Metabolic perturbations and health impact from exposure to a combination of multiple harmful Maillard reaction products on Sprague-Dawley rats
The present study aimed to investigate the metabolic perturbations and health impact of the co-accumulation of Maillard reaction products (MRPs), including acrylamide, harmane, and N -(carboxymethyl)lysine (CML), via serum biochemical and histopathological examinations as well as metabolomic analysi...
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| Veröffentlicht in: | Food & function 2022-05, Vol.13 (1), p.5515-5527 |
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| creator | Quan, Wei Lin, Yong Xue, Chaoyi Cheng, Yong Luo, Jie Lou, Aihua Zeng, Maomao He, Zhiyong Shen, Qingwu Chen, Jie |
| description | The present study aimed to investigate the metabolic perturbations and health impact of the co-accumulation of Maillard reaction products (MRPs), including acrylamide, harmane, and
N
-(carboxymethyl)lysine (CML),
via
serum biochemical and histopathological examinations as well as metabolomic analysis. Sprague-Dawley rats were treated with acrylamide (2 mg per kg body weight [bw]), harmane (1 mg per kg bw), CML (2 mg per kg bw), and combinations of these MRPs. Harmane did not cause adverse effects on the health of rats, whereas acrylamide and CML resulted in significantly (
P
< 0.05) decreased insulin sensitivity (HOMA-IR > 1), increased oxidative stress levels, and pathological injuries to the pancreas, liver, and gastrocnemius. Owing to the antioxidant and anti-diabetic activities of harmane, the effects of the combination of the MRPs on oxidative stress levels, blood glucose metabolism, and pathological injuries to the pancreas and gastrocnemius were relieved. However, new health problems, including pathological injury of the kidneys and increased cancer risk, were observed. Metabolomic analysis revealed that this may be related to the effects of MRPs on the arginine biosynthesis pathway, which resulted in the abnormal metabolism of fumaric acid and the tricarboxylic acid cycle. These results indicated that the mechanisms of the combined effect of MRPs and their effects on health cannot be predicted from the effects of individual MRPs.
The metabolic perturbations and health impact of the co-accumulation of acrylamide, harmane, and N -(carboxymethyl)lysine was investigated
via
serum biochemical and histopathological examinations as well as metabolomic analysis. |
| doi_str_mv | 10.1039/d2fo00143h |
| format | Article |
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N
-(carboxymethyl)lysine (CML),
via
serum biochemical and histopathological examinations as well as metabolomic analysis. Sprague-Dawley rats were treated with acrylamide (2 mg per kg body weight [bw]), harmane (1 mg per kg bw), CML (2 mg per kg bw), and combinations of these MRPs. Harmane did not cause adverse effects on the health of rats, whereas acrylamide and CML resulted in significantly (
P
< 0.05) decreased insulin sensitivity (HOMA-IR > 1), increased oxidative stress levels, and pathological injuries to the pancreas, liver, and gastrocnemius. Owing to the antioxidant and anti-diabetic activities of harmane, the effects of the combination of the MRPs on oxidative stress levels, blood glucose metabolism, and pathological injuries to the pancreas and gastrocnemius were relieved. However, new health problems, including pathological injury of the kidneys and increased cancer risk, were observed. Metabolomic analysis revealed that this may be related to the effects of MRPs on the arginine biosynthesis pathway, which resulted in the abnormal metabolism of fumaric acid and the tricarboxylic acid cycle. These results indicated that the mechanisms of the combined effect of MRPs and their effects on health cannot be predicted from the effects of individual MRPs.
