Risk Factors Associated With New-Onset Myocardial Perfusion Abnormalities in Kidney Transplant Candidates

The optimal coronary artery disease surveillance strategy for end-stage renal disease patients being evaluated for kidney transplantation is unknown. It is unclear what risk factors are associated with the development of new-onset perfusion abnormalities on serial myocardial perfusion imaging. Poten...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The American journal of cardiology 2022-07, Vol.174, p.84-88
Hauptverfasser: Godwin, Lehman, Zheng, Ziduo, Kundu, Suprateek, Cousins, Ryan, Mullinax, Billy Joe, Ko, Yi-An, Little, Kendra, Smith, Andrew, Quyyumi, Arshed, Goyal, Abhinav, Pearson, Thomas, Moncayo, Valeria, Mitchell, Adam J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 88
container_issue
container_start_page 84
container_title The American journal of cardiology
container_volume 174
creator Godwin, Lehman
Zheng, Ziduo
Kundu, Suprateek
Cousins, Ryan
Mullinax, Billy Joe
Ko, Yi-An
Little, Kendra
Smith, Andrew
Quyyumi, Arshed
Goyal, Abhinav
Pearson, Thomas
Moncayo, Valeria
Mitchell, Adam J.
description The optimal coronary artery disease surveillance strategy for end-stage renal disease patients being evaluated for kidney transplantation is unknown. It is unclear what risk factors are associated with the development of new-onset perfusion abnormalities on serial myocardial perfusion imaging. Potential kidney transplant recipients who underwent 2 myocardial perfusion imaging studies at Emory University Hospital between January 2010 and December 2019 were identified. We assessed the frequency of development of any new perfusion defect and development of moderate to severe ischemia (reversible perfusion defect >10%) on serial imaging. Finally, we identified the clinical and imaging factors associated with new perfusion defects and explored the association between new perfusion defects and all-cause mortality. History of myocardial infarction (MI) and peripheral artery disease was associated with an increased risk of developing a new perfusion defect. History of MI was also associated with the risk of developing moderate-severe ischemia. Female patients were less likely to develop new perfusion defects or moderate-severe ischemia. There was no association between either outcome and all-cause mortality. In conclusion, a history of MI, peripheral artery disease, and male gender are risk factors for developing new perfusion defects, although only the history of MI and male gender predict moderate to severe ischemia. Interval development of any abnormal perfusion is not associated with increased mortality.
doi_str_mv 10.1016/j.amjcard.2022.03.030
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2659606096</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002914922003320</els_id><sourcerecordid>2669517393</sourcerecordid><originalsourceid>FETCH-LOGICAL-c341t-be722419b72f29575bfdce61a05ca42e70ea70bff85ace2362bf506e3c01b48e3</originalsourceid><addsrcrecordid>eNqFkUGLFDEQhYMo7uzqT1ACXrz0WEk66clJhsF1xdUVWfEY0ulqTNudjEm3Mv_eDDN68CIUFAVfvXrUI-QZgzUDpl4NazsNzqZuzYHzNYhS8ICs2KbRFdNMPCQrAOCVZrW-IJc5D2VkTKrH5EJICXVTixXxn33-Tq-tm2PKdJtzdN7O2NGvfv5GP-Kv6i5knOmHQzwe83aknzD1S_Yx0G0bYprs6GePmfpA3_su4IHeJxvyfrRhpjsbOt8VxfyEPOrtmPHpuV-RL9dv7nc31e3d23e77W3lRM3mqsWG85rptuE917KRbd85VMyCdLbm2ADaBtq-30jrkAvF216CQuGAtfUGxRV5edLdp_hjwTybyWeHY7GDccmGK6kVKNCqoC_-QYe4pFDcFUppyRqhRaHkiXIp5pywN_vkJ5sOhoE5ZmEGc87CHLMwIEpB2Xt-Vl_aCbu_W3-eX4DXJwDLO356TCY7j8Fh5xO62XTR_-fEb2P-nYs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2669517393</pqid></control><display><type>article</type><title>Risk Factors Associated With New-Onset Myocardial Perfusion Abnormalities in Kidney Transplant Candidates</title><source>Elsevier ScienceDirect Journals</source><creator>Godwin, Lehman ; Zheng, Ziduo ; Kundu, Suprateek ; Cousins, Ryan ; Mullinax, Billy Joe ; Ko, Yi-An ; Little, Kendra ; Smith, Andrew ; Quyyumi, Arshed ; Goyal, Abhinav ; Pearson, Thomas ; Moncayo, Valeria ; Mitchell, Adam J.</creator><creatorcontrib>Godwin, Lehman ; Zheng, Ziduo ; Kundu, Suprateek ; Cousins, Ryan ; Mullinax, Billy Joe ; Ko, Yi-An ; Little, Kendra ; Smith, Andrew ; Quyyumi, Arshed ; Goyal, Abhinav ; Pearson, Thomas ; Moncayo, Valeria ; Mitchell, Adam J.