Autologous testicular tunica vaginalis graft in Peyronie’s disease: a prospective evaluation
Background Peyronie’s disease (PD) is a two-phase progressive condition characterized by inelastic plaques in the tunica albuginea of the penis, leading to curvature of the penis. Men with PD also suffer from psychological distress, and sexual life and overall quality of life. Although the preferred...
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| Veröffentlicht in: | International urology and nephrology 2022-07, Vol.54 (7), p.1545-1550 |
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| creator | Ainayev, Yernur Zhanbyrbekuly, Ulanbek Gaipov, Abduzhappar Kissamedenov, Nurlan Zhaparov, Ulan Suleiman, Makhmud Urazova, Saltanat Rakhmetova, Nurila Turebayev, Dulat Keulimzhayev, Nurbol Zhankina, Rano Khairli, Gafur |
| description | Background
Peyronie’s disease (PD) is a two-phase progressive condition characterized by inelastic plaques in the tunica albuginea of the penis, leading to curvature of the penis. Men with PD also suffer from psychological distress, and sexual life and overall quality of life. Although the preferred surgical treatment modality in Peyronie’s disease is plaque incision and grafting, there is lack of studies assessing the erectile function and penile vasculature after the treatment.
Objectives
We aimed to evaluate the efficiency and safety of plaque incision and tunica vaginalis of testis grafting in PD.
Methods
This was a prospective analysis. Erectile dysfunction was assessed via International Index of Erectile Function Questionnaire (IIEF-5). Penile Doppler ultrasound was performed to assess peak systolic velocity (PSV) and end-diastolic velocity (EDV). Postoperative follow-ups were scheduled at 3, 12, and 24 months.
Results
Twenty patients (mean age 47.2 ± 10.8 years) were included. The mean preoperative penile curvature was 48 ± 6.6°. The technical success rate was 100% at 3 months and 90% at 24 months. At follow-up visits, mean erect penile length was no different from the baseline. The baseline mean IIEF-5 score was 18.4 ± 2.5. The mean IIEF-5 score was 20.6 ± 2.6 at 24-month visit (
p
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| doi_str_mv | 10.1007/s11255-022-03223-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2659230642</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2674564601</sourcerecordid><originalsourceid>FETCH-LOGICAL-c338t-e4a1352de8c7cef2218868989bdea42c1314da42ae0ac8a04722fb48177dd133</originalsourceid><addsrcrecordid>eNp9kM1OGzEURi1UVNK0L8CistRNN1Ou_2YcdhGiUCkSLFhj3XjuREaTmdSeicSO1-jr8SR1CIWKBStfycef73cYOxbwQwBUJ0kIaUwBUhagpFSFOmATYSpVSGP1h__mI_YppTsAmFmAj-xIGQNKg5iw2_k49G2_6sfEB0pD8GOLkQ9jFzzyLa5Ch21IfBWxGXjo-DXdx74L9PjwJ_E6JMJEpxz5JvZpQ34IW-K0xXbEIfTdZ3bYYJvoy_M5ZTc_z2_OLovF1cWvs_mi8ErZoSCNQhlZk_WVp0ZKYW1pZ3a2rAm19EIJXecBCdBbBF1J2Sy1FVVV10KpKfu-j81b_B5zDbcOyVPbYke5mZOlmUkFpZYZ_fYGvevHmEvuqEqbUpcgMiX3lM-1UqTGbWJYY7x3AtxOvtvLd1m-e5Lvdlt8fY4el2uqX578s50BtQdSvupWFF__fif2Ly_bkLg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2674564601</pqid></control><display><type>article</type><title>Autologous testicular tunica vaginalis graft in Peyronie’s disease: a prospective evaluation</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Ainayev, Yernur ; Zhanbyrbekuly, Ulanbek ; Gaipov, Abduzhappar ; Kissamedenov, Nurlan ; Zhaparov, Ulan ; Suleiman, Makhmud ; Urazova, Saltanat ; Rakhmetova, Nurila ; Turebayev, Dulat ; Keulimzhayev, Nurbol ; Zhankina, Rano ; Khairli, Gafur</creator><creatorcontrib>Ainayev, Yernur ; Zhanbyrbekuly, Ulanbek ; Gaipov, Abduzhappar ; Kissamedenov, Nurlan ; Zhaparov, Ulan ; Suleiman, Makhmud ; Urazova, Saltanat ; Rakhmetova, Nurila ; Turebayev, Dulat ; Keulimzhayev, Nurbol ; Zhankina, Rano ; Khairli, Gafur</creatorcontrib><description>Background
Peyronie’s disease (PD) is a two-phase progressive condition characterized by inelastic plaques in the tunica albuginea of the penis, leading to curvature of the penis. Men with PD also suffer from psychological distress, and sexual life and overall quality of life. Although the preferred surgical treatment modality in Peyronie’s disease is plaque incision and grafting, there is lack of studies assessing the erectile function and penile vasculature after the treatment.
