Epigenetic lockdown of CDKN1A (p21) and CDKN2A (p16) characterises the neoplastic spindle cell component of giant cell tumours of bone

Giant cell tumour of bone (GCTB) comprises the eponymous osteoclastic multinucleated giant cells eliciting bone lysis, an H3F3A‐mutated neoplastic mononucleated fibroblast‐like cell population, and H3F3A wild‐type mononucleated stromal cells. In this study, we characterised four new cell lines from...

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Veröffentlicht in:	The Journal of pathology 2022-08, Vol.257 (5), p.687-696
Hauptverfasser:	Giesche, Julian, Mellert, Kevin, Geißler, Sven, Arndt, Sophia, Seeling, Carolin, Baer, Alexandra, Schultheiss, Markus, Marienfeld, Ralf, Möller, Peter, Barth, Thomas FE
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysm bone Bone tumors CDKN1A CDKN2A Collagen Cyclin-dependent kinase inhibitor p21 DNA methylation epigenetic silencing Epigenetics Gene expression Genomes giant cell tumour of bone Giant cells H3F3A mutation histone Histones Hyperparathyroidism Insulin-like growth factor-binding protein 3 Lysis Mesenchyme Osteoblasts Osteoclasts p53 Protein promotor hypermethylation Stem cells Stromal cells Tumor suppressor genes Tumors
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