The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans
Common metabolic diseases such as obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease significantly contribute to morbidity and mortality worldwide. They frequently associate with insulin resistance and altered mitochondrial functionality. Insulin-responsive tissues can show chan...
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| Veröffentlicht in: | American Journal of Physiology: Cell Physiology 2022-06, Vol.322 (6), p.C1248-C1259 |
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| container_end_page | C1259 |
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| container_issue | 6 |
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| container_title | American Journal of Physiology: Cell Physiology |
| container_volume | 322 |
| creator | Georgiev, Asen Granata, Cesare Roden, Michael |
| description | Common metabolic diseases such as obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease significantly contribute to morbidity and mortality worldwide. They frequently associate with insulin resistance and altered mitochondrial functionality. Insulin-responsive tissues can show changes in mitochondrial features such as oxidative capacity, mitochondrial content and turnover, which do not necessarily reflect abnormalities but rather adaption to a certain metabolic condition. Lifestyle modifications and classic or novel drugs can modify these alterations and help treating these metabolic diseases. This review addresses the role of mitochondria in human metabolic diseases and discusses potential future research directions. |
| doi_str_mv | 10.1152/ajpcell.00035.2022 |
| format | Article |
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This review addresses the role of mitochondria in human metabolic diseases and discusses potential future research directions.</description><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Fatty liver</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Liver diseases</subject><subject>Metabolic disorders</subject><subject>Mitochondria</subject><subject>Morbidity</subject><issn>0363-6143</issn><issn>1522-1563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkTtv3DAQhIkggX2x_QdSBATSuNGFD1GiSsOwkwAHpLFrgY9lpIMoKiRV3L83FZ9dpNpivxnsziD0hZI9pYJ9V8fFwDTtCSFc7Blh7APalQWrqGj4R7QjvOFVQ2t-iT6ndCxczZruAl1yIYikHd0h-zQAjmECHBz2Yw5mCLONo8LjjHPZLSoPYRlOaQxT-HPCarY4R1DZw5w3kQnehxl7yEqHaTTYjglUgrQ5DKtXc7pGn5yaEtyc5xV6fnx4uv9ZHX7_-HV_d6gM5zRXQtaGWMGNI63lREvd1q2R1onyIBM16axpWgKy1XXtpJGaOQPQOO2IBt3yK3T76rvE8HeFlHs_pi0iNUNYU8-ahtCSVccK-u0_9BjWOJfrCiWp7NqObobslTIxpBTB9UscvYqnnpJ-66A_d9D_66DfOiiir2frVXuw75K30PkL91mE1A</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Georgiev, Asen</creator><creator>Granata, Cesare</creator><creator>Roden, Michael</creator><general>American Physiological Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3509-6001</orcidid><orcidid>https://orcid.org/0000-0001-8200-6382</orcidid></search><sort><creationdate>20220601</creationdate><title>The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans</title><author>Georgiev, Asen ; Granata, Cesare ; Roden, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-584c0d53cf07d30b8b747c8df500325409dc670e87b44f8c8b2fcee6fbf0beb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Fatty liver</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Liver diseases</topic><topic>Metabolic disorders</topic><topic>Mitochondria</topic><topic>Morbidity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Georgiev, Asen</creatorcontrib><creatorcontrib>Granata, Cesare</creatorcontrib><creatorcontrib>Roden, Michael</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>American Journal of Physiology: Cell Physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Georgiev, Asen</au><au>Granata, Cesare</au><au>Roden, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans</atitle><jtitle>American Journal of Physiology: Cell Physiology</jtitle><addtitle>Am J Physiol Cell Physiol</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>322</volume><issue>6</issue><spage>C1248</spage><epage>C1259</epage><pages>C1248-C1259</pages><issn>0363-6143</issn><eissn>1522-1563</eissn><abstract>Common metabolic diseases such as obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease significantly contribute to morbidity and mortality worldwide. 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| issn | 0363-6143 1522-1563 |
| language | eng |
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| source | American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Diabetes mellitus (non-insulin dependent) Fatty liver Insulin Insulin resistance Liver diseases Metabolic disorders Mitochondria Morbidity |
| title | The role of mitochondria in the pathophysiology and treatment of common metabolic diseases in humans |
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