Quantitative assessment of macular and circumpapillary retinal vessel density across all stages of Leber hereditary optic neuropathy using swept source optical coherence tomography angiography
Purpose To investigate the macular and circumpapillary retinal microvasculature across all stages of Leber hereditary optic neuropathy (LHON) using swept source optical coherence tomography angiography (OCTA). Methods This prospective, multicentre, cross‐sectional, observational study analysed a tot...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2022-12, Vol.100 (8), p.e1646-e1656 |
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| creator | Castillo, Lorena Berrozpe‐Villabona, Clara Miserachs‐García, Sergio Haulani, Hanan Gómez‐Gutiérrez, Cecilia Díaz‐García, Rosa S. González‐Martínez, Alba Fernández‐Sanz, Guillermo Morilla‐Grasa, Antonio García, Virginia Arias, Luis Caminal, José M. Casaroli‐Marano, Ricardo |
| description | Purpose
To investigate the macular and circumpapillary retinal microvasculature across all stages of Leber hereditary optic neuropathy (LHON) using swept source optical coherence tomography angiography (OCTA).
Methods
This prospective, multicentre, cross‐sectional, observational study analysed a total of 119 eyes of 60 patients with molecularly confirmed LHON across all stages and 120 eyes of 60 control subjects. Optical coherence tomography angiography maps centred on the fovea and optic disc were obtained to measure vessel densities (VDs) in the macular superficial (SCP) and deep (DCP) capillary plexuses, and the radial peripapillary capillary plexus (RPCP) respectively.
Results
In asymptomatic eyes, only the SCP showed significant changes on average (B coefficient = −0.72, 95% CI = −1.34 to −0.10, p = 0.022) or in sectors representing the papillomacular bundle (PMB) (B coefficient = −1.17, 95% CI = −2.23 to −0.11, p = 0.031). However, in chronic eyes, the greatest magnitude of change was found in the temporal sector of the RPCP (B coefficient = −12.36, 95% CI = −14.49 to −10.23, p |
| doi_str_mv | 10.1111/aos.15169 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2661086783</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2661086783</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2839-de7102b5dd70466f0ca662414881b87856a7b42d0bf2089469aa8a155bb03a873</originalsourceid><addsrcrecordid>eNp1kc9u1DAQxiMEoqVw4AWQJS5w2NZOYsc5VhX_pJUqBEjcookz2bpK7OCxW-3b8Wh4m6UHJHzxaPSbbzTfVxSvBT8X-V2Ap3MhhWqfFKeikXJTNUo_fazlz5PiBdEt50ooVT8vTiopy7pq5Wnx-2sCF22EaO-QARESzegi8yObwaQJAgM3MGODSfMCi51ya88CRutgYneZx4kN6MjGPQMTPBGDaWIUYYd00Nlij4HdYMAhL8rDfonWMIcp-AXizZ4lsm7H6B6XyMinYHBl8gLjD4Mud6Kf_S7AknlwO3usXxbPRpgIXx3_s-LHxw_frz5vttefvlxdbjem1FW7GbARvOzlMDS8VmrkBpQqa1FrLXrdaKmg6ety4P1Yct3WqgXQIKTse16Bbqqz4t2quwT_KyHFbrZkMLvh0CfqSqUE16rRVUbf_oPe5puyW5lqqrrlsuYqU-9X6sGygGO3BDtnezrBu0OsXY61e4g1s2-OiqmfcXgk_-aYgYsVuLcT7v-v1F1ef1sl_wBXdbGR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2734905406</pqid></control><display><type>article</type><title>Quantitative assessment of macular and circumpapillary retinal vessel density across all stages of Leber hereditary optic neuropathy using swept source optical coherence tomography angiography</title><source>Wiley Free Content</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Castillo, Lorena ; Berrozpe‐Villabona, Clara ; Miserachs‐García, Sergio ; Haulani, Hanan ; Gómez‐Gutiérrez, Cecilia ; Díaz‐García, Rosa S. ; González‐Martínez, Alba ; Fernández‐Sanz, Guillermo ; Morilla‐Grasa, Antonio ; García, Virginia ; Arias, Luis ; Caminal, José M. ; Casaroli‐Marano, Ricardo</creator><creatorcontrib>Castillo, Lorena ; Berrozpe‐Villabona, Clara ; Miserachs‐García, Sergio ; Haulani, Hanan ; Gómez‐Gutiérrez, Cecilia ; Díaz‐García, Rosa S. ; González‐Martínez, Alba ; Fernández‐Sanz, Guillermo ; Morilla‐Grasa, Antonio ; García, Virginia ; Arias, Luis ; Caminal, José M. ; Casaroli‐Marano, Ricardo</creatorcontrib><description>Purpose
To investigate the macular and circumpapillary retinal microvasculature across all stages of Leber hereditary optic neuropathy (LHON) using swept source optical coherence tomography angiography (OCTA).
