UDP/P2Y6 contributes to enhancing LPS-induced acute lung injury by regulating neutrophil migration

•GPCR receptor-P2Y6 was involved in mediating innate immune response in ALI process.•P2Y6 on neutrophil contributed to the of neutrophil infiltrating into lung tissues in ALI.•P2Y6 mediated neutrophil migration through cytoskeleton F-actin remodeling via ERK signaling pathway.•Deficiency of P2Y6 all...

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Veröffentlicht in:	Cellular immunology 2022-06, Vol.376, p.104530-104530, Article 104530
Hauptverfasser:	Fu, Zhixiang, Chen, Jie, Zhang, Ran, Qin, Juliang, Shi, Jueping, Zhang, Xiaoyu, Du, Bing, Qian, Min, Ren, Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lung injury Neutrophil migration P2Y6 Pulmonary inflammation UDP
Online-Zugang:	Volltext
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