Ocular blood flow and retinal, choroidal, and retinal nerve fiber layer thickness in children with familial Mediterranean fever with at least five attacks
Purpose This study aimed to evaluate ocular blood flow and, retinal, choroidal and retinal nerve fiber layer thickness in children with familial Mediterranean fever (FMF) with patients who had at least five attacks. Methods Fifty-six patients with FMF and 56 healthy subjects were enrolled in the stu...
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| Veröffentlicht in: | International ophthalmology 2022-10, Vol.42 (10), p.3109-3116 |
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| description | Purpose
This study aimed to evaluate ocular blood flow and, retinal, choroidal and retinal nerve fiber layer thickness in children with familial Mediterranean fever (FMF) with patients who had at least five attacks.
Methods
Fifty-six patients with FMF and 56 healthy subjects were enrolled in the study. Each participant’s choroidal thickness (CT) and retinal thickness (RT) measurements were performed in the foveola and at horizontal nasal and temporal quadrants within 500-μm intervals up to 1.500 μm from the foveola using spectral-domain optical coherence tomography as well as the retinal nerve fiber layer thickness (RNFLT). Disc boundaries were determined manually by identifying seven points on the inner edge of the scleral ring. Following complete ophthalmological evaluation, peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistivity index (RI) values in the central retinal artery (CRA), ophthalmic artery (OA), and nasal posterior ciliary artery (NPCA) were measured using color Doppler ultrasonography (CDU) in the left eyes of the patients diagnosed with FMF and the controls. The results were subsequently compared.
Results
No statistically significant differences were observed between the groups in terms of all RNFLT quadrant and RT measurements. All CT measurements were thinner in patients with FMF than in the controls (For Central and Temporal_1500
p
= 0.01; For Temporal_500, Nasal 500 and Nasal_1000
p
|
| doi_str_mv | 10.1007/s10792-022-02310-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2660099895</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2717355537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-5475a4bfc229dcf4535b30c2d5c1aaaac80812eb7ea6d9df83c60ced1ecf62a13</originalsourceid><addsrcrecordid>eNp9kc1uVSEUhYnR2Fp9AQeGxImDHuXncjgMTaPVpE0ndUw4sPHScqECp01fxaeV21u16aAkwA58a0H2QugtJR8pIfJTpUQqNhC2nZySQT1D-1RIPrCRk-cP6j30qtYLQoiSanyJ9rgQlHI67aPfZ3aJpuA55uywj_kGm-RwgRaSiYfYrnPJwW3LB-c4QbkG7MMMBUdz29e2DvYyQa04pK4K0RVI-Ca0NfZmE2LoqlNwoUEpJoFJ2MN1190RpuEIprbu2G1Na8Ze1tfohTexwpv7_QD9-Prl_OjbcHJ2_P3o88lguRRtECspzGr2ljHlrF8JLmZOLHPCUtOHnchEGcwSzOiU8xO3I7HgKFg_MkP5Afqw870q-dcCtelNqBZi7N_MS9VsHHvj1KRER98_Qi_yUnpDOiWp7G0VXHaK7Shbcq0FvL4qYWPKraZEb5PTu-R0T07fJadVF727t17mDbh_kr9RdYDvgNqv0k8o_99-wvYPZAWmog</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2717355537</pqid></control><display><type>article</type><title>Ocular blood flow and retinal, choroidal, and retinal nerve fiber layer thickness in children with familial Mediterranean fever with at least five attacks</title><source>SpringerLink Journals</source><creator>Eski, Mehmet Tahir ; Oktay, Mehtap</creator><creatorcontrib>Eski, Mehmet Tahir ; Oktay, Mehtap</creatorcontrib><description>Purpose
This study aimed to evaluate ocular blood flow and, retinal, choroidal and retinal nerve fiber layer thickness in children with familial Mediterranean fever (FMF) with patients who had at least five attacks.
Methods
Fifty-six patients with FMF and 56 healthy subjects were enrolled in the study. Each participant’s choroidal thickness (CT) and retinal thickness (RT) measurements were performed in the foveola and at horizontal nasal and temporal quadrants within 500-μm intervals up to 1.500 μm from the foveola using spectral-domain optical coherence tomography as well as the retinal nerve fiber layer thickness (RNFLT). Disc boundaries were determined manually by identifying seven points on the inner edge of the scleral ring. Following complete ophthalmological evaluation, peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistivity index (RI) values in the central retinal artery (CRA), ophthalmic artery (OA), and nasal posterior ciliary artery (NPCA) were measured using color Doppler ultrasonography (CDU) in the left eyes of the patients diagnosed with FMF and the controls. The results were subsequently compared.