Methods
This prospective, multicentre, cross‐sectional, observational study analysed a total of 119 eyes of 60 patients with molecularly confirmed LHON across all stages and 120 eyes of 60 control subjects. Optical coherence tomography angiography maps centred on the fovea and optic disc were obtained to measure vessel densities (VDs) in the macular superficial (SCP) and deep (DCP) capillary plexuses, and the radial peripapillary capillary plexus (RPCP) respectively.
Results
In asymptomatic eyes, only the SCP showed significant changes on average (B coefficient = −0.72, 95% CI = −1.34 to −0.10, p = 0.022) or in sectors representing the papillomacular bundle (PMB) (B coefficient = −1.17, 95% CI = −2.23 to −0.11, p = 0.031). However, in chronic eyes, the greatest magnitude of change was found in the temporal sector of the RPCP (B coefficient = −12.36, 95% CI = −14.49 to −10.23, p < 0.001). The RPCP showed the strongest correlations with visual acuity (VA, logarithm of the minimum angle of resolution; R = −0.677, p < 0.001) and structural parameters (R = 0.747, p < 0.001).
Conclusions
Retinal VD changes in the circumpapillary region of the PMB appear later than in the macula but end up being more profound and correlate better with VA and structural parameters. Further studies are needed to assess the clinical utility of retinal VDs as potential LHON biomarkers.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.15169</identifier><identifier>PMID: 35524395</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Acuity ; Angiography ; Blood vessels ; Eye ; Leber hereditary optic neuropathy ; Medical imaging ; Microvasculature ; Optic neuropathy ; optical coherence tomography angiography ; Optics ; Retina ; retinal plexuses ; retinal vessel density ; swept source ; Tomography</subject><ispartof>Acta ophthalmologica (Oxford, England), 2022-12, Vol.100 (8), p.e1646-e1656</ispartof><rights>2022 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2022 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2839-de7102b5dd70466f0ca662414881b87856a7b42d0bf2089469aa8a155bb03a873</citedby><cites>FETCH-LOGICAL-c2839-de7102b5dd70466f0ca662414881b87856a7b42d0bf2089469aa8a155bb03a873</cites><orcidid>0000-0003-0821-3636 ; 0000-0002-2513-8247 ; 0000-0003-0710-7831</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.15169$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.15169$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35524395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castillo, Lorena</creatorcontrib><creatorcontrib>Berrozpe‐Villabona, Clara</creatorcontrib><creatorcontrib>Miserachs‐García, Sergio</creatorcontrib><creatorcontrib>Haulani, Hanan</creatorcontrib><creatorcontrib>Gómez‐Gutiérrez, Cecilia</creatorcontrib><creatorcontrib>Díaz‐García, Rosa S.</creatorcontrib><creatorcontrib>González‐Martínez, Alba</creatorcontrib><creatorcontrib>Fernández‐Sanz, Guillermo</creatorcontrib><creatorcontrib>Morilla‐Grasa, Antonio</creatorcontrib><creatorcontrib>García, Virginia</creatorcontrib><creatorcontrib>Arias, Luis</creatorcontrib><creatorcontrib>Caminal, José M.</creatorcontrib><creatorcontrib>Casaroli‐Marano, Ricardo</creatorcontrib><title>Quantitative assessment of macular and circumpapillary retinal vessel density across all stages of Leber hereditary optic neuropathy using swept source optical coherence tomography angiography</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To investigate the macular and circumpapillary retinal microvasculature across all stages of Leber hereditary optic neuropathy (LHON) using swept source optical coherence tomography angiography (OCTA).
Methods
This prospective, multicentre, cross‐sectional, observational study analysed a total of 119 eyes of 60 patients with molecularly confirmed LHON across all stages and 120 eyes of 60 control subjects. Optical coherence tomography angiography maps centred on the fovea and optic disc were obtained to measure vessel densities (VDs) in the macular superficial (SCP) and deep (DCP) capillary plexuses, and the radial peripapillary capillary plexus (RPCP) respectively.