Objectives
We aimed to evaluate the efficiency and safety of plaque incision and tunica vaginalis of testis grafting in PD.
Methods
This was a prospective analysis. Erectile dysfunction was assessed via International Index of Erectile Function Questionnaire (IIEF-5). Penile Doppler ultrasound was performed to assess peak systolic velocity (PSV) and end-diastolic velocity (EDV). Postoperative follow-ups were scheduled at 3, 12, and 24 months.
Results
Twenty patients (mean age 47.2 ± 10.8 years) were included. The mean preoperative penile curvature was 48 ± 6.6°. The technical success rate was 100% at 3 months and 90% at 24 months. At follow-up visits, mean erect penile length was no different from the baseline. The baseline mean IIEF-5 score was 18.4 ± 2.5. The mean IIEF-5 score was 20.6 ± 2.6 at 24-month visit (
p
< 0.0001). Mean PSV significantly increased, while EDV significantly reduced after surgery. There were no serious complications related to surgery.
Conclusions
We conclude that surgical reconstruction of penile curvature with tunica vaginalis grafting was a safe and effective procedure in PD.</description><identifier>ISSN: 1573-2584</identifier><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-022-03223-3</identifier><identifier>PMID: 35503401</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Autografts ; Connective tissue diseases ; Doppler effect ; Erectile dysfunction ; Erectile Dysfunction - etiology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Patient Satisfaction ; Penile Induration - complications ; Penile Induration - surgery ; Penis ; Penis - surgery ; Plaques ; Quality of Life ; Reconstructive surgery ; Testis - diagnostic imaging ; Testis - surgery ; Treatment Outcome ; Urology ; Urology - Original Paper ; Velocity</subject><ispartof>International urology and nephrology, 2022-07, Vol.54 (7), p.1545-1550</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-e4a1352de8c7cef2218868989bdea42c1314da42ae0ac8a04722fb48177dd133</citedby><cites>FETCH-LOGICAL-c338t-e4a1352de8c7cef2218868989bdea42c1314da42ae0ac8a04722fb48177dd133</cites><orcidid>0000-0003-3673-5730</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-022-03223-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-022-03223-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35503401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ainayev, Yernur</creatorcontrib><creatorcontrib>Zhanbyrbekuly, Ulanbek</creatorcontrib><creatorcontrib>Gaipov, Abduzhappar</creatorcontrib><creatorcontrib>Kissamedenov, Nurlan</creatorcontrib><creatorcontrib>Zhaparov, Ulan</creatorcontrib><creatorcontrib>Suleiman, Makhmud</creatorcontrib><creatorcontrib>Urazova, Saltanat</creatorcontrib><creatorcontrib>Rakhmetova, Nurila</creatorcontrib><creatorcontrib>Turebayev, Dulat</creatorcontrib><creatorcontrib>Keulimzhayev, Nurbol</creatorcontrib><creatorcontrib>Zhankina, Rano</creatorcontrib><creatorcontrib>Khairli, Gafur</creatorcontrib><title>Autologous testicular tunica vaginalis graft in Peyronie’s disease: a prospective evaluation</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Background
Peyronie’s disease (PD) is a two-phase progressive condition characterized by inelastic plaques in the tunica albuginea of the penis, leading to curvature of the penis. Men with PD also suffer from psychological distress, and sexual life and overall quality of life. Although the preferred surgical treatment modality in Peyronie’s disease is plaque incision and grafting, there is lack of studies assessing the erectile function and penile vasculature after the treatment.
Objectives
We aimed to evaluate the efficiency and safety of plaque incision and tunica vaginalis of testis grafting in PD.