Results
No statistically significant differences were observed between the groups in terms of all RNFLT quadrant and RT measurements. All CT measurements were thinner in patients with FMF than in the controls (For Central and Temporal_1500
p
= 0.01; For Temporal_500, Nasal 500 and Nasal_1000
p
< 0.001; Temporal_1000
p
= 0.002) except than the Nasal_1500 point. For nasal_1500
p
= 0.121). The PSV and EDV values in the OA, CRA, and NPCA were significantly lower in patients with FMF compared to healthy controls (
p
< 0.001 for all). In contrast, the RI values of all arteries were significantly higher than in the control group (Regarding OA, CRA and NPCA RI,
p
= 0.003,
p
= 0.039, and
p
= 0.039, respectively).
Conclusions
The results of this study support the idea that chronic inflammation and frequent attacks in FMF may have an effect on decreased ocular blood flow and choroidal thinning.</description><identifier>ISSN: 1573-2630</identifier><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-022-02310-9</identifier><identifier>PMID: 35511318</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Arteries ; Blood flow ; Color vision ; Doppler effect ; Evaluation ; Familial Mediterranean fever ; Fever ; Horizontal cells ; Medicine ; Medicine & Public Health ; Nerves ; Ophthalmology ; Original Paper ; Quadrants ; Retina ; Statistical analysis ; Thickness measurement ; Veins & arteries ; Velocity</subject><ispartof>International ophthalmology, 2022-10, Vol.42 (10), p.3109-3116</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-5475a4bfc229dcf4535b30c2d5c1aaaac80812eb7ea6d9df83c60ced1ecf62a13</citedby><cites>FETCH-LOGICAL-c375t-5475a4bfc229dcf4535b30c2d5c1aaaac80812eb7ea6d9df83c60ced1ecf62a13</cites><orcidid>0000-0001-8393-1246</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-022-02310-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-022-02310-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35511318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eski, Mehmet Tahir</creatorcontrib><creatorcontrib>Oktay, Mehtap</creatorcontrib><title>Ocular blood flow and retinal, choroidal, and retinal nerve fiber layer thickness in children with familial Mediterranean fever with at least five attacks</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
This study aimed to evaluate ocular blood flow and, retinal, choroidal and retinal nerve fiber layer thickness in children with familial Mediterranean fever (FMF) with patients who had at least five attacks.
Methods
Fifty-six patients with FMF and 56 healthy subjects were enrolled in the study. Each participant’s choroidal thickness (CT) and retinal thickness (RT) measurements were performed in the foveola and at horizontal nasal and temporal quadrants within 500-μm intervals up to 1.500 μm from the foveola using spectral-domain optical coherence tomography as well as the retinal nerve fiber layer thickness (RNFLT). Disc boundaries were determined manually by identifying seven points on the inner edge of the scleral ring. Following complete ophthalmological evaluation, peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistivity index (RI) values in the central retinal artery (CRA), ophthalmic artery (OA), and nasal posterior ciliary artery (NPCA) were measured using color Doppler ultrasonography (CDU) in the left eyes of the patients diagnosed with FMF and the controls. The results were subsequently compared.
Results
No statistically significant differences were observed between the groups in terms of all RNFLT quadrant and RT measurements. All CT measurements were thinner in patients with FMF than in the controls (For Central and Temporal_1500
p
= 0.01; For Temporal_500, Nasal 500 and Nasal_1000
p
< 0.001; Temporal_1000
p
= 0.002) except than the Nasal_1500 point. For nasal_1500
p
= 0.121). The PSV and EDV values in the OA, CRA, and NPCA were significantly lower in patients with FMF compared to healthy controls (
p
< 0.001 for all). In contrast, the RI values of all arteries were significantly higher than in the control group (Regarding OA, CRA and NPCA RI,
p
= 0.003,
p
= 0.039, and
p
= 0.039, respectively).
