FDG PET/CT in differentiated thyroid cancer patients with low thyroglobulin levels
Objective To evaluate the usefulness of [18F]fluorodeoxyglucose (FDG) positron emissive tomography (PET)/CT in patients with low detectable thyroglobulin levels suspicious for persistent or recurrent differentiated thyroid cancer (DTC). Methods A retrospective case series study evaluating FDG PET/CT...
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| Veröffentlicht in: | European journal of endocrinology 2022-07, Vol.187 (1), p.101-110 |
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| creator | Lebbink, Chantal A de Vries, Lisa H Borel Rinkes, Inne H M Braat, Arthur J A T van Leeuwaarde, Rachel S Lodewijk, Lutske van Treijen, Mark J C Vriens, Menno R Valk, Gerlof D van Santen, Hanneke M de Keizer, Bart |
| description | Objective To evaluate the usefulness of [18F]fluorodeoxyglucose (FDG) positron emissive tomography (PET)/CT in patients with low detectable thyroglobulin levels suspicious for persistent or recurrent differentiated thyroid cancer (DTC). Methods A retrospective case series study evaluating FDG PET/CT in patients with detectable thyroglobulin (Tg) levels (≥0.20 and |
| doi_str_mv | 10.1530/EJE-22-0072 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2661083600</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2661083600</sourcerecordid><originalsourceid>FETCH-LOGICAL-b289t-dd5efc9a313885897022f39c4ccbd3555ab25efbecf56a5d4ddc4804b2c7dfd83</originalsourceid><addsrcrecordid>eNp90M1LwzAYBvAgipsfJ-9S8CJIXT6aNj3K7KYyUGSCt5Lmw2V0zUxax_57UzY9ePCUQH55eN8HgAsEbxElcFQ8FTHGMYQZPgBDlGR5nDLyfgiGkMEkTtKEDMCJ90sIUbjDYzAglGKUITgEr5P7afRSzEfjeWSaSBqtlVNNa3irZNQuts4aGQneCOWiNW9NePPRxrSLqLabHfiobdXV4XetvlTtz8CR5rVX5_vzFLxNivn4IZ49Tx_Hd7O4wixvYymp0iLnBBHGKMsziLEmuUiEqGQYkPIKB1EpoWnKqUykFElYqMIik1oycgqud7lrZz875dtyZbxQdc0bZTtf4jRFkJEUwkCv_tCl7VwTpgsqyxlFLO0Db3ZKOOu9U7pcO7PiblsiWPZVl6HqEuOyrzroy31mV62U_LU_3QaAdqAy1ou-OKON4P-GfgOEH4kI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2679851868</pqid></control><display><type>article</type><title>FDG PET/CT in differentiated thyroid cancer patients with low thyroglobulin levels</title><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Lebbink, Chantal A ; de Vries, Lisa H ; Borel Rinkes, Inne H M ; Braat, Arthur J A T ; van Leeuwaarde, Rachel S ; Lodewijk, Lutske ; van Treijen, Mark J C ; Vriens, Menno R ; Valk, Gerlof D ; van Santen, Hanneke M ; de Keizer, Bart</creator><creatorcontrib>Lebbink, Chantal A ; de Vries, Lisa H ; Borel Rinkes, Inne H M ; Braat, Arthur J A T ; van Leeuwaarde, Rachel S ; Lodewijk, Lutske ; van Treijen, Mark J C ; Vriens, Menno R ; Valk, Gerlof D ; van Santen, Hanneke M ; de Keizer, Bart</creatorcontrib><description>Objective To evaluate the usefulness of [18F]fluorodeoxyglucose (FDG) positron emissive tomography (PET)/CT in patients with low detectable thyroglobulin levels suspicious for persistent or recurrent differentiated thyroid cancer (DTC). Methods A retrospective case series study evaluating FDG PET/CT in patients with detectable thyroglobulin (Tg) levels (≥0.20 and <10.00 ng/mL) after initial treatment with total thyroidectomy and I-131 thyroid remnant ablation for pT1-3aN0-1bM0 DTC. Sensitivity, specificity, positive (PPV) and negative predictive value (NPV) of FDG PET/CT were calculated. Results Twenty-seven patients underwent FDG PET/CT. Median Tg level at FDG PET/CT was 2.00 ng/mL (range 0.30–9.00). FDG PET/CT was positive in 14 patients (51.9%): lesions suspicious for lymph node metastases were depicted in 12 patients, and lung metastases in 2. DTC was confirmed in 13/14 FDG PET/CT-positive patients. In 9/13 patients with a negative FDG PET/CT, DTC was confirmed ≤3 months after FDG PET/CT. The sensitivity, PPV, specificity and NPV were 59.1, 92.9, 80.0 and 30.8%, respectively. Conclusions This case series shows that FDG PET/CT might be useful to detect persistent or recurrent DTC in patients with low detectable Tg. However, when FDG PET/CT is negative, this does not rule out DTC and further investigations are necessary.