Histologic characterization of paediatric mesenchymal neoplasms treated with kinase‐targeted therapy

Aims Recurrent alterations involving receptor tyrosine or cytoplasmic kinase genes have been described in soft‐tissue neoplasms such as infantile fibrosarcoma (IFS) and inflammatory myofibroblastic tumour (IMT). Recent trials and regulatory approvals for targeted inhibitors against the kinase domain...

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Veröffentlicht in:	Histopathology 2022-08, Vol.81 (2), p.215-227
Hauptverfasser:	Baranov, Esther, Winsnes, Katrina, O'Brien, Matthew, Voss, Stephan D, Church, Alanna J, Janeway, Katherine A, DuBois, Steven G, Davis, Jessica L, Al‐Ibraheemi, Alyaa
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical trials Collagen crizotinib Fibrosarcoma Inflammation kinase alteration kinase fusion larotrectinib MEK inhibitors Mesenchyme Neoplasia Pediatrics Protein-tyrosine kinase Ran-binding protein sarcoma soft‐tissue tumours Stroma targeted therapy trametinib Tumors Viscera
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