Conclusions
The results of this study support the idea that chronic inflammation and frequent attacks in FMF may have an effect on decreased ocular blood flow and choroidal thinning.</description><subject>Arteries</subject><subject>Blood flow</subject><subject>Color vision</subject><subject>Doppler effect</subject><subject>Evaluation</subject><subject>Familial Mediterranean fever</subject><subject>Fever</subject><subject>Horizontal cells</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nerves</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Quadrants</subject><subject>Retina</subject><subject>Statistical analysis</subject><subject>Thickness measurement</subject><subject>Veins & arteries</subject><subject>Velocity</subject><issn>1573-2630</issn><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1uVSEUhYnR2Fp9AQeGxImDHuXncjgMTaPVpE0ndUw4sPHScqECp01fxaeV21u16aAkwA58a0H2QugtJR8pIfJTpUQqNhC2nZySQT1D-1RIPrCRk-cP6j30qtYLQoiSanyJ9rgQlHI67aPfZ3aJpuA55uywj_kGm-RwgRaSiYfYrnPJwW3LB-c4QbkG7MMMBUdz29e2DvYyQa04pK4K0RVI-Ca0NfZmE2LoqlNwoUEpJoFJ2MN1190RpuEIprbu2G1Na8Ze1tfohTexwpv7_QD9-Prl_OjbcHJ2_P3o88lguRRtECspzGr2ljHlrF8JLmZOLHPCUtOHnchEGcwSzOiU8xO3I7HgKFg_MkP5Afqw870q-dcCtelNqBZi7N_MS9VsHHvj1KRER98_Qi_yUnpDOiWp7G0VXHaK7Shbcq0FvL4qYWPKraZEb5PTu-R0T07fJadVF727t17mDbh_kr9RdYDvgNqv0k8o_99-wvYPZAWmog</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Eski, Mehmet Tahir</creator><creator>Oktay, Mehtap</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8393-1246</orcidid></search><sort><creationdate>20221001</creationdate><title>Ocular blood flow and retinal, choroidal, and retinal nerve fiber layer thickness in children with familial Mediterranean fever with at least five attacks</title><author>Eski, Mehmet Tahir ; Oktay, Mehtap</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-5475a4bfc229dcf4535b30c2d5c1aaaac80812eb7ea6d9df83c60ced1ecf62a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arteries</topic><topic>Blood flow</topic><topic>Color vision</topic><topic>Doppler effect</topic><topic>Evaluation</topic><topic>Familial Mediterranean fever</topic><topic>Fever</topic><topic>Horizontal cells</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nerves</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Quadrants</topic><topic>Retina</topic><topic>Statistical analysis</topic><topic>Thickness measurement</topic><topic>Veins & arteries</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eski, Mehmet Tahir</creatorcontrib><creatorcontrib>Oktay, Mehtap</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eski, Mehmet Tahir</au><au>Oktay, Mehtap</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ocular blood flow and retinal, choroidal, and retinal nerve fiber layer thickness in children with familial Mediterranean fever with at least five attacks</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>42</volume><issue>10</issue><spage>3109</spage><epage>3116</epage><pages>3109-3116</pages><issn>1573-2630</issn><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
This study aimed to evaluate ocular blood flow and, retinal, choroidal and retinal nerve fiber layer thickness in children with familial Mediterranean fever (FMF) with patients who had at least five attacks.
Methods
Fifty-six patients with FMF and 56 healthy subjects were enrolled in the study. Each participant’s choroidal thickness (CT) and retinal thickness (RT) measurements were performed in the foveola and at horizontal nasal and temporal quadrants within 500-μm intervals up to 1.500 μm from the foveola using spectral-domain optical coherence tomography as well as the retinal nerve fiber layer thickness (RNFLT). Disc boundaries were determined manually by identifying seven points on the inner edge of the scleral ring. Following complete ophthalmological evaluation, peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistivity index (RI) values in the central retinal artery (CRA), ophthalmic artery (OA), and nasal posterior ciliary artery (NPCA) were measured using color Doppler ultrasonography (CDU) in the left eyes of the patients diagnosed with FMF and the controls. The results were subsequently compared.
Results
No statistically significant differences were observed between the groups in terms of all RNFLT quadrant and RT measurements. All CT measurements were thinner in patients with FMF than in the controls (For Central and Temporal_1500
p
= 0.01; For Temporal_500, Nasal 500 and Nasal_1000
p
< 0.001; Temporal_1000
p
= 0.002) except than the Nasal_1500 point. For nasal_1500
p
= 0.121). The PSV and EDV values in the OA, CRA, and NPCA were significantly lower in patients with FMF compared to healthy controls (
p
< 0.001 for all). In contrast, the RI values of all arteries were significantly higher than in the control group (Regarding OA, CRA and NPCA RI,
p
= 0.003,
p
= 0.039, and
p
= 0.039, respectively).
Conclusions
The results of this study support the idea that chronic inflammation and frequent attacks in FMF may have an effect on decreased ocular blood flow and choroidal thinning.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>35511318</pmid><doi>10.1007/s10792-022-02310-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8393-1246</orcidid></addata></record> |
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| language | eng |
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| source | SpringerLink Journals |
| subjects | Arteries Blood flow Color vision Doppler effect Evaluation Familial Mediterranean fever Fever Horizontal cells Medicine Medicine & Public Health Nerves Ophthalmology Original Paper Quadrants Retina Statistical analysis Thickness measurement Veins & arteries Velocity |
| title | Ocular blood flow and retinal, choroidal, and retinal nerve fiber layer thickness in children with familial Mediterranean fever with at least five attacks |
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