</creatorcontrib><description>The optimal coronary artery disease surveillance strategy for end-stage renal disease patients being evaluated for kidney transplantation is unknown. It is unclear what risk factors are associated with the development of new-onset perfusion abnormalities on serial myocardial perfusion imaging. Potential kidney transplant recipients who underwent 2 myocardial perfusion imaging studies at Emory University Hospital between January 2010 and December 2019 were identified. We assessed the frequency of development of any new perfusion defect and development of moderate to severe ischemia (reversible perfusion defect &gt;10%) on serial imaging. Finally, we identified the clinical and imaging factors associated with new perfusion defects and explored the association between new perfusion defects and all-cause mortality. History of myocardial infarction (MI) and peripheral artery disease was associated with an increased risk of developing a new perfusion defect. History of MI was also associated with the risk of developing moderate-severe ischemia. Female patients were less likely to develop new perfusion defects or moderate-severe ischemia. There was no association between either outcome and all-cause mortality. In conclusion, a history of MI, peripheral artery disease, and male gender are risk factors for developing new perfusion defects, although only the history of MI and male gender predict moderate to severe ischemia. Interval development of any abnormal perfusion is not associated with increased mortality.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2022.03.030</identifier><identifier>PMID: 35504743</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abnormalities ; Angina pectoris ; Cardiovascular disease ; Coronary artery ; Coronary artery disease ; Coronary vessels ; Defects ; Diabetes ; Ejection fraction ; End-stage renal disease ; Gender ; Heart diseases ; Hospitals ; Hypertension ; Ischemia ; Kidney diseases ; Kidney transplantation ; Kidney transplants ; Males ; Medical imaging ; Mortality ; Myocardial infarction ; Patients ; Perfusion ; Risk analysis ; Risk factors ; Surveillance ; Tomography ; Vascular diseases ; Vein &amp; artery diseases</subject><ispartof>The American journal of cardiology, 2022-07, Vol.174, p.84-88</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022 Elsevier Inc. All rights reserved.</rights><rights>2022. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c341t-be722419b72f29575bfdce61a05ca42e70ea70bff85ace2362bf506e3c01b48e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002914922003320$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35504743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Godwin, Lehman</creatorcontrib><creatorcontrib>Zheng, Ziduo</creatorcontrib><creatorcontrib>Kundu, Suprateek</creatorcontrib><creatorcontrib>Cousins, Ryan</creatorcontrib><creatorcontrib>Mullinax, Billy Joe</creatorcontrib><creatorcontrib>Ko, Yi-An</creatorcontrib><creatorcontrib>Little, Kendra</creatorcontrib><creatorcontrib>Smith, Andrew</creatorcontrib><creatorcontrib>Quyyumi, Arshed</creatorcontrib><creatorcontrib>Goyal, Abhinav</creatorcontrib><creatorcontrib>Pearson, Thomas</creatorcontrib><creatorcontrib>Moncayo, Valeria</creatorcontrib><creatorcontrib>Mitchell, Adam J.</creatorcontrib><title>Risk Factors Associated With New-Onset Myocardial Perfusion Abnormalities in Kidney Transplant Candidates</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The optimal coronary artery disease surveillance strategy for end-stage renal disease patients being evaluated for kidney transplantation is unknown. It is unclear what risk factors are associated with the development of new-onset perfusion abnormalities on serial myocardial perfusion imaging. Potential kidney transplant recipients who underwent 2 myocardial perfusion imaging studies at Emory University Hospital between January 2010 and December 2019 were identified. We assessed the frequency of development of any new perfusion defect and development of moderate to severe ischemia (reversible