OTUD7B (Cezanne) ameliorates fibrosis after myocardial infarction via FAK-ERK/P38 MAPK signaling pathway

Fibrosis is one of the crucial reasons for cardiac dysfunction after myocardial infarction (MI). Understanding the underlying molecular mechanism that causes fibrosis is crucial to developing effective therapy. Recently, OUT domain-containing 7B (OTUD7B), also called Cezanne, a multifunctional deubi...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2022-07, Vol.724, p.109266-109266, Article 109266
Hauptverfasser:	Zhang, Jiayan, Zha, Yafang, Jiao, Yuheng, Li, Yanyan, Wang, Jian, Zhang, Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiac fibrosis Collagen Type I - metabolism Endopeptidases - metabolism FAK-ERK/P38 signaling pathway Fibroblasts - metabolism Fibrosis Focal Adhesion Protein-Tyrosine Kinases - metabolism Myocardial infarction Myocardial Infarction - metabolism Myocardium - metabolism OTUD7B p38 Mitogen-Activated Protein Kinases - metabolism Rats RNA, Small Interfering - metabolism Signal Transduction Transforming Growth Factor beta1 - metabolism
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