Evolving the surveillance and workup of heart transplant rejection: A real‐world analysis of the Molecular Microscope Diagnostic System

The Molecular Microscope Diagnostic System (MMDx) analyzes RNA transcripts of transplanted heart tissue to differentiate among T cell–mediated rejection (TCMR), antibody‐mediated rejection (AMR), injury, and healthy tissue. However, little is known about its performance in relation to other modaliti...

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Veröffentlicht in:	American journal of transplantation 2022-10, Vol.22 (10), p.2443-2450
Hauptverfasser:	Alam, Amit, Van Zyl, Johanna, Paul Milligan, Gregory, Michelle McKean, Staci, Patel, Raksha, Anne Hall, Shelley
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Agreements Antibodies Biopsy Cell differentiation Cell-Free Nucleic Acids - genetics clinical research/practice Doxorubicin - analogs & derivatives Graft rejection Graft Rejection - diagnosis Graft Rejection - etiology Heart Diseases Heart transplantation Heart Transplantation - adverse effects heart transplantation/cardiology Heart transplants Humans Kidney Transplantation Lymphocytes T Medical diagnosis microarray/gene array molecular biology: mRNA/mRNA expression Postoperative Complications rejection rejection: antibody‐mediated (ABMR) rejection: T cell mediated (TCMR) Retrospective Studies RNA Surveillance
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