Joseph Kyu-hyung Seo, Junggyo Yang, Eun Joo Kang, Yusuhn Heo, Chan Yeong Myung, Yujin |
| description | Purpose
Lymphovenous anastomosis (LVA) is primarily used for treating early-stage lymphedema. Here, we aimed to investigate the relationship between lymphatic flow velocity and the efficacy of LVA in breast cancer-related lymphedema patients. To this end, we assessed the transit velocity of lymphatic fluid using indocyanine green (ICG) lymphography and radioisotope lymphoscintigraphy.
Methods
We retrospectively examined patients diagnosed with breast cancer-related lymphedema who underwent LVA from January to December 2020. Patient data, including demographics, clinical stage, and postoperative surgical outcomes, were collected from electronic medical records. ICG lymphography results and dynamic lymphoscintigrams were analyzed to measure the lymphatic flow velocity and to determine the grade of the limb lymphedemas.
Results
Eighty patients (all female, mean age of 53.6 years) were included. The lymphatic flow velocity ranged between 0.58 and 21.5 cm/min (average, 7.61 cm/min); 37 (46.3%), 18 (22.5%), 15 (18.8%), and 10 (12.5%) arm lymphedemas were classified as lymphoscintigraphy grade 0, 1, 2, and 3, respectively. A significant association was observed between lymphatic flow velocity and lymphedema grade determined using lymphoscintigraphy and between the amount of volume reduction after LVA and preoperative lymphatic flow velocity (
P
|
| doi_str_mv | 10.1007/s12282-022-01363-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2664793345</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714262910</galeid><sourcerecordid>A714262910</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-1ab6a2d8c2446fe0e2e57b153228f2f0c1f352ade31e4d58e5c8ef07851637bb3</originalsourceid><addsrcrecordid>eNp9kV1rFTEQhhdRbK3-AS8k4I03W_O9OZeHUj-g4I1eh2x2sk3JJsck23L6M_zFpm4VBJEQksw87zCZt-teE3xOMB7eF0Kpoj2mbRMmWX__pDslSuGeU8aetjvjuJdKqpPuRSk3GHM2YPm8O2FCCIbJ7rT7sS8lWW-qTxElh8JxOVy3l0UupDt0C6Fl6xHd-XqNyppnb01Aaa02LVCQj-jQaIi1oDVOkOfk47xVSbcQ01qQiabUtKTiC3IpozFDCyBrooXcZwimwrRJYILFvOyeORMKvHo8z7pvHy6_Xnzqr758_Hyxv-otk6r2xIzS0ElZyrl0gIGCGEYiWBuKow5b4pigZgJGgE9CgbAKHB6UIJIN48jOundb3UNO31coVS--WAjBRGh9ayolH3aMcdHQtxs6mwDaR5dqNvYB1_uBcCrpjuBGnf-Daqv9ytsUwfkW_0tAN4HNqZQMTh-yX0w-aoL1g8V6s1g3i_Uvi_V9E715bHsdF5j-SH572gC2AaWl4gxZ36Q1xzbK_5X9CcBmtVw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2664793345</pqid></control><display><type>article</type><title>Association of lymphatic flow velocity with surgical outcomes in patients undergoing lymphovenous anastomosis for breast cancer-related lymphedema</title><source>SpringerLink Journals - AutoHoldings</source><creator>Park, Joseph Kyu-hyung ; Seo, Junggyo ; Yang, Eun Joo ; Kang, Yusuhn ; Heo, Chan Yeong ; Myung, Yujin</creator><creatorcontrib>Park, Joseph Kyu-hyung ; Seo, Junggyo ; Yang, Eun Joo ; Kang, Yusuhn ; Heo, Chan Yeong ; Myung, Yujin</creatorcontrib><description>Purpose
Lymphovenous anastomosis (LVA) is primarily used for treating early-stage lymphedema. Here, we aimed to investigate the relationship between lymphatic flow velocity and the efficacy of LVA in breast cancer-related lymphedema patients. To this end, we assessed the transit velocity of lymphatic fluid using indocyanine green (ICG) lymphography and radioisotope lymphoscintigraphy.
