COMPARE LAAO: Rationale and design of the randomized controlled trial “COMPARing Effectiveness and safety of Left Atrial Appendage Occlusion to standard of care for atrial fibrillation patients at high stroke risk and ineligible to use oral anticoagulation therapy”

Left atrial appendage occlusion (LAAO) provides an alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF). In patients with a long-term or permanent contraindication for OAC randomized controlled trial (RCT) data is lacking. To assess the efficacy a...

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Veröffentlicht in:	The American heart journal 2022-08, Vol.250, p.45-56
Hauptverfasser:	Huijboom, Marina, Maarse, Moniek, Aarnink, Errol, van Dijk, Vincent, Swaans, Martin, van der Heijden, Jeroen, IJsselmuiden, Sander, Folkeringa, Richard, Blaauw, Yuri, Elvan, Arif, Stevenhagen, Jeroen, Vlachojannis, George, van der Voort, Pepijn, Westra, Sjoerd, Chaldoupi, Marisevi, Khan, Muchtiar, de Groot, Joris, van der Kley, Frank, van Mieghem, Nicolas, van Dijk, Ewoud, Dijkgraaf, Marcel, Tijssen, Jan, Boersma, Lucas
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants Atrial Appendage - surgery Atrial Fibrillation - complications Atrial Fibrillation - drug therapy Blood clots Cardiac arrhythmia Complications Contraindications Cost analysis Decision analysis Decision making Design Effectiveness Embolism Female Fibrillation Health risks Health services Heart surgery Hemorrhage Humans Impact analysis Ischemia Male Occlusion Patients Population Risk Safety Standard of Care Stroke Stroke - complications Stroke - prevention & control Therapy Thromboembolism Thromboembolism - etiology Thromboembolism - prevention & control Transient ischemic attack Treatment Outcome
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