Enhanced water permeability across a physiological droplet interface bilayer doped with fullerenes
We measure the water permeability across a physiological lipid bilayer produced by the droplet interface bilayer (DiB) technique. This lipid bilayer can be considered as physiologically relevant because it presents a lipidic composition close to human cell membranes. The measured water permeability...
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| Veröffentlicht in: | RSC advances 2020-05, Vol.1 (33), p.19686-19692 |
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| container_issue | 33 |
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| container_title | RSC advances |
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| creator | Fleury, Jean-Baptiste |
| description | We measure the water permeability across a physiological lipid bilayer produced by the droplet interface bilayer (DiB) technique. This lipid bilayer can be considered as physiologically relevant because it presents a lipidic composition close to human cell membranes. The measured water permeability coefficients across this lipid bilayer are reported as a function of the cholesterol concentration. It is found that the water permeability coefficients decreased with increasing cholesterol concentration, in agreement with the existing literature. And, consistently, the extracted corresponding activation energies increase with increasing cholesterol concentration in the lipid bilayer. Hence having demonstrated the robustness of the experimental system, we extend this study by exploring the influence of fullerenes on the water permeability of a physiological lipid bilayer. Interestingly, we observe a significant increase of the measured water permeability coefficients across this lipid bilayer for large fullerenes concentration. This enhanced permeability might be related to the conductive properties of fullerenes.
We measure the water permeability across a physiological lipid bilayer produced by the droplet interface bilayer technique. |
| doi_str_mv | 10.1039/d0ra01413c |
| format | Article |
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We measure the water permeability across a physiological lipid bilayer produced by the droplet interface bilayer technique.</description><subject>Cell membranes</subject><subject>Chemistry</subject><subject>Cholesterol</subject><subject>Coefficients</subject><subject>Droplets</subject><subject>Fullerenes</subject><subject>Lipids</subject><subject>Permeability</subject><subject>Physiology</subject><subject>Potassium</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpdkd9rFDEQx4MottS--K4EfBHhNJlN0t0XoZz1BxQE0ecwyc72UnKbNdmt3H9v2qtndV4yMJ_58s18GXsuxVspmu5dLzIKqWTjH7FjEMqsQJju8YP-iJ2Wci1qGS3ByKfsqNFaagX6mLmLcYOjp57_wpkynyhvCV2IYd5x9DmVwpFPm10JKaar4DHyPqcp0szDWDcG9MQrj7u63afpVinMGz4sMVKmkcoz9mTAWOj0_j1hPz5efF9_Xl1-_fRlfX658graedV70WulyAyyk0Cic54ESpRKt9KZtjUAA3QSmzPhqEUE1w4GhHNkQDe6OWHv97rT4rbUexrnjNFOOWwx72zCYP-djGFjr9KN7YRWUnRV4PW9QE4_Fyqz3YbiKUYcKS3FgjFStCABKvrqP_Q6LXms37Og6s3hrFqq1Js9dXfHTMPBjBT2Nj37QXw7v0tvXeGXD-0f0D9ZVeDFHsjFH6Z_429-A70ioA0</recordid><startdate>20200522</startdate><enddate>20200522</enddate><creator>Fleury, Jean-Baptiste</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1878-0108</orcidid></search><sort><creationdate>20200522</creationdate><title>Enhanced water permeability across a physiological droplet interface bilayer doped with fullerenes</title><author>Fleury, Jean-Baptiste</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-dc0d544e6f1912e09bce0a1a14581b688622f291a370be8aa2b8f620bbe625353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cell membranes</topic><topic>Chemistry</topic><topic>Cholesterol</topic><topic>Coefficients</topic><topic>Droplets</topic><topic>Fullerenes</topic><topic>Lipids</topic><topic>Permeability</topic><topic>Physiology</topic><topic>Potassium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fleury, Jean-Baptiste</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fleury, Jean-Baptiste</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced water permeability across a physiological droplet interface bilayer doped with fullerenes</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2020-05-22</date><risdate>2020</risdate><volume>1</volume><issue>33</issue><spage>19686</spage><epage>19692</epage><pages>19686-19692</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>We measure the water permeability across a physiological lipid bilayer produced by the droplet interface bilayer (DiB) technique. This lipid bilayer can be considered as physiologically relevant because it presents a lipidic composition close to human cell membranes. The measured water permeability coefficients across this lipid bilayer are reported as a function of the cholesterol concentration. It is found that the water permeability coefficients decreased with increasing cholesterol concentration, in agreement with the existing literature. And, consistently, the extracted corresponding activation energies increase with increasing cholesterol concentration in the lipid bilayer. Hence having demonstrated the robustness of the experimental system, we extend this study by exploring the influence of fullerenes on the water permeability of a physiological lipid bilayer. Interestingly, we observe a significant increase of the measured water permeability coefficients across this lipid bilayer for large fullerenes concentration. This enhanced permeability might be related to the conductive properties of fullerenes.
We measure the water permeability across a physiological lipid bilayer produced by the droplet interface bilayer technique.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35515425</pmid><doi>10.1039/d0ra01413c</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1878-0108</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Cell membranes Chemistry Cholesterol Coefficients Droplets Fullerenes Lipids Permeability Physiology Potassium |
| title | Enhanced water permeability across a physiological droplet interface bilayer doped with fullerenes |
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