Assessment of redox state and biochemical parameters of salivary glands in rats treated with anti-obesity drug sibutramine hydrochloride
Objectives To investigate the effects of anti-obesity drug sibutramine hydrochloride (SB) on redox state and biochemical parameters in the salivary glands. Materials and methods Adult male Wistar rats were randomly divided into the following groups ( n = 8 per group): control rats treated with vehi...
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| Veröffentlicht in: | Clinical oral investigations 2022-09, Vol.26 (9), p.5833-5846 |
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| creator | dos Santos, Damáris Raissa Fiais, Gabriela Alice Oliveira, Henrique Arnaldo Ribas, Tayná Buffulin Souza, Rayne Oliveira Tsosura, Thaís Verônica Saori Matsushita, Doris Hissako Ervolino, Edilson Dornelles, Rita Cássia Menegati Nakamune, Ana Cláudia de Melo Stevanato Chaves-Neto, Antonio Hernandes |
| description | Objectives
To investigate the effects of anti-obesity drug sibutramine hydrochloride (SB) on redox state and biochemical parameters in the salivary glands.
Materials and methods
Adult male Wistar rats were randomly divided into the following groups (
n
= 8 per group): control rats treated with vehicle (C) and rats treated with SB (10 mg/kg/day) by intragastric gavage for 28 days. The parotid (PG) and submandibular (SMG) glands were processed using histomorphometric analysis, and total protein, amylase, mucin, and oxidative damage to lipids were determined by measuring the formation of thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), uric acid (UA), total glutathione (tGSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and AKT phosphorylation.
Results
SB decreased the acinar area, and increased the stromal area in PG, while no effect on the morphometric parameters was observed in SMG. SB also increased oxidative damage to lipids (TBARs). The SB group showed lower total protein, amylase, TAC, UA, tGSH, SOD, CAT, and GPx than the C group in PG, while in SMG, SB decreased total protein, mucin, tGSH, SOD, CAT, and GPx. However, increased AKT phosphorylation observed in both salivary glands suggests that SB exerts low-intensity oxidative stress.
Conclusions
SB impaired enzymatic and non-enzymatic antioxidant defenses in the salivary glands of rats.
Clinical relevance
Chronic treatment with SB could mitigate salivary gland dysfunction due to disturbance of redox state. |
| doi_str_mv | 10.1007/s00784-022-04539-1 |
| format | Article |
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To investigate the effects of anti-obesity drug sibutramine hydrochloride (SB) on redox state and biochemical parameters in the salivary glands.
Materials and methods
Adult male Wistar rats were randomly divided into the following groups (
n
= 8 per group): control rats treated with vehicle (C) and rats treated with SB (10 mg/kg/day) by intragastric gavage for 28 days. The parotid (PG) and submandibular (SMG) glands were processed using histomorphometric analysis, and total protein, amylase, mucin, and oxidative damage to lipids were determined by measuring the formation of thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), uric acid (UA), total glutathione (tGSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and AKT phosphorylation.
Results
SB decreased the acinar area, and increased the stromal area in PG, while no effect on the morphometric parameters was observed in SMG. SB also increased oxidative damage to lipids (TBARs). The SB group showed lower total protein, amylase, TAC, UA, tGSH, SOD, CAT, and GPx than the C group in PG, while in SMG, SB decreased total protein, mucin, tGSH, SOD, CAT, and GPx. However, increased AKT phosphorylation observed in both salivary glands suggests that SB exerts low-intensity oxidative stress.
Conclusions
SB impaired enzymatic and non-enzymatic antioxidant defenses in the salivary glands of rats.
Clinical relevance
Chronic treatment with SB could mitigate salivary gland dysfunction due to disturbance of redox state.</description><identifier>ISSN: 1436-3771</identifier><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-022-04539-1</identifier><identifier>PMID: 35556176</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>AKT protein ; Antioxidants ; Catalase ; Dentistry ; Exocrine glands ; Glutathione peroxidase ; Lipids ; Medicine ; Mucin ; Obesity ; Original Article ; Oxidative stress ; Parotid gland ; Phosphorylation ; Proteins ; Redox properties ; Rodents ; Salivary gland ; Sibutramine ; Submandibular gland ; Superoxide dismutase ; Thiobarbituric acid ; Uric acid</subject><ispartof>Clinical oral investigations, 2022-09, Vol.26 (9), p.5833-5846</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-64d93c37ff08efb84f6c5c9168e3b5876a3875e2cedd01854a48e3d3534241913</citedby><cites>FETCH-LOGICAL-c305t-64d93c37ff08efb84f6c5c9168e3b5876a3875e2cedd01854a48e3d3534241913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-022-04539-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-022-04539-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35556176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>dos Santos, Damáris Raissa</creatorcontrib><creatorcontrib>Fiais, Gabriela Alice</creatorcontrib><creatorcontrib>Oliveira, Henrique Arnaldo</creatorcontrib><creatorcontrib>Ribas, Tayná Buffulin</creatorcontrib><creatorcontrib>Souza, Rayne Oliveira</creatorcontrib><creatorcontrib>Tsosura, Thaís Verônica Saori</creatorcontrib><creatorcontrib>Matsushita, Doris Hissako</creatorcontrib><creatorcontrib>Ervolino, Edilson</creatorcontrib><creatorcontrib>Dornelles, Rita Cássia Menegati</creatorcontrib><creatorcontrib>Nakamune, Ana Cláudia de Melo Stevanato</creatorcontrib><creatorcontrib>Chaves-Neto, Antonio Hernandes</creatorcontrib><title>Assessment of redox state and biochemical parameters of salivary glands in rats treated with anti-obesity drug sibutramine hydrochloride</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objectives
To investigate the effects of anti-obesity drug sibutramine hydrochloride (SB) on redox state and biochemical parameters in the salivary glands.
