Highly efficient catalytic production of oximes from ketones using in situ–generated H2O2

Peroxide as neededHydrogen peroxide for commercial applications is currently mass produced through an indirect process that involves reduction and reoxidation of a quinone. The trouble with making it straight from the elements is that concentrated mixtures of hydrogen and oxygen are dangerously expl...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2022-05, Vol.376 (6593), p.615-620
Hauptverfasser:	Lewis, Richard J, Ueura, Kenji, Liu, Xi, Fukuta, Yukimasa, Davies, Thomas E, Morgan, David J, Chen, Liwei, Qi, Jizhen, Singleton, James, Edwards, Jennifer K, Freakley, Simon J, Kiely, Christopher J, Yamamoto, Yasushi, Hutchings, Graham J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclohexanone Hydrogen peroxide Ketones Oximes Production methods Quinones Reoxidation
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Peroxide as neededHydrogen peroxide for commercial applications is currently mass produced through an indirect process that involves reduction and reoxidation of a quinone. The trouble with making it straight from the elements is that concentrated mixtures of hydrogen and oxygen are dangerously explosive. Lewis et al. report that direct peroxide synthesis at safe concentrations is compatible with a current industrial method for producing cyclohexanone oxime, a key precursor to nylon. The protocol could potentially offer substantial efficiency advantages for manufacturing a high-volume bulk chemical. —JSY
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.abl4822