Extracellular vesicles from blood of breast cancer women induce angiogenic processes in HUVECs
Breast cancer is the most frequent malignancy among women in developed countries and the main cause of death related to cancer in women worldwide. Extracellular vesicles (EVs) are vesicles with a variable size enclosed within a phospholipid bilayer that contain a variety of molecules with biological...
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| Veröffentlicht in: | Tissue & cell 2022-06, Vol.76, p.101814-101814, Article 101814 |
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| creator | Garcia-Hernandez, Alejandra Reyes-Uribe, Emmanuel Arce-Salinas, Claudia de la Cruz-Lopez, Karen-Griselda Manzo-Merino, Joaquin Guzman-Ortiz, Ana-Laura Quezada, Hector Cortes-Reynosa, Pedro Breton-Mora, Fernando Elizalde-Acosta, Irma Thompson-Bonilla, Rocio Salazar, Eduardo Perez |
| description | Breast cancer is the most frequent malignancy among women in developed countries and the main cause of death related to cancer in women worldwide. Extracellular vesicles (EVs) are vesicles with a variable size enclosed within a phospholipid bilayer that contain a variety of molecules with biological activity. Cancer cells release EVs that induce proliferation, escape from apoptosis, reprogramming energy metabolism, invasion and metastasis. In this study we studied whether EV fractions deprived of platelet EVs from breast cancer women (BC EVs) can mediate cell processes related with angiogenesis in human umbilical vein endothelial cells (HUVECs). Our findings demonstrate that BC EVs enhance migration, invasion and formation of new tubules in HUVECs, compared with EV fractions deprived of platelet EVs from healthy women (Ctrl EVs). In summary, we demonstrate, for the first time, that BC EVs induce cellular processes in HUVECs that participate in angiogenesis.
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•Extracellular vesicles from breast cancer women mediate angiogenesis.•Extracellular vesicles from breast cancer women mediate migration in HUVECs.•Extracellular vesicles from breast cancer women mediate invasion in HUVECs. |
| doi_str_mv | 10.1016/j.tice.2022.101814 |
| format | Article |
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•Extracellular vesicles from breast cancer women mediate angiogenesis.•Extracellular vesicles from breast cancer women mediate migration in HUVECs.•Extracellular vesicles from breast cancer women mediate invasion in HUVECs.</description><identifier>ISSN: 0040-8166</identifier><identifier>EISSN: 1532-3072</identifier><identifier>DOI: 10.1016/j.tice.2022.101814</identifier><identifier>PMID: 35526310</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Angiogenesis ; Apoptosis ; Biological activity ; Breast cancer ; Cell proliferation ; Developed countries ; Endothelial cells ; Energy metabolism ; Extracellular vesicles ; HUVECs ; Malignancy ; Metastases ; Phospholipids ; Platelets ; Tubules ; Umbilical vein ; Vesicles</subject><ispartof>Tissue & cell, 2022-06, Vol.76, p.101814-101814, Article 101814</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Jun 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-514c243a61a8e732038e85b2c1d47c038799801c2bd094da6009927b2afbd6ea3</citedby><cites>FETCH-LOGICAL-c384t-514c243a61a8e732038e85b2c1d47c038799801c2bd094da6009927b2afbd6ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0040816622000866$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35526310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia-Hernandez, Alejandra</creatorcontrib><creatorcontrib>Reyes-Uribe, Emmanuel</creatorcontrib><creatorcontrib>Arce-Salinas, Claudia</creatorcontrib><creatorcontrib>de la Cruz-Lopez, Karen-Griselda</creatorcontrib><creatorcontrib>Manzo-Merino, Joaquin</creatorcontrib><creatorcontrib>Guzman-Ortiz, Ana-Laura</creatorcontrib><creatorcontrib>Quezada, Hector</creatorcontrib><creatorcontrib>Cortes-Reynosa, Pedro</creatorcontrib><creatorcontrib>Breton-Mora, Fernando</creatorcontrib><creatorcontrib>Elizalde-Acosta, Irma</creatorcontrib><creatorcontrib>Thompson-Bonilla, Rocio</creatorcontrib><creatorcontrib>Salazar, Eduardo Perez</creatorcontrib><title>Extracellular vesicles from blood of breast cancer women induce angiogenic processes in HUVECs</title><title>Tissue & cell</title><addtitle>Tissue Cell</addtitle><description>Breast cancer is the most frequent malignancy among women in developed countries and the main cause of death related to cancer in women worldwide. Extracellular vesicles (EVs) are vesicles with a variable size enclosed within a phospholipid bilayer that contain a variety of molecules with biological activity. Cancer cells release EVs that induce proliferation, escape from apoptosis, reprogramming energy metabolism, invasion and metastasis. In this study we studied whether EV fractions deprived of platelet EVs from breast cancer women (BC EVs) can mediate cell processes related with angiogenesis in human umbilical vein endothelial cells (HUVECs). Our findings demonstrate that BC EVs enhance migration, invasion and formation of new tubules in HUVECs, compared with EV fractions deprived of platelet EVs from healthy women (Ctrl EVs). In summary, we demonstrate, for the first time, that BC EVs induce cellular processes in HUVECs that participate in angiogenesis.