</description><identifier>ISSN: 0804-4643</identifier><identifier>EISSN: 1479-683X</identifier><identifier>DOI: 10.1530/EJE-22-0072</identifier><identifier>PMID: 35521710</identifier><language>eng</language><publisher>England: Bioscientifica Ltd</publisher><subject>Lymph nodes ; Metastases ; Metastasis ; Original ; Patients ; Positron emission tomography ; Thyroglobulin ; Thyroid cancer ; Thyroidectomy</subject><ispartof>European journal of endocrinology, 2022-07, Vol.187 (1), p.101-110</ispartof><rights>European Society of Endocrinology</rights><rights>Copyright BioScientifica Ltd. Jul 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b289t-dd5efc9a313885897022f39c4ccbd3555ab25efbecf56a5d4ddc4804b2c7dfd83</citedby><cites>FETCH-LOGICAL-b289t-dd5efc9a313885897022f39c4ccbd3555ab25efbecf56a5d4ddc4804b2c7dfd83</cites><orcidid>0000-0002-9897-334X ; 0000-0003-3853-297X ; 0000-0002-6270-9483</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35521710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lebbink, Chantal A</creatorcontrib><creatorcontrib>de Vries, Lisa H</creatorcontrib><creatorcontrib>Borel Rinkes, Inne H M</creatorcontrib><creatorcontrib>Braat, Arthur J A T</creatorcontrib><creatorcontrib>van Leeuwaarde, Rachel S</creatorcontrib><creatorcontrib>Lodewijk, Lutske</creatorcontrib><creatorcontrib>van Treijen, Mark J C</creatorcontrib><creatorcontrib>Vriens, Menno R</creatorcontrib><creatorcontrib>Valk, Gerlof D</creatorcontrib><creatorcontrib>van Santen, Hanneke M</creatorcontrib><creatorcontrib>de Keizer, Bart</creatorcontrib><title>FDG PET/CT in differentiated thyroid cancer patients with low thyroglobulin levels</title><title>European journal of endocrinology</title><addtitle>Eur J Endocrinol</addtitle><description>Objective To evaluate the usefulness of [18F]fluorodeoxyglucose (FDG) positron emissive tomography (PET)/CT in patients with low detectable thyroglobulin levels suspicious for persistent or recurrent differentiated thyroid cancer (DTC). Methods A retrospective case series study evaluating FDG PET/CT in patients with detectable thyroglobulin (Tg) levels (≥0.20 and <10.00 ng/mL) after initial treatment with total thyroidectomy and I-131 thyroid remnant ablation for pT1-3aN0-1bM0 DTC. Sensitivity, specificity, positive (PPV) and negative predictive value (NPV) of FDG PET/CT were calculated. Results Twenty-seven patients underwent FDG PET/CT. Median Tg level at FDG PET/CT was 2.00 ng/mL (range 0.30–9.00). FDG PET/CT was positive in 14 patients (51.9%): lesions suspicious for lymph node metastases were depicted in 12 patients, and lung metastases in 2. DTC was confirmed in 13/14 FDG PET/CT-positive patients. In 9/13 patients with a negative FDG PET/CT, DTC was confirmed ≤3 months after FDG PET/CT. The sensitivity, PPV, specificity and NPV were 59.1, 92.9, 80.0 and 30.8%, respectively. Conclusions This case series shows that FDG PET/CT might be useful to detect persistent or recurrent DTC in patients with low detectable Tg. However, when FDG PET/CT is negative, this does not rule out DTC and further investigations are necessary.</description><subject>Lymph nodes</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Original</subject><subject>Patients</subject><subject>Positron emission tomography</subject><subject>Thyroglobulin</subject><subject>Thyroid cancer</subject><subject>Thyroidectomy</subject><issn>0804-4643</issn><issn>1479-683X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp90M1LwzAYBvAgipsfJ-9S8CJIXT6aNj3K7KYyUGSCt5Lmw2V0zUxax_57UzY9ePCUQH55eN8HgAsEbxElcFQ8FTHGMYQZPgBDlGR5nDLyfgiGkMEkTtKEDMCJ90sIUbjDYzAglGKUITgEr5P7afRSzEfjeWSaSBqtlVNNa3irZNQuts4aGQneCOWiNW9NePPRxrSLqLabHfiobdXV4XetvlTtz8CR5rVX5_vzFLxNivn4IZ49Tx_Hd7O4wixvYymp0iLnBBHGKMsziLEmuUiEqGQYkPIKB1EpoWnKqUykFElYqMIik1oycgqud7lrZz875dtyZbxQdc0bZTtf4jRFkJEUwkCv_tCl7VwTpgsqyxlFLO0Db3ZKOOu9U7pcO7PiblsiWPZVl6HqEuOyrzroy31mV62U_LU_3QaAdqAy1ou-OKON4P-GfgOEH4kI</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Lebbink, Chantal A</creator><creator>de Vries, Lisa H</creator><creator>Borel Rinkes, Inne H M</creator><creator>Braat, Arthur J A T</creator><creator>van Leeuwaarde, Rachel S</creator><creator>Lodewijk, Lutske</creator><creator>van Treijen, Mark J C</creator><creator>Vriens, Menno R</creator><creator>Valk, Gerlof D</creator><creator>van Santen, Hanneke M</creator><creator>de Keizer, Bart</creator><general>Bioscientifica