Results
In asymptomatic eyes, only the SCP showed significant changes on average (B coefficient = −0.72, 95% CI = −1.34 to −0.10, p = 0.022) or in sectors representing the papillomacular bundle (PMB) (B coefficient = −1.17, 95% CI = −2.23 to −0.11, p = 0.031). However, in chronic eyes, the greatest magnitude of change was found in the temporal sector of the RPCP (B coefficient = −12.36, 95% CI = −14.49 to −10.23, p < 0.001). The RPCP showed the strongest correlations with visual acuity (VA, logarithm of the minimum angle of resolution; R = −0.677, p < 0.001) and structural parameters (R = 0.747, p < 0.001).
Conclusions
Retinal VD changes in the circumpapillary region of the PMB appear later than in the macula but end up being more profound and correlate better with VA and structural parameters. Further studies are needed to assess the clinical utility of retinal VDs as potential LHON biomarkers.</description><subject>Acuity</subject><subject>Angiography</subject><subject>Blood vessels</subject><subject>Eye</subject><subject>Leber hereditary optic neuropathy</subject><subject>Medical imaging</subject><subject>Microvasculature</subject><subject>Optic neuropathy</subject><subject>optical coherence tomography angiography</subject><subject>Optics</subject><subject>Retina</subject><subject>retinal plexuses</subject><subject>retinal vessel density</subject><subject>swept source</subject><subject>Tomography</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kc9u1DAQxiMEoqVw4AWQJS5w2NZOYsc5VhX_pJUqBEjcookz2bpK7OCxW-3b8Wh4m6UHJHzxaPSbbzTfVxSvBT8X-V2Ap3MhhWqfFKeikXJTNUo_fazlz5PiBdEt50ooVT8vTiopy7pq5Wnx-2sCF22EaO-QARESzegi8yObwaQJAgM3MGODSfMCi51ya88CRutgYneZx4kN6MjGPQMTPBGDaWIUYYd00Nlij4HdYMAhL8rDfonWMIcp-AXizZ4lsm7H6B6XyMinYHBl8gLjD4Mud6Kf_S7AknlwO3usXxbPRpgIXx3_s-LHxw_frz5vttefvlxdbjem1FW7GbARvOzlMDS8VmrkBpQqa1FrLXrdaKmg6ety4P1Yct3WqgXQIKTse16Bbqqz4t2quwT_KyHFbrZkMLvh0CfqSqUE16rRVUbf_oPe5puyW5lqqrrlsuYqU-9X6sGygGO3BDtnezrBu0OsXY61e4g1s2-OiqmfcXgk_-aYgYsVuLcT7v-v1F1ef1sl_wBXdbGR</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Castillo, Lorena</creator><creator>Berrozpe‐Villabona, Clara</creator><creator>Miserachs‐García, Sergio</creator><creator>Haulani, Hanan</creator><creator>Gómez‐Gutiérrez, Cecilia</creator><creator>Díaz‐García, Rosa S.</creator><creator>González‐Martínez, Alba</creator><creator>Fernández‐Sanz, Guillermo</creator><creator>Morilla‐Grasa, Antonio</creator><creator>García, Virginia</creator><creator>Arias, Luis</creator><creator>Caminal, José M.</creator><creator>Casaroli‐Marano, Ricardo</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0821-3636</orcidid><orcidid>https://orcid.org/0000-0002-2513-8247</orcidid><orcidid>https://orcid.org/0000-0003-0710-7831</orcidid></search><sort><creationdate>202212</creationdate><title>Quantitative assessment of macular and circumpapillary retinal vessel density across all stages of Leber hereditary optic neuropathy using swept source optical coherence tomography angiography</title><author>Castillo, Lorena ; Berrozpe‐Villabona, Clara ; Miserachs‐García, Sergio ; Haulani, Hanan ; Gómez‐Gutiérrez, Cecilia ; Díaz‐García, Rosa S. ; González‐Martínez, Alba ; Fernández‐Sanz, Guillermo ; Morilla‐Grasa, Antonio ; García, Virginia ; Arias, Luis ; Caminal, José M. ; Casaroli‐Marano, Ricardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2839-de7102b5dd70466f0ca662414881b87856a7b42d0bf2089469aa8a155bb03a873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acuity</topic><topic>Angiography</topic><topic>Blood vessels</topic><topic>Eye</topic><topic>Leber hereditary optic neuropathy</topic><topic>Medical imaging</topic><topic>Microvasculature</topic><topic>Optic neuropathy</topic><topic>optical coherence tomography angiography</topic><topic>Optics</topic><topic>Retina</topic><topic>retinal plexuses</topic><topic>retinal vessel density</topic><topic>swept source</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castillo, Lorena</creatorcontrib><creatorcontrib>Berrozpe‐Villabona, Clara</creatorcontrib><creatorcontrib>Miserachs‐García, Sergio</creatorcontrib><creatorcontrib>Haulani, Hanan</creatorcontrib><creatorcontrib>Gómez‐Gutiérrez, Cecilia</creatorcontrib><creatorcontrib>Díaz‐García, Rosa S.