Materials and methods
Adult male Wistar rats were randomly divided into the following groups (
n
= 8 per group): control rats treated with vehicle (C) and rats treated with SB (10 mg/kg/day) by intragastric gavage for 28 days. The parotid (PG) and submandibular (SMG) glands were processed using histomorphometric analysis, and total protein, amylase, mucin, and oxidative damage to lipids were determined by measuring the formation of thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), uric acid (UA), total glutathione (tGSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and AKT phosphorylation.
Results
SB decreased the acinar area, and increased the stromal area in PG, while no effect on the morphometric parameters was observed in SMG. SB also increased oxidative damage to lipids (TBARs). The SB group showed lower total protein, amylase, TAC, UA, tGSH, SOD, CAT, and GPx than the C group in PG, while in SMG, SB decreased total protein, mucin, tGSH, SOD, CAT, and GPx. However, increased AKT phosphorylation observed in both salivary glands suggests that SB exerts low-intensity oxidative stress.
Conclusions
SB impaired enzymatic and non-enzymatic antioxidant defenses in the salivary glands of rats.
Clinical relevance
Chronic treatment with SB could mitigate salivary gland dysfunction due to disturbance of redox state.</description><subject>AKT protein</subject><subject>Antioxidants</subject><subject>Catalase</subject><subject>Dentistry</subject><subject>Exocrine glands</subject><subject>Glutathione peroxidase</subject><subject>Lipids</subject><subject>Medicine</subject><subject>Mucin</subject><subject>Obesity</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Parotid gland</subject><subject>Phosphorylation</subject><subject>Proteins</subject><subject>Redox properties</subject><subject>Rodents</subject><subject>Salivary gland</subject><subject>Sibutramine</subject><subject>Submandibular gland</subject><subject>Superoxide dismutase</subject><subject>Thiobarbituric acid</subject><subject>Uric acid</subject><issn>1436-3771</issn><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kctu1DAUhi1ERS_wAiyQJTZsQu34liyrCihSJTZlbTn2yYyrJB58HGDegMfGw5SLWHRjWzqfPx-fn5CXnL3ljJlLrEsnG9a2DZNK9A1_Qs64FLoRxvCn_5xPyTniPWNcaiOekVOhlNLc6DPy4woREGdYCk0jzRDSd4rFFaBuCXSIyW9hjt5NdOeym6FAxgOJbopfXd7TzVRBpHGh2RWkJUO9HOi3WLZVUWKTBsBY9jTkdUMxDmupnrgA3e5Drvop5RjgOTkZ3YTw4mG_IJ_fv7u7vmluP334eH1123jBVGm0DL3wwowj62AcOjlqr3zPdQdiUJ3RTnRGQeshBMY7JZ2slSCUkK3kPRcX5M3Ru8vpywpY7BzRw1R_AWlF22ot61SZ7iv6-j_0Pq15qd3Z1vBqY71RlWqPlM8JMcNodznOdTKWM3vIyR5zsjUn-ysne-ji1YN6HWYIf678DqYC4ghgLS0byH_ffkT7E8SUn8g</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>dos Santos, Damáris Raissa</creator><creator>Fiais, Gabriela Alice</creator><creator>Oliveira, Henrique Arnaldo</creator><creator>Ribas, Tayná Buffulin</creator><creator>Souza, Rayne Oliveira</creator><creator>Tsosura, Thaís Verônica Saori</creator><creator>Matsushita, Doris Hissako</creator><creator>Ervolino, Edilson</creator><creator>Dornelles, Rita Cássia Menegati</creator><creator>Nakamune, Ana Cláudia de Melo Stevanato</creator><creator>Chaves-Neto, Antonio Hernandes</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220901</creationdate><title>Assessment of redox state and biochemical parameters of salivary glands in rats treated with anti-obesity drug sibutramine hydrochloride</title><author>dos Santos, Damáris Raissa ; Fiais, Gabriela Alice ; Oliveira, Henrique Arnaldo ; Ribas, Tayná Buffulin ; Souza, Rayne Oliveira ; Tsosura, Thaís Verônica Saori ; Matsushita, Doris Hissako ; Ervolino, Edilson ; Dornelles, Rita Cássia Menegati ; Nakamune, Ana Cláudia de Melo Stevanato ; Chaves-Neto, Antonio Hernandes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-64d93c37ff08efb84f6c5c9168e3b5876a3875e2cedd01854a48e3d3534241913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>AKT protein</topic><topic>Antioxidants</topic><topic>Catalase</topic><topic>Dentistry</topic><topic>Exocrine glands</topic><topic>Glutathione peroxidase</topic><topic>Lipids</topic><topic>Medicine</topic><topic>Mucin</topic><topic>Obesity</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Parotid