A facile protocol for the preparation of 2-carboxylated thieno [2,3- b ] indoles: a de novo access to alkaloid thienodolin
A metal-free strategy, alternative to the known complex cycloaddition reactions, towards 2-carboxylated thieno [2,3- ] indole derivatives has been successfully developed. The novel approach involves as starting materials easy accessible 1,2-diaza-1,3-dienes and indoline 2-thione and requires mild re...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2022-05, Vol.20 (20), p.4167-4175 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Mari, Giacomo De Crescentini, Lucia Favi, Gianfranco Santeusanio, Stefania Mantellini, Fabio |
| description | A metal-free strategy, alternative to the known complex cycloaddition reactions, towards 2-carboxylated thieno [2,3-
] indole derivatives has been successfully developed. The novel approach involves as starting materials easy accessible 1,2-diaza-1,3-dienes and indoline 2-thione and requires mild reaction conditions. Furthermore, the easy work-up required makes this method amenable for a one-pot approach as demonstrated in the preparation of thienodolin, a natural product isolated from
that exhibits valuable biological properties. |
| doi_str_mv | 10.1039/d2ob00440b |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1477-0520 |
| ispartof | Organic & biomolecular chemistry, 2022-05, Vol.20 (20), p.4167-4175 |
| issn | 1477-0520 1477-0539 |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Alkaloids Antineoplastic Agents Biological properties Carboxylic Acids Cycloaddition Cycloaddition Reaction Dienes Indoles Natural products Thiophenes |
| title | A facile protocol for the preparation of 2-carboxylated thieno [2,3- b ] indoles: a de novo access to alkaloid thienodolin |
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