Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications
Smart hydrogels comprising carboxymethyl guar gum and chitosan (CMGG/CS) have been fabricated using tetraethyl orthosilicate as the crosslinker. To render the hydrogels an improved biological efficacy, non-thermal plasma assisted surface modification have been performed using Ar, O 2 and a mixture o...
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| Veröffentlicht in: | RSC advances 2019-01, Vol.9 (3), p.175-1716 |
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| creator | Dalei, Ganeswar Das, Subhraseema Das, Smruti Prava |
| description | Smart hydrogels comprising carboxymethyl guar gum and chitosan (CMGG/CS) have been fabricated using tetraethyl orthosilicate as the crosslinker. To render the hydrogels an improved biological efficacy, non-thermal plasma assisted surface modification have been performed using Ar, O
2
and a mixture of Ar and O
2
gases. Enhanced surface wettability was witnessed post-plasma treatment. AFM analyses revealed the topographical changes of the hydrogels at the nano-scale level without any adverse effect on their bulk physical structure. The hydrogels exhibited pH-responsive swelling with maximum swelling in neutral pH. The release of diclofenac sodium from the hydrogels confirmed their potential towards colon-targeted drug delivery. Excellent biofilm eradication features against
E. coli
was demonstrated by the hydrogels. Hemolytic assay on human RBCs affirmed their hemocompatibility. Moreover, the hydrogels were found to be remarkably biodegradable. Thus, non-thermal plasma assisted surface nano-textured CMGG/CS hydrogels can be efficaciously explored for their diverse applications in biomedicine.
Surface nano-textured carboxymethyl guar gum/chitosan smart hydrogels by non-thermal plasma for biomedical applications. |
| doi_str_mv | 10.1039/c8ra09161g |
| format | Article |
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2
and a mixture of Ar and O
2
gases. Enhanced surface wettability was witnessed post-plasma treatment. AFM analyses revealed the topographical changes of the hydrogels at the nano-scale level without any adverse effect on their bulk physical structure. The hydrogels exhibited pH-responsive swelling with maximum swelling in neutral pH. The release of diclofenac sodium from the hydrogels confirmed their potential towards colon-targeted drug delivery. Excellent biofilm eradication features against
E. coli
was demonstrated by the hydrogels. Hemolytic assay on human RBCs affirmed their hemocompatibility. Moreover, the hydrogels were found to be remarkably biodegradable. Thus, non-thermal plasma assisted surface nano-textured CMGG/CS hydrogels can be efficaciously explored for their diverse applications in biomedicine.
Surface nano-textured carboxymethyl guar gum/chitosan smart hydrogels by non-thermal plasma for biomedical applications.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/c8ra09161g</identifier><identifier>PMID: 35518016</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Biodegradability ; Biomedical materials ; Chemistry ; Chitosan ; Colon ; Crosslinking ; Diclofenac ; Drug delivery systems ; E coli ; Guar gum ; Hydrogels ; Plasma ; Swelling ; Tetraethyl orthosilicate ; Thermal plasmas ; Wettability</subject><ispartof>RSC advances, 2019-01, Vol.9 (3), p.175-1716</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2019</rights><rights>This journal is © The Royal Society of Chemistry 2019 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-cd008a57fcf76999e3d127e678a034473b578d2257d0d6e3d5f642b394f39e2a3</citedby><cites>FETCH-LOGICAL-c428t-cd008a57fcf76999e3d127e678a034473b578d2257d0d6e3d5f642b394f39e2a3</cites><orcidid>0000-0002-8244-8719</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059754/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059754/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35518016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dalei, Ganeswar</creatorcontrib><creatorcontrib>Das, Subhraseema</creatorcontrib><creatorcontrib>Das, Smruti Prava</creatorcontrib><title>Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Smart hydrogels comprising carboxymethyl guar gum and chitosan (CMGG/CS) have been fabricated using tetraethyl orthosilicate as the crosslinker. To render the hydrogels an improved biological efficacy, non-thermal plasma assisted surface modification have been performed using Ar, O
2
and a mixture of Ar and O
2
gases. Enhanced surface wettability was witnessed post-plasma treatment. AFM analyses revealed the topographical changes of the hydrogels at the nano-scale level without any adverse effect on their bulk physical structure. The hydrogels exhibited pH-responsive swelling with maximum swelling in neutral pH. The release of diclofenac sodium from the hydrogels confirmed their potential towards colon-targeted drug delivery. Excellent biofilm eradication features against
E. coli
was demonstrated by the hydrogels. Hemolytic assay on human RBCs affirmed their hemocompatibility. Moreover, the hydrogels were found to be remarkably biodegradable. Thus, non-thermal plasma assisted surface nano-textured CMGG/CS hydrogels can be efficaciously explored for their diverse applications in biomedicine.