perfusion defect &gt;10%) on serial imaging. Finally, we identified the clinical and imaging factors associated with new perfusion defects and explored the association between new perfusion defects and all-cause mortality. History of myocardial infarction (MI) and peripheral artery disease was associated with an increased risk of developing a new perfusion defect. History of MI was also associated with the risk of developing moderate-severe ischemia. Female patients were less likely to develop new perfusion defects or moderate-severe ischemia. There was no association between either outcome and all-cause mortality. In conclusion, a history of MI, peripheral artery disease, and male gender are risk factors for developing new perfusion defects, although only the history of MI and male gender predict moderate to severe ischemia. Interval development of any abnormal perfusion is not associated with increased mortality.</description><subject>Abnormalities</subject><subject>Angina pectoris</subject><subject>Cardiovascular disease</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary vessels</subject><subject>Defects</subject><subject>Diabetes</subject><subject>Ejection fraction</subject><subject>End-stage renal disease</subject><subject>Gender</subject><subject>Heart diseases</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Ischemia</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Kidney transplants</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Surveillance</subject><subject>Tomography</subject><subject>Vascular diseases</subject><subject>Vein &amp; artery diseases</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUGLFDEQhYMo7uzqT1ACXrz0WEk66clJhsF1xdUVWfEY0ulqTNudjEm3Mv_eDDN68CIUFAVfvXrUI-QZgzUDpl4NazsNzqZuzYHzNYhS8ICs2KbRFdNMPCQrAOCVZrW-IJc5D2VkTKrH5EJICXVTixXxn33-Tq-tm2PKdJtzdN7O2NGvfv5GP-Kv6i5knOmHQzwe83aknzD1S_Yx0G0bYprs6GePmfpA3_su4IHeJxvyfrRhpjsbOt8VxfyEPOrtmPHpuV-RL9dv7nc31e3d23e77W3lRM3mqsWG85rptuE917KRbd85VMyCdLbm2ADaBtq-30jrkAvF216CQuGAtfUGxRV5edLdp_hjwTybyWeHY7GDccmGK6kVKNCqoC_-QYe4pFDcFUppyRqhRaHkiXIp5pywN_vkJ5sOhoE5ZmEGc87CHLMwIEpB2Xt-Vl_aCbu_W3-eX4DXJwDLO356TCY7j8Fh5xO62XTR_-fEb2P-nYs</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Godwin, Lehman</creator><creator>Zheng, Ziduo</creator><creator>Kundu, Suprateek</creator><creator>Cousins, Ryan</creator><creator>Mullinax, Billy Joe</creator><creator>Ko, Yi-An</creator><creator>Little, Kendra</creator><creator>Smith, Andrew</creator><creator>Quyyumi, Arshed</creator><creator>Goyal, Abhinav</creator><creator>Pearson, Thomas</creator><creator>Moncayo, Valeria</creator><creator>Mitchell, Adam J.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20220701</creationdate><title>Risk Factors Associated With New-Onset Myocardial Perfusion Abnormalities in Kidney Transplant Candidates</title><author>Godwin, Lehman ; Zheng, Ziduo ; Kundu, Suprateek ; Cousins, Ryan ; Mullinax, Billy Joe ; Ko, Yi-An ; Little, Kendra ; Smith, Andrew ; Quyyumi, Arshed ; Goyal, Abhinav ; Pearson, Thomas ; Moncayo, Valeria ; Mitchell, Adam J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-be722419b72f29575bfdce61a05ca42e70ea70bff85ace2362bf506e3c01b48e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abnormalities</topic><topic>Angina pectoris</topic><topic>Cardiovascular disease</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary vessels</topic><topic>Defects</topic><topic>Diabetes</topic><topic>Ejection fraction</topic><topic>End-stage renal disease</topic><topic>Gender</topic><topic>Heart diseases</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Ischemia</topic><topic>Kidney diseases</topic><topic>Kidney transplantation</topic><topic>Kidney transplants</topic><topic>Males</topic><topic>Medical imaging</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Patients</topic><topic>Perfusion</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Surveillance</topic><topic>Tomography</topic><topic>Vascular diseases</topic><topic>Vein &amp; artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Godwin, Lehman</creatorcontrib><creatorcontrib>Zheng, Ziduo</creatorcontrib><creatorcontrib>Kundu, Suprateek</creatorcontrib><creatorcontrib>Cousins, Ryan</creatorcontrib><creatorcontrib>Mullinax, Billy