Methods
We retrospectively examined patients diagnosed with breast cancer-related lymphedema who underwent LVA from January to December 2020. Patient data, including demographics, clinical stage, and postoperative surgical outcomes, were collected from electronic medical records. ICG lymphography results and dynamic lymphoscintigrams were analyzed to measure the lymphatic flow velocity and to determine the grade of the limb lymphedemas.
Results
Eighty patients (all female, mean age of 53.6 years) were included. The lymphatic flow velocity ranged between 0.58 and 21.5 cm/min (average, 7.61 cm/min); 37 (46.3%), 18 (22.5%), 15 (18.8%), and 10 (12.5%) arm lymphedemas were classified as lymphoscintigraphy grade 0, 1, 2, and 3, respectively. A significant association was observed between lymphatic flow velocity and lymphedema grade determined using lymphoscintigraphy and between the amount of volume reduction after LVA and preoperative lymphatic flow velocity (
P
< 0.05).
Conclusions
Our findings suggest that lymphatic flow velocity is positively correlated with surgical outcomes in patients undergoing LVA. Therefore, surgical treatment plans for lymphedema should not be based only on the International Society of Lymphedema stage, because advanced-stage lymphedema patients with high ICG velocities can benefit from LVA alone.</description><identifier>ISSN: 1340-6868</identifier><identifier>EISSN: 1880-4233</identifier><identifier>DOI: 10.1007/s12282-022-01363-z</identifier><identifier>PMID: 35553019</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Analysis ; Breast cancer ; Cancer patients ; Cancer Research ; Health aspects ; Lymphedema ; Medical records ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Patient outcomes ; Surgery ; Surgical Oncology ; Trade and professional associations ; Women</subject><ispartof>Breast cancer (Tokyo, Japan), 2022-09, Vol.29 (5), p.835-843</ispartof><rights>The Author(s), under exclusive licence to The Japanese Breast Cancer Society 2022</rights><rights>2022. The Author(s), under exclusive licence to The Japanese Breast Cancer Society.</rights><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-1ab6a2d8c2446fe0e2e57b153228f2f0c1f352ade31e4d58e5c8ef07851637bb3</citedby><cites>FETCH-LOGICAL-c368t-1ab6a2d8c2446fe0e2e57b153228f2f0c1f352ade31e4d58e5c8ef07851637bb3</cites><orcidid>0000-0001-7478-7051 ; 0000-0002-0812-6228 ; 0000-0003-1838-2564 ; 0000-0001-9003-7365 ; 0000-0001-5051-2440 ; 0000-0003-2417-2416</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12282-022-01363-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12282-022-01363-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35553019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Joseph Kyu-hyung</creatorcontrib><creatorcontrib>Seo, Junggyo</creatorcontrib><creatorcontrib>Yang, Eun Joo</creatorcontrib><creatorcontrib>Kang, Yusuhn</creatorcontrib><creatorcontrib>Heo, Chan Yeong</creatorcontrib><creatorcontrib>Myung, Yujin</creatorcontrib><title>Association of lymphatic flow velocity with surgical outcomes in patients undergoing lymphovenous anastomosis for breast cancer-related lymphedema</title><title>Breast cancer (Tokyo, Japan)</title><addtitle>Breast Cancer</addtitle><addtitle>Breast Cancer</addtitle><description>Purpose
Lymphovenous anastomosis (LVA) is primarily used for treating early-stage lymphedema. Here, we aimed to investigate the relationship between lymphatic flow velocity and the efficacy of LVA in breast cancer-related lymphedema patients. To this end, we assessed the transit velocity of lymphatic fluid using indocyanine green (ICG) lymphography and radioisotope lymphoscintigraphy.
