Convergent Evolution of Multiple Mutations Improves the Viral Fitness of SARS-CoV‑2 Variants by Balancing Positive and Negative Selection

Multiple mutations have been seen to undergo convergent evolution in SARS-CoV-2 variants of concern. One such evolution occurs in Beta, Gamma, and Omicron variants at three amino acid positions K417, E484, and N501 in the receptor binding domain of the spike protein. We examined the physical mechani...

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Veröffentlicht in:	Biochemistry (Easton) 2022-06, Vol.61 (11), p.963-980
Hauptverfasser:	Upadhyay, Vaibhav, Patrick, Casey, Lucas, Alexandra, Mallela, Krishna M. G.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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