The metabolic perturbations and health impact of the co-accumulation of acrylamide, harmane, and N -(carboxymethyl)lysine was investigated
via
serum biochemical and histopathological examinations as well as metabolomic analysis.</description><identifier>ISSN: 2042-6496</identifier><identifier>EISSN: 2042-650X</identifier><identifier>DOI: 10.1039/d2fo00143h</identifier><identifier>PMID: 35522130</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Acrylamide ; Antioxidants ; Biosynthesis ; Blood glucose ; Body weight ; Carboxymethyllysine ; Diabetes mellitus ; Fumaric acid ; Glucose metabolism ; Health problems ; Health risks ; Injuries ; Insulin ; Kidneys ; Lysine ; Maillard reaction ; Maillard reaction products ; Metabolism ; Metabolomics ; Oxidative stress ; Pancreas ; Perturbation ; Tricarboxylic acid cycle</subject><ispartof>Food & function, 2022-05, Vol.13 (1), p.5515-5527</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-be9c45febda0b8d9aeb68318b0fb08d25530343d7f459f5859657696fca4bc3</citedby><cites>FETCH-LOGICAL-c337t-be9c45febda0b8d9aeb68318b0fb08d25530343d7f459f5859657696fca4bc3</cites><orcidid>0000-0001-9259-1992 ; 0000-0003-3917-1686 ; 0000-0003-3882-7284 ; 0000-0003-1273-2965</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35522130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quan, Wei</creatorcontrib><creatorcontrib>Lin, Yong</creatorcontrib><creatorcontrib>Xue, Chaoyi</creatorcontrib><creatorcontrib>Cheng, Yong</creatorcontrib><creatorcontrib>Luo, Jie</creatorcontrib><creatorcontrib>Lou, Aihua</creatorcontrib><creatorcontrib>Zeng, Maomao</creatorcontrib><creatorcontrib>He, Zhiyong</creatorcontrib><creatorcontrib>Shen, Qingwu</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><title>Metabolic perturbations and health impact from exposure to a combination of multiple harmful Maillard reaction products on Sprague-Dawley rats</title><title>Food & function</title><addtitle>Food Funct</addtitle><description>The present study aimed to investigate the metabolic perturbations and health impact of the co-accumulation of Maillard reaction products (MRPs), including acrylamide, harmane, and
N
-(carboxymethyl)lysine (CML),
via
serum biochemical and histopathological examinations as well as metabolomic analysis. Sprague-Dawley rats were treated with acrylamide (2 mg per kg body weight [bw]), harmane (1 mg per kg bw), CML (2 mg per kg bw), and combinations of these MRPs. Harmane did not cause adverse effects on the health of rats, whereas acrylamide and CML resulted in significantly (
P
< 0.05) decreased insulin sensitivity (HOMA-IR > 1), increased oxidative stress levels, and pathological injuries to the pancreas, liver, and gastrocnemius. Owing to the antioxidant and anti-diabetic activities of harmane, the effects of the combination of the MRPs on oxidative stress levels, blood glucose metabolism, and pathological injuries to the pancreas and gastrocnemius were relieved. However, new health problems, including pathological injury of the kidneys and increased cancer risk, were observed. Metabolomic analysis revealed that this may be related to the effects of MRPs on the arginine biosynthesis pathway, which resulted in the abnormal metabolism of fumaric acid and the tricarboxylic acid cycle. These results indicated that the mechanisms of the combined effect of MRPs and their effects on health cannot be predicted from the effects of individual MRPs.
The metabolic perturbations and health impact of the co-accumulation of acrylamide, harmane, and N -(carboxymethyl)lysine was investigated
via
serum biochemical and histopathological examinations as well as metabolomic analysis.</description><subject>Acrylamide</subject><subject>Antioxidants</subject><subject>Biosynthesis</subject><subject>Blood glucose</subject><subject>Body weight</subject><subject>Carboxymethyllysine</subject><subject>Diabetes mellitus</subject><subject>Fumaric acid</subject><subject>Glucose metabolism</subject><subject>Health problems</subject><subject>Health risks</subject><subject>Injuries</subject><subject>Insulin</subject><subject>Kidneys</subject><subject>Lysine</subject><subject>Maillard reaction</subject><subject>Maillard reaction products</subject><subject>Metabolism</subject><subject>Metabolomics</subject><subject>Oxidative stress</subject><subject>Pancreas</subject><subject>Perturbation</subject><subject>Tricarboxylic acid cycle</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpd0U1LHTEUBuAgLSrWTfctgW5KYWpmMskky6K1FhQXuuhuyMdJ70hmMs0H1j_R39xcr1poNjmQJ4cXXoTetuRzS6g8sZ0LhLQ93eyhw470XcMZ-fHqee4lP0DHKd2ReqiUQop9dEAZ67qWkkP05wqy0sFPBq8Qc4la5SksCavF4g0onzd4mldlMnYxzBh-ryGVCDgHrLAJs56Wxx84ODwXn6fVA96oOLvi8ZWavFfR4gh1w1atMdhicsJ1vlmj-lmgOVP3Hh5wVDm9Qa-d8gmOn-4jdHP-9fb0orm8_vb99MtlYygdcqNBmp450FYRLaxUoLmgrdDEaSJsxxgltKd2cD2TjgkmORu45M6oXht6hD7uttY0vwqkPM5TMlCjLhBKGjvOWzKIVvBKP_xH70KJS822VcMg-SCGqj7tlIkhpQhuXOM0q_gwtmTc1jSedefXjzVdVPz-aWXRM9gX-lxKBe92ICbz8vqvZ_oXbOmZlg</recordid><startdate>20220523</startdate><enddate>20220523</enddate><creator>Quan, Wei</creator><creator>Lin, Yong</creator><creator>Xue, Chaoyi</creator><creator>Cheng, Yong</creator><creator>Luo, Jie</creator><creator>Lou, Aihua</creator><creator>Zeng, Maomao</creator><creator>He, Zhiyong</creator><creator>Shen, Qingwu</creator><creator>Chen, Jie</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9259-1992</orcidid><orcidid>https://orcid.org/0000-0003-3917-1686</orcidid><orcidid>https://orcid.org/0000-0003-3882-7284</orcidid><orcidid>https://orcid.org/0000-0003-1273-2965</orcidid></search><sort><creationdate>20220523</creationdate><title>Metabolic