Ltd</general><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9897-334X</orcidid><orcidid>https://orcid.org/0000-0003-3853-297X</orcidid><orcidid>https://orcid.org/0000-0002-6270-9483</orcidid></search><sort><creationdate>20220701</creationdate><title>FDG PET/CT in differentiated thyroid cancer patients with low thyroglobulin levels</title><author>Lebbink, Chantal A ; de Vries, Lisa H ; Borel Rinkes, Inne H M ; Braat, Arthur J A T ; van Leeuwaarde, Rachel S ; Lodewijk, Lutske ; van Treijen, Mark J C ; Vriens, Menno R ; Valk, Gerlof D ; van Santen, Hanneke M ; de Keizer, Bart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b289t-dd5efc9a313885897022f39c4ccbd3555ab25efbecf56a5d4ddc4804b2c7dfd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Lymph nodes</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Original</topic><topic>Patients</topic><topic>Positron emission tomography</topic><topic>Thyroglobulin</topic><topic>Thyroid cancer</topic><topic>Thyroidectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lebbink, Chantal A</creatorcontrib><creatorcontrib>de Vries, Lisa H</creatorcontrib><creatorcontrib>Borel Rinkes, Inne H M</creatorcontrib><creatorcontrib>Braat, Arthur J A T</creatorcontrib><creatorcontrib>van Leeuwaarde, Rachel S</creatorcontrib><creatorcontrib>Lodewijk, Lutske</creatorcontrib><creatorcontrib>van Treijen, Mark J C</creatorcontrib><creatorcontrib>Vriens, Menno R</creatorcontrib><creatorcontrib>Valk, Gerlof D</creatorcontrib><creatorcontrib>van Santen, Hanneke M</creatorcontrib><creatorcontrib>de Keizer, Bart</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lebbink, Chantal A</au><au>de Vries, Lisa H</au><au>Borel Rinkes, Inne H M</au><au>Braat, Arthur J A T</au><au>van Leeuwaarde, Rachel S</au><au>Lodewijk, Lutske</au><au>van Treijen, Mark J C</au><au>Vriens, Menno R</au><au>Valk, Gerlof D</au><au>van Santen, Hanneke M</au><au>de Keizer, Bart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FDG PET/CT in differentiated thyroid cancer patients with low thyroglobulin levels</atitle><jtitle>European journal of endocrinology</jtitle><addtitle>Eur J Endocrinol</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>187</volume><issue>1</issue><spage>101</spage><epage>110</epage><pages>101-110</pages><issn>0804-4643</issn><eissn>1479-683X</eissn><abstract>Objective To evaluate the usefulness of [18F]fluorodeoxyglucose (FDG) positron emissive tomography (PET)/CT in patients with low detectable thyroglobulin levels suspicious for persistent or recurrent differentiated thyroid cancer (DTC). Methods A retrospective case series study evaluating FDG PET/CT in patients with detectable thyroglobulin (Tg) levels (≥0.20 and <10.00 ng/mL) after initial treatment with total thyroidectomy and I-131 thyroid remnant ablation for pT1-3aN0-1bM0 DTC. Sensitivity, specificity, positive (PPV) and negative predictive value (NPV) of FDG PET/CT were calculated. Results Twenty-seven patients underwent FDG PET/CT. Median Tg level at FDG PET/CT was 2.00 ng/mL (range 0.30–9.00). FDG PET/CT was positive in 14 patients (51.9%): lesions suspicious for lymph node metastases were depicted in 12 patients, and lung metastases in 2. DTC was confirmed in 13/14 FDG PET/CT-positive patients. In 9/13 patients with a negative FDG PET/CT, DTC was confirmed ≤3 months after FDG PET/CT. The sensitivity, PPV, specificity and NPV were 59.1, 92.9, 80.0 and 30.8%, respectively. Conclusions This case series shows that FDG PET/CT might be useful to detect persistent or recurrent DTC in patients with low detectable Tg. However, when FDG PET/CT is negative, this does not rule out DTC and further investigations are necessary.</abstract><cop>England</cop><pub>Bioscientifica Ltd</pub><pmid>35521710</pmid><doi>10.1530/EJE-22-0072</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9897-334X</orcidid><orcidid>https://orcid.org/0000-0003-3853-297X</orcidid><orcidid>https://orcid.org/0000-0002-6270-9483</orcidid></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| subjects | Lymph nodes Metastases Metastasis Original Patients Positron emission tomography Thyroglobulin Thyroid cancer Thyroidectomy |
| title | FDG PET/CT in differentiated thyroid cancer patients with low thyroglobulin levels |
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