Methods
We retrospectively examined patients diagnosed with breast cancer-related lymphedema who underwent LVA from January to December 2020. Patient data, including demographics, clinical stage, and postoperative surgical outcomes, were collected from electronic medical records. ICG lymphography results and dynamic lymphoscintigrams were analyzed to measure the lymphatic flow velocity and to determine the grade of the limb lymphedemas.
Results
Eighty patients (all female, mean age of 53.6 years) were included. The lymphatic flow velocity ranged between 0.58 and 21.5 cm/min (average, 7.61 cm/min); 37 (46.3%), 18 (22.5%), 15 (18.8%), and 10 (12.5%) arm lymphedemas were classified as lymphoscintigraphy grade 0, 1, 2, and 3, respectively. A significant association was observed between lymphatic flow velocity and lymphedema grade determined using lymphoscintigraphy and between the amount of volume reduction after LVA and preoperative lymphatic flow velocity (
P
< 0.05).
Conclusions
Our findings suggest that lymphatic flow velocity is positively correlated with surgical outcomes in patients undergoing LVA. Therefore, surgical treatment plans for lymphedema should not be based only on the International Society of Lymphedema stage, because advanced-stage lymphedema patients with high ICG velocities can benefit from LVA alone.</description><subject>Analysis</subject><subject>Breast cancer</subject><subject>Cancer patients</subject><subject>Cancer Research</subject><subject>Health aspects</subject><subject>Lymphedema</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Patient outcomes</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Trade and professional associations</subject><subject>Women</subject><issn>1340-6868</issn><issn>1880-4233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kV1rFTEQhhdRbK3-AS8k4I03W_O9OZeHUj-g4I1eh2x2sk3JJsck23L6M_zFpm4VBJEQksw87zCZt-teE3xOMB7eF0Kpoj2mbRMmWX__pDslSuGeU8aetjvjuJdKqpPuRSk3GHM2YPm8O2FCCIbJ7rT7sS8lWW-qTxElh8JxOVy3l0UupDt0C6Fl6xHd-XqNyppnb01Aaa02LVCQj-jQaIi1oDVOkOfk47xVSbcQ01qQiabUtKTiC3IpozFDCyBrooXcZwimwrRJYILFvOyeORMKvHo8z7pvHy6_Xnzqr758_Hyxv-otk6r2xIzS0ElZyrl0gIGCGEYiWBuKow5b4pigZgJGgE9CgbAKHB6UIJIN48jOundb3UNO31coVS--WAjBRGh9ayolH3aMcdHQtxs6mwDaR5dqNvYB1_uBcCrpjuBGnf-Daqv9ytsUwfkW_0tAN4HNqZQMTh-yX0w-aoL1g8V6s1g3i_Uvi_V9E715bHsdF5j-SH572gC2AaWl4gxZ36Q1xzbK_5X9CcBmtVw</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Park, Joseph Kyu-hyung</creator><creator>Seo, Junggyo</creator><creator>Yang, Eun Joo</creator><creator>Kang, Yusuhn</creator><creator>Heo, Chan Yeong</creator><creator>Myung, Yujin</creator><general>Springer Nature Singapore</general><general>Springer</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7478-7051</orcidid><orcidid>https://orcid.org/0000-0002-0812-6228</orcidid><orcidid>https://orcid.org/0000-0003-1838-2564</orcidid><orcidid>https://orcid.org/0000-0001-9003-7365</orcidid><orcidid>https://orcid.org/0000-0001-5051-2440</orcidid><orcidid>https://orcid.org/0000-0003-2417-2416</orcidid></search><sort><creationdate>20220901</creationdate><title>Association of lymphatic flow velocity with surgical outcomes in patients undergoing lymphovenous anastomosis for breast cancer-related lymphedema</title><author>Park, Joseph Kyu-hyung ; Seo, Junggyo ; Yang, Eun Joo ; Kang, Yusuhn ; Heo, Chan Yeong ; Myung, Yujin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-1ab6a2d8c2446fe0e2e57b153228f2f0c1f352ade31e4d58e5c8ef07851637bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Breast cancer</topic><topic>Cancer patients</topic><topic>Cancer Research</topic><topic>Health aspects</topic><topic>Lymphedema</topic><topic>Medical records</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Patient outcomes</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Trade and professional