PLAAT1 promotes p53 degradation via autophagy-lysosome pathway in zebrafish
PLAAT1 belongs to the PLAAT family and plays regulatory roles in cell growth, tumor suppression and phospholipid metabolism. However, whether PLAAT1 is involved in p53 mediated signaling has not been investigated. Here, we report that PLAAT1 promotes degradation of p53 in zebrafish. We found that th...
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| Veröffentlicht in: | Fish & shellfish immunology 2022-06, Vol.125, p.48-53 |
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| container_title | Fish & shellfish immunology |
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| creator | Zhao, Xin Huang, Wenji Guo, Jiahong Ji, Ning Feng, Jianhua Shi, Yanjie Chen, Kangyong Zou, Jun |
| description | PLAAT1 belongs to the PLAAT family and plays regulatory roles in cell growth, tumor suppression and phospholipid metabolism. However, whether PLAAT1 is involved in p53 mediated signaling has not been investigated. Here, we report that PLAAT1 promotes degradation of p53 in zebrafish. We found that the plaat1 gene was constitutively expressed in tissues including liver, kidney, spleen, intestine, eye and brain, with relative higher expression levels detected in the brain and eye. Overexpression of plaat1 led to inhibition of p53 and tnfα mRNA expression. Furthermore, it was shown that PLAAT1 interacted with p53 to facilitate p53 degradation via autophagy-lysosome dependent pathway. Our work indicates that PLAAT1 is involved in the interplay between p53 mediated cellular responses and autophagy.
•Plaat1 is constitutively expressed in tissues in zebrafish.•Overexpression of plaat1 inhibits p53 and tnfα expression.•PLAAT1 interacts with p53.•PLAAT1 promotes p53 degradation via autophagy-lysosome dependent pathway. |
| doi_str_mv | 10.1016/j.fsi.2022.05.001 |
| format | Article |
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•Plaat1 is constitutively expressed in tissues in zebrafish.•Overexpression of plaat1 inhibits p53 and tnfα expression.•PLAAT1 interacts with p53.•PLAAT1 promotes p53 degradation via autophagy-lysosome dependent pathway.</description><subject>Apoptosis</subject><subject>Autophagy</subject><subject>p53</subject><subject>Phospholipase A/acyltransferases</subject><subject>Protein interaction</subject><subject>Zebrafish</subject><issn>1050-4648</issn><issn>1095-9947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0E4lH4ADYoSzYJYzt2Y7GqEC9RCRawthxnQl01dbDTovL1uCqwZDVXozt3Zg4h5xQKClRezYs2uoIBYwWIAoDukWMKSuRKleP9rRaQl7KsjshJjHMAkFzCITniQjBZARyTp5fpZPJKsz74zg8Ys17wrMH3YBozOL_M1s5kZjX4fmbeN_liE330HWa9GWafZpO5ZfaFdTCti7NTctCaRcSznzoib3e3rzcP-fT5_vFmMs0tF3zIJW0Bx5LT0jKlkqis5XVtGDKDrFWCVwpNpRpbp24lKaXcKJneQBRUAh-Ry11uOvpjhXHQnYsWFwuzRL-KmklJy4qO07YRoTurDT7GgK3ug-tM2GgKestQz3ViqLcMNQidGKaZi5_4Vd1h8zfxCy0ZrncGTE-uHQYdrcOlxcYFtINuvPsn_hvoAID0</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Zhao, Xin</creator><creator>Huang, Wenji</creator><creator>Guo, Jiahong</creator><creator>Ji, Ning</creator><creator>Feng, Jianhua</creator><creator>Shi, Yanjie</creator><creator>Chen, Kangyong</creator><creator>Zou, Jun</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1440-9029</orcidid></search><sort><creationdate>20220601</creationdate><title>PLAAT1 promotes p53 degradation via autophagy-lysosome pathway in zebrafish</title><author>Zhao, Xin ; Huang, Wenji ; Guo, Jiahong ; Ji, Ning ; Feng, Jianhua ; Shi, Yanjie ; Chen, Kangyong ; Zou, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-61f0e76314c2997638cc3bba2e2ae2f95389ea89dcbbba861113a96648ee51603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Apoptosis</topic><topic>Autophagy</topic><topic>p53</topic><topic>Phospholipase A/acyltransferases</topic><topic>Protein interaction</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Xin</creatorcontrib><creatorcontrib>Huang, Wenji</creatorcontrib><creatorcontrib>Guo, Jiahong</creatorcontrib><creatorcontrib>Ji, Ning</creatorcontrib><creatorcontrib>Feng, Jianhua</creatorcontrib><creatorcontrib>Shi, Yanjie</creatorcontrib><creatorcontrib>Chen, Kangyong</creatorcontrib><creatorcontrib>Zou, Jun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fish & shellfish immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Xin</au><au>Huang, Wenji</au><au>Guo, Jiahong</au><au>Ji, Ning</au><au>Feng, Jianhua</au><au>Shi, Yanjie</au><au>Chen, Kangyong</au><au>Zou, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PLAAT1 promotes p53 degradation via autophagy-lysosome pathway in zebrafish</atitle><jtitle>Fish & shellfish immunology</jtitle><addtitle>Fish Shellfish Immunol</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>125</volume><spage>48</spage><epage>53</epage><pages>48-53</pages><issn>1050-4648</issn><eissn>1095-9947</eissn><abstract>PLAAT1 belongs to the PLAAT family and plays regulatory roles in cell growth, tumor suppression and phospholipid metabolism. However, whether PLAAT1 is involved in p53 mediated signaling has not been investigated. Here, we report that PLAAT1 promotes degradation of p53 in zebrafish. We found that the plaat1 gene was constitutively expressed in tissues including liver, kidney, spleen, intestine, eye and brain, with relative higher expression levels detected in the brain and eye. Overexpression of plaat1 led to inhibition of p53 and tnfα mRNA expression. Furthermore, it was shown that PLAAT1 interacted with p53 to facilitate p53 degradation via autophagy-lysosome dependent pathway. Our work indicates that PLAAT1 is involved in the interplay between p53 mediated cellular responses and autophagy.
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| source | Elsevier ScienceDirect Journals |
| subjects | Apoptosis Autophagy p53 Phospholipase A/acyltransferases Protein interaction Zebrafish |
| title | PLAAT1 promotes p53 degradation via autophagy-lysosome pathway in zebrafish |
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