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•Extracellular vesicles from breast cancer women mediate angiogenesis.•Extracellular vesicles from breast cancer women mediate migration in HUVECs.•Extracellular vesicles from breast cancer women mediate invasion in HUVECs.</description><subject>Angiogenesis</subject><subject>Apoptosis</subject><subject>Biological activity</subject><subject>Breast cancer</subject><subject>Cell proliferation</subject><subject>Developed countries</subject><subject>Endothelial cells</subject><subject>Energy metabolism</subject><subject>Extracellular vesicles</subject><subject>HUVECs</subject><subject>Malignancy</subject><subject>Metastases</subject><subject>Phospholipids</subject><subject>Platelets</subject><subject>Tubules</subject><subject>Umbilical vein</subject><subject>Vesicles</subject><issn>0040-8166</issn><issn>1532-3072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kE2LFDEQhoMo7rj6BzxIwIuXHisfnaTBiwyjKyx4cT0a0kn1kqG7sybdq_5708zqwYOnIsXzvlQeQl4y2DNg6u1pv0SPew6cbwvD5COyY63gjQDNH5MdgITGMKUuyLNSTgCgJdNPyYVoW64Egx35dvy5ZOdxHNfRZXqPJfoRCx1ymmg_phRoGmif0ZWFejd7zPRHmnCmcQ6rR-rm25hucY6e3uXksZSajjO9uvl6PJTn5MngxoIvHuYluflw_HK4aq4_f_x0eH_deGHk0rRMei6FU8wZ1IKDMGjannsWpPb1pbvOAPO8D9DJ4BRA13Hdczf0QaETl-TNubfe8H3Fstgplu1Xbsa0FsuVYtIwI3hFX_-DntKa53pdpYw2QrRMV4qfKZ9TKRkHe5fj5PIvy8Bu9u3JbvbtZt-e7dfQq4fqtZ8w_I380V2Bd2cAq4v7iNkWH7FKDTGjX2xI8X_9vwFvI5Rh</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Garcia-Hernandez, Alejandra</creator><creator>Reyes-Uribe, Emmanuel</creator><creator>Arce-Salinas, Claudia</creator><creator>de la Cruz-Lopez, Karen-Griselda</creator><creator>Manzo-Merino, Joaquin</creator><creator>Guzman-Ortiz, Ana-Laura</creator><creator>Quezada, Hector</creator><creator>Cortes-Reynosa, Pedro</creator><creator>Breton-Mora, Fernando</creator><creator>Elizalde-Acosta, Irma</creator><creator>Thompson-Bonilla, Rocio</creator><creator>Salazar, Eduardo Perez</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20220601</creationdate><title>Extracellular vesicles from blood of breast cancer women induce angiogenic processes in HUVECs</title><author>Garcia-Hernandez, Alejandra ; Reyes-Uribe, Emmanuel ; Arce-Salinas, Claudia ; de la Cruz-Lopez, Karen-Griselda ; Manzo-Merino, Joaquin ; Guzman-Ortiz, Ana-Laura ; Quezada, Hector ; Cortes-Reynosa, Pedro ; Breton-Mora, Fernando ; Elizalde-Acosta, Irma ; Thompson-Bonilla, Rocio ; Salazar, Eduardo Perez</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-514c243a61a8e732038e85b2c1d47c038799801c2bd094da6009927b2afbd6ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiogenesis</topic><topic>Apoptosis</topic><topic>Biological activity</topic><topic>Breast cancer</topic><topic>Cell proliferation</topic><topic>Developed countries</topic><topic>Endothelial cells</topic><topic>Energy metabolism</topic><topic>Extracellular vesicles</topic><topic>HUVECs</topic><topic>Malignancy</topic><topic>Metastases</topic><topic>Phospholipids</topic><topic>Platelets</topic><topic>Tubules</topic><topic>Umbilical vein</topic><topic>Vesicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Hernandez, Alejandra</creatorcontrib><creatorcontrib>Reyes-Uribe, Emmanuel</creatorcontrib><creatorcontrib>Arce-Salinas, Claudia</creatorcontrib><creatorcontrib>de la