associations</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Joseph Kyu-hyung</creatorcontrib><creatorcontrib>Seo, Junggyo</creatorcontrib><creatorcontrib>Yang, Eun Joo</creatorcontrib><creatorcontrib>Kang, Yusuhn</creatorcontrib><creatorcontrib>Heo, Chan Yeong</creatorcontrib><creatorcontrib>Myung, Yujin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Joseph Kyu-hyung</au><au>Seo, Junggyo</au><au>Yang, Eun Joo</au><au>Kang, Yusuhn</au><au>Heo, Chan Yeong</au><au>Myung, Yujin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of lymphatic flow velocity with surgical outcomes in patients undergoing lymphovenous anastomosis for breast cancer-related lymphedema</atitle><jtitle>Breast cancer (Tokyo, Japan)</jtitle><stitle>Breast Cancer</stitle><addtitle>Breast Cancer</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>29</volume><issue>5</issue><spage>835</spage><epage>843</epage><pages>835-843</pages><issn>1340-6868</issn><eissn>1880-4233</eissn><abstract>Purpose
Lymphovenous anastomosis (LVA) is primarily used for treating early-stage lymphedema. Here, we aimed to investigate the relationship between lymphatic flow velocity and the efficacy of LVA in breast cancer-related lymphedema patients. To this end, we assessed the transit velocity of lymphatic fluid using indocyanine green (ICG) lymphography and radioisotope lymphoscintigraphy.
Methods
We retrospectively examined patients diagnosed with breast cancer-related lymphedema who underwent LVA from January to December 2020. Patient data, including demographics, clinical stage, and postoperative surgical outcomes, were collected from electronic medical records. ICG lymphography results and dynamic lymphoscintigrams were analyzed to measure the lymphatic flow velocity and to determine the grade of the limb lymphedemas.
Results
Eighty patients (all female, mean age of 53.6 years) were included. The lymphatic flow velocity ranged between 0.58 and 21.5 cm/min (average, 7.61 cm/min); 37 (46.3%), 18 (22.5%), 15 (18.8%), and 10 (12.5%) arm lymphedemas were classified as lymphoscintigraphy grade 0, 1, 2, and 3, respectively. A significant association was observed between lymphatic flow velocity and lymphedema grade determined using lymphoscintigraphy and between the amount of volume reduction after LVA and preoperative lymphatic flow velocity (
P
< 0.05).
Conclusions
Our findings suggest that lymphatic flow velocity is positively correlated with surgical outcomes in patients undergoing LVA. Therefore, surgical treatment plans for lymphedema should not be based only on the International Society of Lymphedema stage, because advanced-stage lymphedema patients with high ICG velocities can benefit from LVA alone.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>35553019</pmid><doi>10.1007/s12282-022-01363-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7478-7051</orcidid><orcidid>https://orcid.org/0000-0002-0812-6228</orcidid><orcidid>https://orcid.org/0000-0003-1838-2564</orcidid><orcidid>https://orcid.org/0000-0001-9003-7365</orcidid><orcidid>https://orcid.org/0000-0001-5051-2440</orcidid><orcidid>https://orcid.org/0000-0003-2417-2416</orcidid></addata></record> |
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| identifier | ISSN: 1340-6868 |
| ispartof | Breast cancer (Tokyo, Japan), 2022-09, Vol.29 (5), p.835-843 |
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| subjects | Analysis Breast cancer Cancer patients Cancer Research Health aspects Lymphedema Medical records Medicine Medicine & Public Health Oncology Original Article Patient outcomes Surgery Surgical Oncology Trade and professional associations Women |
| title | Association of lymphatic flow velocity with surgical outcomes in patients undergoing lymphovenous anastomosis for breast cancer-related lymphedema |
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