Keratinocyte EGF signalling dominates in atopic dermatitis lesions: A comparative RNAseq analysis

Atopic dermatitis (AD) remains a highly heterogenous disorder with a multifactorial aetiology. Whilst keratinocytes are known to play a fundamental role in AD, their contribution to the overall immune landscape in moderate‐to‐severe AD is still poorly understood. In order to design new therapeutics,...

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Veröffentlicht in:	Experimental dermatology 2022-09, Vol.31 (9), p.1373-1384
Hauptverfasser:	Timms, Kate, Guo, Hui, Arkwright, Peter, Pennock, Joanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Atopic dermatitis Chemotaxis Dermatitis eczema Immunomodulation immunopathology Immunotherapy inflammation Interleukin 4 receptors Keratinocytes Signal transduction skin Skin diseases Th2
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