Caspase‑2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy

Synaptic and cognitive deficits mediated by a severe reduction in excitatory neurotransmission caused by a disproportionate accumulation of the neuronal protein tau in dendritic spines is a fundamental mechanism that has been found repeatedly in models of tauopathies, including Alzheimer’s disease,...

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Veröffentlicht in:	ACS chemical neuroscience 2022-05, Vol.13 (10), p.1549-1557
Hauptverfasser:	Singh, Gurpreet, Liu, Peng, Yao, Katherine R., Strasser, Jessica M., Hlynialuk, Chris, Leinonen-Wright, Kailee, Teravskis, Peter J., Choquette, Jessica M., Ikramuddin, Junaid, Bresinsky, Merlin, Nelson, Kathryn M., Liao, Dezhi, Ashe, Karen H., Walters, Michael A., Pockes, Steffen
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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