perturbations and health impact from exposure to a combination of multiple harmful Maillard reaction products on Sprague-Dawley rats</title><author>Quan, Wei ; Lin, Yong ; Xue, Chaoyi ; Cheng, Yong ; Luo, Jie ; Lou, Aihua ; Zeng, Maomao ; He, Zhiyong ; Shen, Qingwu ; Chen, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-be9c45febda0b8d9aeb68318b0fb08d25530343d7f459f5859657696fca4bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acrylamide</topic><topic>Antioxidants</topic><topic>Biosynthesis</topic><topic>Blood glucose</topic><topic>Body weight</topic><topic>Carboxymethyllysine</topic><topic>Diabetes mellitus</topic><topic>Fumaric acid</topic><topic>Glucose metabolism</topic><topic>Health problems</topic><topic>Health risks</topic><topic>Injuries</topic><topic>Insulin</topic><topic>Kidneys</topic><topic>Lysine</topic><topic>Maillard reaction</topic><topic>Maillard reaction products</topic><topic>Metabolism</topic><topic>Metabolomics</topic><topic>Oxidative stress</topic><topic>Pancreas</topic><topic>Perturbation</topic><topic>Tricarboxylic acid cycle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quan, Wei</creatorcontrib><creatorcontrib>Lin, Yong</creatorcontrib><creatorcontrib>Xue, Chaoyi</creatorcontrib><creatorcontrib>Cheng, Yong</creatorcontrib><creatorcontrib>Luo, Jie</creatorcontrib><creatorcontrib>Lou, Aihua</creatorcontrib><creatorcontrib>Zeng, Maomao</creatorcontrib><creatorcontrib>He, Zhiyong</creatorcontrib><creatorcontrib>Shen, Qingwu</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quan, Wei</au><au>Lin, Yong</au><au>Xue, Chaoyi</au><au>Cheng, Yong</au><au>Luo, Jie</au><au>Lou, Aihua</au><au>Zeng, Maomao</au><au>He, Zhiyong</au><au>Shen, Qingwu</au><au>Chen, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic perturbations and health impact from exposure to a combination of multiple harmful Maillard reaction products on Sprague-Dawley rats</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2022-05-23</date><risdate>2022</risdate><volume>13</volume><issue>1</issue><spage>5515</spage><epage>5527</epage><pages>5515-5527</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>The present study aimed to investigate the metabolic perturbations and health impact of the co-accumulation of Maillard reaction products (MRPs), including acrylamide, harmane, and
N
-(carboxymethyl)lysine (CML),
via
serum biochemical and histopathological examinations as well as metabolomic analysis. Sprague-Dawley rats were treated with acrylamide (2 mg per kg body weight [bw]), harmane (1 mg per kg bw), CML (2 mg per kg bw), and combinations of these MRPs. Harmane did not cause adverse effects on the health of rats, whereas acrylamide and CML resulted in significantly (
P
< 0.05) decreased insulin sensitivity (HOMA-IR > 1), increased oxidative stress levels, and pathological injuries to the pancreas, liver, and gastrocnemius. Owing to the antioxidant and anti-diabetic activities of harmane, the effects of the combination of the MRPs on oxidative stress levels, blood glucose metabolism, and pathological injuries to the pancreas and gastrocnemius were relieved. However, new health problems, including pathological injury of the kidneys and increased cancer risk, were observed. Metabolomic analysis revealed that this may be related to the effects of MRPs on the arginine biosynthesis pathway, which resulted in the abnormal metabolism of fumaric acid and the tricarboxylic acid cycle. These results indicated that the mechanisms of the combined effect of MRPs and their effects on health cannot be predicted from the effects of individual MRPs.
The metabolic perturbations and health impact of the co-accumulation of acrylamide, harmane, and N -(carboxymethyl)lysine was investigated
via
serum biochemical and histopathological examinations as well as metabolomic analysis.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35522130</pmid><doi>10.1039/d2fo00143h</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-9259-1992</orcidid><orcidid>https://orcid.org/0000-0003-3917-1686</orcidid><orcidid>https://orcid.org/0000-0003-3882-7284</orcidid><orcidid>https://orcid.org/0000-0003-1273-2965</orcidid></addata></record> |
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| ispartof | Food & function, 2022-05, Vol.13 (1), p.5515-5527 |
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| source | Royal Society Of Chemistry Journals |
| subjects | Acrylamide Antioxidants Biosynthesis Blood glucose Body weight Carboxymethyllysine Diabetes mellitus Fumaric acid Glucose metabolism Health problems Health risks Injuries Insulin Kidneys Lysine Maillard reaction Maillard reaction products Metabolism Metabolomics Oxidative stress Pancreas Perturbation Tricarboxylic acid cycle |
| title | Metabolic perturbations and health impact from exposure to a combination of multiple harmful Maillard reaction products on Sprague-Dawley rats |
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