Cruz-Lopez, Karen-Griselda</creatorcontrib><creatorcontrib>Manzo-Merino, Joaquin</creatorcontrib><creatorcontrib>Guzman-Ortiz, Ana-Laura</creatorcontrib><creatorcontrib>Quezada, Hector</creatorcontrib><creatorcontrib>Cortes-Reynosa, Pedro</creatorcontrib><creatorcontrib>Breton-Mora, Fernando</creatorcontrib><creatorcontrib>Elizalde-Acosta, Irma</creatorcontrib><creatorcontrib>Thompson-Bonilla, Rocio</creatorcontrib><creatorcontrib>Salazar, Eduardo Perez</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Tissue & cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Hernandez, Alejandra</au><au>Reyes-Uribe, Emmanuel</au><au>Arce-Salinas, Claudia</au><au>de la Cruz-Lopez, Karen-Griselda</au><au>Manzo-Merino, Joaquin</au><au>Guzman-Ortiz, Ana-Laura</au><au>Quezada, Hector</au><au>Cortes-Reynosa, Pedro</au><au>Breton-Mora, Fernando</au><au>Elizalde-Acosta, Irma</au><au>Thompson-Bonilla, Rocio</au><au>Salazar, Eduardo Perez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extracellular vesicles from blood of breast cancer women induce angiogenic processes in HUVECs</atitle><jtitle>Tissue & cell</jtitle><addtitle>Tissue Cell</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>76</volume><spage>101814</spage><epage>101814</epage><pages>101814-101814</pages><artnum>101814</artnum><issn>0040-8166</issn><eissn>1532-3072</eissn><abstract>Breast cancer is the most frequent malignancy among women in developed countries and the main cause of death related to cancer in women worldwide. Extracellular vesicles (EVs) are vesicles with a variable size enclosed within a phospholipid bilayer that contain a variety of molecules with biological activity. Cancer cells release EVs that induce proliferation, escape from apoptosis, reprogramming energy metabolism, invasion and metastasis. In this study we studied whether EV fractions deprived of platelet EVs from breast cancer women (BC EVs) can mediate cell processes related with angiogenesis in human umbilical vein endothelial cells (HUVECs). Our findings demonstrate that BC EVs enhance migration, invasion and formation of new tubules in HUVECs, compared with EV fractions deprived of platelet EVs from healthy women (Ctrl EVs). In summary, we demonstrate, for the first time, that BC EVs induce cellular processes in HUVECs that participate in angiogenesis.
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•Extracellular vesicles from breast cancer women mediate angiogenesis.•Extracellular vesicles from breast cancer women mediate migration in HUVECs.•Extracellular vesicles from breast cancer women mediate invasion in HUVECs.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>35526310</pmid><doi>10.1016/j.tice.2022.101814</doi><tpages>1</tpages></addata></record> |
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| ispartof | Tissue & cell, 2022-06, Vol.76, p.101814-101814, Article 101814 |
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| source | Elsevier ScienceDirect Journals |
| subjects | Angiogenesis Apoptosis Biological activity Breast cancer Cell proliferation Developed countries Endothelial cells Energy metabolism Extracellular vesicles HUVECs Malignancy Metastases Phospholipids Platelets Tubules Umbilical vein Vesicles |
| title | Extracellular vesicles from blood of breast cancer women induce angiogenic processes in HUVECs |
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