Joe</creatorcontrib><creatorcontrib>Ko, Yi-An</creatorcontrib><creatorcontrib>Little, Kendra</creatorcontrib><creatorcontrib>Smith, Andrew</creatorcontrib><creatorcontrib>Quyyumi, Arshed</creatorcontrib><creatorcontrib>Goyal, Abhinav</creatorcontrib><creatorcontrib>Pearson, Thomas</creatorcontrib><creatorcontrib>Moncayo, Valeria</creatorcontrib><creatorcontrib>Mitchell, Adam J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Godwin, Lehman</au><au>Zheng, Ziduo</au><au>Kundu, Suprateek</au><au>Cousins, Ryan</au><au>Mullinax, Billy Joe</au><au>Ko, Yi-An</au><au>Little, Kendra</au><au>Smith, Andrew</au><au>Quyyumi, Arshed</au><au>Goyal, Abhinav</au><au>Pearson, Thomas</au><au>Moncayo, Valeria</au><au>Mitchell, Adam J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors Associated With New-Onset Myocardial Perfusion Abnormalities in Kidney Transplant Candidates</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>174</volume><spage>84</spage><epage>88</epage><pages>84-88</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>The optimal coronary artery disease surveillance strategy for end-stage renal disease patients being evaluated for kidney transplantation is unknown. It is unclear what risk factors are associated with the development of new-onset perfusion abnormalities on serial myocardial perfusion imaging. Potential kidney transplant recipients who underwent 2 myocardial perfusion imaging studies at Emory University Hospital between January 2010 and December 2019 were identified. We assessed the frequency of development of any new perfusion defect and development of moderate to severe ischemia (reversible perfusion defect &gt;10%) on serial imaging. Finally, we identified the clinical and imaging factors associated with new perfusion defects and explored the association between new perfusion defects and all-cause mortality. History of myocardial infarction (MI) and peripheral artery disease was associated with an increased risk of developing a new perfusion defect. History of MI was also associated with the risk of developing moderate-severe ischemia. Female patients were less likely to develop new perfusion defects or moderate-severe ischemia. There was no association between either outcome and all-cause mortality. In conclusion, a history of MI, peripheral artery disease, and male gender are risk factors for developing new perfusion defects, although only the history of MI and male gender predict moderate to severe ischemia. Interval development of any abnormal perfusion is not associated with increased mortality.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35504743</pmid><doi>10.1016/j.amjcard.2022.03.030</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0002-9149
ispartof The American journal of cardiology, 2022-07, Vol.174, p.84-88
issn 0002-9149
1879-1913
language eng
recordid cdi_proquest_miscellaneous_2659606096
source Elsevier ScienceDirect Journals
subjects Abnormalities
Angina pectoris
Cardiovascular disease
Coronary artery
Coronary artery disease
Coronary vessels
Defects
Diabetes
Ejection fraction
End-stage renal disease
Gender
Heart diseases
Hospitals
Hypertension
Ischemia
Kidney diseases
Kidney transplantation
Kidney transplants
Males
Medical imaging
Mortality
Myocardial infarction
Patients
Perfusion
Risk analysis
Risk factors
Surveillance
Tomography
Vascular diseases
Vein & artery diseases
title Risk Factors Associated With New-Onset Myocardial Perfusion Abnormalities in Kidney Transplant Candidates
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T00%3A51%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20Factors%20Associated%20With%20New-Onset%20Myocardial%20Perfusion%20Abnormalities%20in%20Kidney%20Transplant%20Candidates&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Godwin,%20Lehman&rft.date=2022-07-01&rft.volume=174&rft.spage=84&rft.epage=88&rft.pages=84-88&rft.issn=0002-9149&rft.eissn=1879-1913&rft_id=info:doi/10.1016/j.amjcard.2022.03.030&rft_dat=%3Cproquest_cross%3E2669517393%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2669517393&rft_id=info:pmid/35504743&rft_els_id=S0002914922003320&rfr_iscdi=true