Ferulic acid ameliorates acetaminophen‐induced acute liver injury by promoting AMPK‐mediated protective autophagy

Acetaminophen (APAP), one of the most widely used antipyretics and analgesics, principally results in acute liver injury (ALI) in developed countries when taken overdose. Ferulic acid (FA) is a natural polyphenol compound existing in many plants that has free radical scavenging, anti‐inflammatory, a...

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Veröffentlicht in:	IUBMB life 2022-09, Vol.74 (9), p.880-895
Hauptverfasser:	Wu, Jianzhi, Zhou, Fei, Fan, Guifang, Liu, Jia, Wang, Yao, Xue, Xiaoyong, Lyu, Xiangjun, Lin, Sheng, Li, Xiaojiaoyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen AMPK Analgesics Apoptosis Autophagy Caspase-3 Ferulic acid hepatocyte Hepatocyte nuclear factor 4 Hepatocytes Inflammation Liver Membrane potential Mitochondria Overdose Oxidants Oxidative stress Phosphorylation Serum levels
Online-Zugang:	Volltext
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