Surface nano-textured carboxymethyl guar gum/chitosan smart hydrogels by non-thermal plasma for biomedical applications.</description><subject>Biodegradability</subject><subject>Biomedical materials</subject><subject>Chemistry</subject><subject>Chitosan</subject><subject>Colon</subject><subject>Crosslinking</subject><subject>Diclofenac</subject><subject>Drug delivery systems</subject><subject>E coli</subject><subject>Guar gum</subject><subject>Hydrogels</subject><subject>Plasma</subject><subject>Swelling</subject><subject>Tetraethyl orthosilicate</subject><subject>Thermal plasmas</subject><subject>Wettability</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkt9r1TAcxYM43Jh78V0p-CJCXZI2v16EcdEpjA2GPodv0_S2I01qkuruf2_0zus0D8mXnA-HE04QekHwO4IbdW5kBKwIJ9sn6ITiltcUc_X00XyMzlK6w2VxRignz9BxwxiRmPAT9OM6-DqPNs7gqsVBmqGClKaUbV-lNQ5gbOXBhzrb-7zGcmsgduF-N9s87ly1XSGWbT4345RDAl-Nuz6GrXWpGkKsuinMtp9MsYdlcWXIU_DpOToawCV79nCeoq8fP3zZfKqvbi4_by6uatNSmWvTYyyBicEMgiulbNMTKiwXEnDTtqLpmJA9pUz0uOdFZQNvadeodmiUpdCcovd732XtSg5jfY7g9BKnGeJOB5j0v4qfRr0N37XCTAnWFoM3DwYxfFttynqekrHOgbdhTZpyTrCkLSEFff0fehfW6MvzNCVc0FYwKQr1dk-ZGFKKdjiEIVj_qlRv5O3F70ovC_zqcfwD-qfAArzcAzGZg_r3TzQ_ATnyqJw</recordid><startdate>20190114</startdate><enddate>20190114</enddate><creator>Dalei, Ganeswar</creator><creator>Das, Subhraseema</creator><creator>Das, Smruti Prava</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8244-8719</orcidid></search><sort><creationdate>20190114</creationdate><title>Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications</title><author>Dalei, Ganeswar ; Das, Subhraseema ; Das, Smruti Prava</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-cd008a57fcf76999e3d127e678a034473b578d2257d0d6e3d5f642b394f39e2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biodegradability</topic><topic>Biomedical materials</topic><topic>Chemistry</topic><topic>Chitosan</topic><topic>Colon</topic><topic>Crosslinking</topic><topic>Diclofenac</topic><topic>Drug delivery systems</topic><topic>E coli</topic><topic>Guar gum</topic><topic>Hydrogels</topic><topic>Plasma</topic><topic>Swelling</topic><topic>Tetraethyl orthosilicate</topic><topic>Thermal plasmas</topic><topic>Wettability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dalei, Ganeswar</creatorcontrib><creatorcontrib>Das, Subhraseema</creatorcontrib><creatorcontrib>Das, Smruti Prava</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dalei, Ganeswar</au><au>Das, Subhraseema</au><au>Das, Smruti Prava</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2019-01-14</date><risdate>2019</risdate><volume>9</volume><issue>3</issue><spage>175</spage><epage>1716</epage><pages>175-1716</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Smart hydrogels comprising carboxymethyl guar gum and chitosan (CMGG/CS) have been fabricated using tetraethyl orthosilicate as the crosslinker. To render the hydrogels an improved biological efficacy, non-thermal plasma assisted surface modification have been performed using Ar, O
2
and a mixture of Ar and O
2
gases. Enhanced surface wettability was witnessed post-plasma treatment. AFM analyses revealed the topographical changes of the hydrogels at the nano-scale level without any adverse effect on their bulk physical structure. The hydrogels exhibited pH-responsive swelling with maximum swelling in neutral pH. The release of diclofenac sodium from the hydrogels confirmed their potential towards colon-targeted drug delivery. Excellent biofilm eradication features against
E. coli
was demonstrated by the hydrogels. Hemolytic assay on human RBCs affirmed their hemocompatibility. Moreover, the hydrogels were found to be remarkably biodegradable. Thus, non-thermal plasma assisted surface nano-textured CMGG/CS hydrogels can be efficaciously explored for their diverse applications in biomedicine.
Surface nano-textured carboxymethyl guar gum/chitosan smart hydrogels by non-thermal plasma for biomedical applications.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35518016</pmid><doi>10.1039/c8ra09161g</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-8244-8719</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Biodegradability Biomedical materials Chemistry Chitosan Colon Crosslinking Diclofenac Drug delivery systems E coli Guar gum Hydrogels Plasma Swelling Tetraethyl orthosilicate Thermal plasmas Wettability |
| title | Non-thermal plasma assisted surface nano-textured carboxymethyl guar gum/chitosan hydrogels for biomedical applications |
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