gland</topic><topic>Phosphorylation</topic><topic>Proteins</topic><topic>Redox properties</topic><topic>Rodents</topic><topic>Salivary gland</topic><topic>Sibutramine</topic><topic>Submandibular gland</topic><topic>Superoxide dismutase</topic><topic>Thiobarbituric acid</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>dos Santos, Damáris Raissa</creatorcontrib><creatorcontrib>Fiais, Gabriela Alice</creatorcontrib><creatorcontrib>Oliveira, Henrique Arnaldo</creatorcontrib><creatorcontrib>Ribas, Tayná Buffulin</creatorcontrib><creatorcontrib>Souza, Rayne Oliveira</creatorcontrib><creatorcontrib>Tsosura, Thaís Verônica Saori</creatorcontrib><creatorcontrib>Matsushita, Doris Hissako</creatorcontrib><creatorcontrib>Ervolino, Edilson</creatorcontrib><creatorcontrib>Dornelles, Rita Cássia Menegati</creatorcontrib><creatorcontrib>Nakamune, Ana Cláudia de Melo Stevanato</creatorcontrib><creatorcontrib>Chaves-Neto, Antonio Hernandes</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>dos Santos, Damáris Raissa</au><au>Fiais, Gabriela Alice</au><au>Oliveira, Henrique Arnaldo</au><au>Ribas, Tayná Buffulin</au><au>Souza, Rayne Oliveira</au><au>Tsosura, Thaís Verônica Saori</au><au>Matsushita, Doris Hissako</au><au>Ervolino, Edilson</au><au>Dornelles, Rita Cássia Menegati</au><au>Nakamune, Ana Cláudia de Melo Stevanato</au><au>Chaves-Neto, Antonio Hernandes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of redox state and biochemical parameters of salivary glands in rats treated with anti-obesity drug sibutramine hydrochloride</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>26</volume><issue>9</issue><spage>5833</spage><epage>5846</epage><pages>5833-5846</pages><issn>1436-3771</issn><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objectives
To investigate the effects of anti-obesity drug sibutramine hydrochloride (SB) on redox state and biochemical parameters in the salivary glands.
Materials and methods
Adult male Wistar rats were randomly divided into the following groups (
n
= 8 per group): control rats treated with vehicle (C) and rats treated with SB (10 mg/kg/day) by intragastric gavage for 28 days. The parotid (PG) and submandibular (SMG) glands were processed using histomorphometric analysis, and total protein, amylase, mucin, and oxidative damage to lipids were determined by measuring the formation of thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), uric acid (UA), total glutathione (tGSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and AKT phosphorylation.
Results
SB decreased the acinar area, and increased the stromal area in PG, while no effect on the morphometric parameters was observed in SMG. SB also increased oxidative damage to lipids (TBARs). The SB group showed lower total protein, amylase, TAC, UA, tGSH, SOD, CAT, and GPx than the C group in PG, while in SMG, SB decreased total protein, mucin, tGSH, SOD, CAT, and GPx. However, increased AKT phosphorylation observed in both salivary glands suggests that SB exerts low-intensity oxidative stress.
Conclusions
SB impaired enzymatic and non-enzymatic antioxidant defenses in the salivary glands of rats.
Clinical relevance
Chronic treatment with SB could mitigate salivary gland dysfunction due to disturbance of redox state.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35556176</pmid><doi>10.1007/s00784-022-04539-1</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical oral investigations, 2022-09, Vol.26 (9), p.5833-5846 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | AKT protein Antioxidants Catalase Dentistry Exocrine glands Glutathione peroxidase Lipids Medicine Mucin Obesity Original Article Oxidative stress Parotid gland Phosphorylation Proteins Redox properties Rodents Salivary gland Sibutramine Submandibular gland Superoxide dismutase Thiobarbituric acid Uric acid |
| title | Assessment of redox state and biochemical parameters of salivary glands in rats treated with anti-obesity drug sibutramine hydrochloride |
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