</creatorcontrib><creatorcontrib>González‐Martínez, Alba</creatorcontrib><creatorcontrib>Fernández‐Sanz, Guillermo</creatorcontrib><creatorcontrib>Morilla‐Grasa, Antonio</creatorcontrib><creatorcontrib>García, Virginia</creatorcontrib><creatorcontrib>Arias, Luis</creatorcontrib><creatorcontrib>Caminal, José M.</creatorcontrib><creatorcontrib>Casaroli‐Marano, Ricardo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castillo, Lorena</au><au>Berrozpe‐Villabona, Clara</au><au>Miserachs‐García, Sergio</au><au>Haulani, Hanan</au><au>Gómez‐Gutiérrez, Cecilia</au><au>Díaz‐García, Rosa S.</au><au>González‐Martínez, Alba</au><au>Fernández‐Sanz, Guillermo</au><au>Morilla‐Grasa, Antonio</au><au>García, Virginia</au><au>Arias, Luis</au><au>Caminal, José M.</au><au>Casaroli‐Marano, Ricardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative assessment of macular and circumpapillary retinal vessel density across all stages of Leber hereditary optic neuropathy using swept source optical coherence tomography angiography</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2022-12</date><risdate>2022</risdate><volume>100</volume><issue>8</issue><spage>e1646</spage><epage>e1656</epage><pages>e1646-e1656</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
To investigate the macular and circumpapillary retinal microvasculature across all stages of Leber hereditary optic neuropathy (LHON) using swept source optical coherence tomography angiography (OCTA).
Methods
This prospective, multicentre, cross‐sectional, observational study analysed a total of 119 eyes of 60 patients with molecularly confirmed LHON across all stages and 120 eyes of 60 control subjects. Optical coherence tomography angiography maps centred on the fovea and optic disc were obtained to measure vessel densities (VDs) in the macular superficial (SCP) and deep (DCP) capillary plexuses, and the radial peripapillary capillary plexus (RPCP) respectively.
Results
In asymptomatic eyes, only the SCP showed significant changes on average (B coefficient = −0.72, 95% CI = −1.34 to −0.10, p = 0.022) or in sectors representing the papillomacular bundle (PMB) (B coefficient = −1.17, 95% CI = −2.23 to −0.11, p = 0.031). However, in chronic eyes, the greatest magnitude of change was found in the temporal sector of the RPCP (B coefficient = −12.36, 95% CI = −14.49 to −10.23, p < 0.001). The RPCP showed the strongest correlations with visual acuity (VA, logarithm of the minimum angle of resolution; R = −0.677, p < 0.001) and structural parameters (R = 0.747, p < 0.001).
Conclusions
Retinal VD changes in the circumpapillary region of the PMB appear later than in the macula but end up being more profound and correlate better with VA and structural parameters. Further studies are needed to assess the clinical utility of retinal VDs as potential LHON biomarkers.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35524395</pmid><doi>10.1111/aos.15169</doi><tpages>1656</tpages><orcidid>https://orcid.org/0000-0003-0821-3636</orcidid><orcidid>https://orcid.org/0000-0002-2513-8247</orcidid><orcidid>https://orcid.org/0000-0003-0710-7831</orcidid></addata></record> |
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| source | Wiley Free Content; Wiley Online Library Journals Frontfile Complete |
| subjects | Acuity Angiography Blood vessels Eye Leber hereditary optic neuropathy Medical imaging Microvasculature Optic neuropathy optical coherence tomography angiography Optics Retina retinal plexuses retinal vessel density swept source Tomography |
| title | Quantitative assessment of macular and circumpapillary retinal vessel density across all stages of Leber hereditary optic neuropathy using swept source optical coherence tomography angiography |
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