Antitumor activity of pachymic acid in cervical cancer through inducing endoplasmic reticulum stress, mitochondrial dysfunction, and activating the AMPK pathway

Pachymic acid has various pharmacological effects, including anti‐inflammatory, antioxidant, immunomodulatory, and antitumor. However, the role of pachymic acid in cervical cancer remains unclear. So, we investigated the effects of pachymic acid in cervical cancer and elucidated the underlying mecha...

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Veröffentlicht in:	Environmental toxicology 2022-09, Vol.37 (9), p.2121-2132
Hauptverfasser:	Yang, Ting, Tian, Sijuan, Wang, Yaohui, Ji, Jing, Zhao, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids AMPK pathway Anticancer properties Antioxidants Antitumor activity Antitumour agents Apoptosis Apoptosis-inducing factor ATP Cancer Cervical cancer Cervix Cytochrome c Cytochromes Cytoplasm Depletion Endoplasmic reticulum Epithelial cells Epithelium ER stress Gene expression Immunomodulation Inflammation Membrane potential Mitochondria mitochondrial dysfunction Neoplasms pachymic acid Phosphorylation Reactive oxygen species Tauroursodeoxycholic acid Tumors Xenografts Xenotransplantation
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