Methods
This was a prospective analysis. Erectile dysfunction was assessed via International Index of Erectile Function Questionnaire (IIEF-5). Penile Doppler ultrasound was performed to assess peak systolic velocity (PSV) and end-diastolic velocity (EDV). Postoperative follow-ups were scheduled at 3, 12, and 24 months.
Results
Twenty patients (mean age 47.2 ± 10.8 years) were included. The mean preoperative penile curvature was 48 ± 6.6°. The technical success rate was 100% at 3 months and 90% at 24 months. At follow-up visits, mean erect penile length was no different from the baseline. The baseline mean IIEF-5 score was 18.4 ± 2.5. The mean IIEF-5 score was 20.6 ± 2.6 at 24-month visit (
p
< 0.0001). Mean PSV significantly increased, while EDV significantly reduced after surgery. There were no serious complications related to surgery.
Conclusions
We conclude that surgical reconstruction of penile curvature with tunica vaginalis grafting was a safe and effective procedure in PD.</description><subject>Adult</subject><subject>Autografts</subject><subject>Connective tissue diseases</subject><subject>Doppler effect</subject><subject>Erectile dysfunction</subject><subject>Erectile Dysfunction - etiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Patient Satisfaction</subject><subject>Penile Induration - complications</subject><subject>Penile Induration - surgery</subject><subject>Penis</subject><subject>Penis - surgery</subject><subject>Plaques</subject><subject>Quality of Life</subject><subject>Reconstructive surgery</subject><subject>Testis - diagnostic imaging</subject><subject>Testis - surgery</subject><subject>Treatment Outcome</subject><subject>Urology</subject><subject>Urology - Original Paper</subject><subject>Velocity</subject><issn>1573-2584</issn><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kM1OGzEURi1UVNK0L8CistRNN1Ou_2YcdhGiUCkSLFhj3XjuREaTmdSeicSO1-jr8SR1CIWKBStfycef73cYOxbwQwBUJ0kIaUwBUhagpFSFOmATYSpVSGP1h__mI_YppTsAmFmAj-xIGQNKg5iw2_k49G2_6sfEB0pD8GOLkQ9jFzzyLa5Ch21IfBWxGXjo-DXdx74L9PjwJ_E6JMJEpxz5JvZpQ34IW-K0xXbEIfTdZ3bYYJvoy_M5ZTc_z2_OLovF1cWvs_mi8ErZoSCNQhlZk_WVp0ZKYW1pZ3a2rAm19EIJXecBCdBbBF1J2Sy1FVVV10KpKfu-j81b_B5zDbcOyVPbYke5mZOlmUkFpZYZ_fYGvevHmEvuqEqbUpcgMiX3lM-1UqTGbWJYY7x3AtxOvtvLd1m-e5Lvdlt8fY4el2uqX578s50BtQdSvupWFF__fif2Ly_bkLg</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Ainayev, Yernur</creator><creator>Zhanbyrbekuly, Ulanbek</creator><creator>Gaipov, Abduzhappar</creator><creator>Kissamedenov, Nurlan</creator><creator>Zhaparov, Ulan</creator><creator>Suleiman, Makhmud</creator><creator>Urazova, Saltanat</creator><creator>Rakhmetova, Nurila</creator><creator>Turebayev, Dulat</creator><creator>Keulimzhayev, Nurbol</creator><creator>Zhankina, Rano</creator><creator>Khairli, Gafur</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3673-5730</orcidid></search><sort><creationdate>20220701</creationdate><title>Autologous testicular tunica vaginalis graft in Peyronie’s disease: a prospective evaluation</title><author>Ainayev, Yernur ; Zhanbyrbekuly, Ulanbek ; Gaipov, Abduzhappar ; Kissamedenov, Nurlan ; Zhaparov, Ulan ; Suleiman, Makhmud ; Urazova, Saltanat ; Rakhmetova, Nurila ; Turebayev, Dulat ; Keulimzhayev, Nurbol ; Zhankina, Rano ; Khairli, Gafur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-e4a1352de8c7cef2218868989bdea42c1314da42ae0ac8a04722fb48177dd133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Autografts</topic><topic>Connective tissue diseases</topic><topic>Doppler effect</topic><topic>Erectile dysfunction</topic><topic>Erectile Dysfunction - etiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Patient Satisfaction</topic><topic>Penile Induration - complications</topic><topic>Penile Induration - surgery</topic><topic>Penis</topic><topic>Penis - surgery</topic><topic>Plaques</topic><topic>Quality of Life</topic><topic>Reconstructive surgery</topic><topic>Testis - diagnostic imaging</topic><topic>Testis - surgery</topic><topic>Treatment