Association between HER2 heterogeneity and clinical outcomes of HER2-positive gastric cancer patients treated with trastuzumab

Background The GASTHER1 study showed that re-evaluation of HER2 status rescued 8% of HER2-positive gastric cancer (GC) patients with initially HER2-negative GC. Since rescued HER2 positivity represents HER2 heterogeneity, we aimed to investigate this in a larger cohort with longer follow-up duration...

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Veröffentlicht in:	Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2022-07, Vol.25 (4), p.794-803
Hauptverfasser:	Bang, Kyunghye, Cheon, Jaekyung, Park, Young Soo, Kim, Hyung-Don, Ryu, Min-Hee, Park, Yangsoon, Moon, Meesun, Lee, Hyungeun, Kang, Yoon-Koo
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Biopsy Cancer Research Chemotherapy Clinical outcomes ErbB-2 protein Gastric cancer Gastroenterology Hybridization Immunohistochemistry Medicine Medicine & Public Health Monoclonal antibodies Oncology Original Article Patients Surgical Oncology Survival Targeted cancer therapy Trastuzumab
Online-Zugang:	Volltext
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