Outcome</topic><topic>Urology</topic><topic>Urology - Original Paper</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ainayev, Yernur</creatorcontrib><creatorcontrib>Zhanbyrbekuly, Ulanbek</creatorcontrib><creatorcontrib>Gaipov, Abduzhappar</creatorcontrib><creatorcontrib>Kissamedenov, Nurlan</creatorcontrib><creatorcontrib>Zhaparov, Ulan</creatorcontrib><creatorcontrib>Suleiman, Makhmud</creatorcontrib><creatorcontrib>Urazova, Saltanat</creatorcontrib><creatorcontrib>Rakhmetova, Nurila</creatorcontrib><creatorcontrib>Turebayev, Dulat</creatorcontrib><creatorcontrib>Keulimzhayev, Nurbol</creatorcontrib><creatorcontrib>Zhankina, Rano</creatorcontrib><creatorcontrib>Khairli, Gafur</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ainayev, Yernur</au><au>Zhanbyrbekuly, Ulanbek</au><au>Gaipov, Abduzhappar</au><au>Kissamedenov, Nurlan</au><au>Zhaparov, Ulan</au><au>Suleiman, Makhmud</au><au>Urazova, Saltanat</au><au>Rakhmetova, Nurila</au><au>Turebayev, Dulat</au><au>Keulimzhayev, Nurbol</au><au>Zhankina, Rano</au><au>Khairli, Gafur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autologous testicular tunica vaginalis graft in Peyronie’s disease: a prospective evaluation</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>54</volume><issue>7</issue><spage>1545</spage><epage>1550</epage><pages>1545-1550</pages><issn>1573-2584</issn><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract>Background
Peyronie’s disease (PD) is a two-phase progressive condition characterized by inelastic plaques in the tunica albuginea of the penis, leading to curvature of the penis. Men with PD also suffer from psychological distress, and sexual life and overall quality of life. Although the preferred surgical treatment modality in Peyronie’s disease is plaque incision and grafting, there is lack of studies assessing the erectile function and penile vasculature after the treatment.
Objectives
We aimed to evaluate the efficiency and safety of plaque incision and tunica vaginalis of testis grafting in PD.
Methods
This was a prospective analysis. Erectile dysfunction was assessed via International Index of Erectile Function Questionnaire (IIEF-5). Penile Doppler ultrasound was performed to assess peak systolic velocity (PSV) and end-diastolic velocity (EDV). Postoperative follow-ups were scheduled at 3, 12, and 24 months.
Results
Twenty patients (mean age 47.2 ± 10.8 years) were included. The mean preoperative penile curvature was 48 ± 6.6°. The technical success rate was 100% at 3 months and 90% at 24 months. At follow-up visits, mean erect penile length was no different from the baseline. The baseline mean IIEF-5 score was 18.4 ± 2.5. The mean IIEF-5 score was 20.6 ± 2.6 at 24-month visit (
p
< 0.0001). Mean PSV significantly increased, while EDV significantly reduced after surgery. There were no serious complications related to surgery.
Conclusions
We conclude that surgical reconstruction of penile curvature with tunica vaginalis grafting was a safe and effective procedure in PD.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>35503401</pmid><doi>10.1007/s11255-022-03223-3</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3673-5730</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1573-2584 |
| ispartof | International urology and nephrology, 2022-07, Vol.54 (7), p.1545-1550 |
| issn | 1573-2584 0301-1623 1573-2584 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Autografts Connective tissue diseases Doppler effect Erectile dysfunction Erectile Dysfunction - etiology Humans Male Medicine Medicine & Public Health Middle Aged Nephrology Patient Satisfaction Penile Induration - complications Penile Induration - surgery Penis Penis - surgery Plaques Quality of Life Reconstructive surgery Testis - diagnostic imaging Testis - surgery Treatment Outcome Urology Urology - Original Paper Velocity |
| title | Autologous testicular tunica vaginalis graft in Peyronie’s disease: a prospective evaluation |
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