Predictive Value of Resting Fractional Flow Reserve and Atherogenic Index of Plasma for Evaluation of Physiologically Significant Coronary Artery Lesions
This study aimed to assess the relationship between the atherogenic index of plasma (AIP) and resting distal-to-aortic pressure ratio (Pd/Pa) in patients with intermediate coronary artery stenosis. This retrospective study included 802 chronic coronary syndrome patients with intermediate coronary ar...
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| Veröffentlicht in: | Angiology 2023-03, Vol.74 (3), p.282-287 |
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| creator | BALCI, Mustafa M. BALCI, Kevser G. OCAK, Kadir EKİCİ, Ertan ÇETİN, Elif H. SELÇUK, Hatice SELÇUK, Timur MADEN, Orhan |
| description | This study aimed to assess the relationship between the atherogenic index of plasma (AIP) and resting distal-to-aortic pressure ratio (Pd/Pa) in patients with intermediate coronary artery stenosis. This retrospective study included 802 chronic coronary syndrome patients with intermediate coronary artery stenosis who underwent fractional flow reserve (FFR) measurement. The resting Pd/Pa showed a significant negative correlation with AIP (rho= −.205, p < .001). When final FFR was divided into three tertiles (≤80, 81–89, ≥90), resting Pd/Pa was significantly lower, and AIP was markedly higher in the lower final FFR tertiles (both AIP and resting Pd/Pa differed significantly across the all three tertiles, p < .001). Furthermore, functionally significant stenosis independent predictors in multivariate analyses were AIP and resting Pd/Pa (p = .010 and p < .001, respectively). We observed for the first time an increase in AIP levels in the presence of functionally significant stenoses that may help better planning and identification of those patients with the functionally substantial atherosclerotic burden. |
| doi_str_mv | 10.1177/00033197221098280 |
| format | Article |
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This retrospective study included 802 chronic coronary syndrome patients with intermediate coronary artery stenosis who underwent fractional flow reserve (FFR) measurement. The resting Pd/Pa showed a significant negative correlation with AIP (rho= −.205, p < .001). When final FFR was divided into three tertiles (≤80, 81–89, ≥90), resting Pd/Pa was significantly lower, and AIP was markedly higher in the lower final FFR tertiles (both AIP and resting Pd/Pa differed significantly across the all three tertiles, p < .001). Furthermore, functionally significant stenosis independent predictors in multivariate analyses were AIP and resting Pd/Pa (p = .010 and p < .001, respectively). We observed for the first time an increase in AIP levels in the presence of functionally significant stenoses that may help better planning and identification of those patients with the functionally substantial atherosclerotic burden.</description><identifier>ISSN: 0003-3197</identifier><identifier>EISSN: 1940-1574</identifier><identifier>DOI: 10.1177/00033197221098280</identifier><identifier>PMID: 35500241</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Cardiac Catheterization ; Coronary Angiography ; Coronary Stenosis - diagnosis ; Coronary Vessels ; Fractional Flow Reserve, Myocardial - physiology ; Humans ; Hyperemia ; Predictive Value of Tests ; Retrospective Studies ; Severity of Illness Index</subject><ispartof>Angiology, 2023-03, Vol.74 (3), p.282-287</ispartof><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c270t-b1ad686141bf759eac32d4a111183301404e9016c75cdb1d196d40a8a3453d603</citedby><cites>FETCH-LOGICAL-c270t-b1ad686141bf759eac32d4a111183301404e9016c75cdb1d196d40a8a3453d603</cites><orcidid>0000-0001-5969-2345 ; 0000-0002-2311-1825 ; 0000-0002-8427-6631</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/00033197221098280$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/00033197221098280$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35500241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BALCI, Mustafa M.</creatorcontrib><creatorcontrib>BALCI, Kevser G.</creatorcontrib><creatorcontrib>OCAK, Kadir</creatorcontrib><creatorcontrib>EKİCİ, Ertan</creatorcontrib><creatorcontrib>ÇETİN, Elif H.</creatorcontrib><creatorcontrib>SELÇUK, Hatice</creatorcontrib><creatorcontrib>SELÇUK, Timur</creatorcontrib><creatorcontrib>MADEN, Orhan</creatorcontrib><title>Predictive Value of Resting Fractional Flow Reserve and Atherogenic Index of Plasma for Evaluation of Physiologically Significant Coronary Artery Lesions</title><title>Angiology</title><addtitle>Angiology</addtitle><description>This study aimed to assess the relationship between the atherogenic index of plasma (AIP) and resting distal-to-aortic pressure ratio (Pd/Pa) in patients with intermediate coronary artery stenosis. This retrospective study included 802 chronic coronary syndrome patients with intermediate coronary artery stenosis who underwent fractional flow reserve (FFR) measurement. The resting Pd/Pa showed a significant negative correlation with AIP (rho= −.205, p < .001). When final FFR was divided into three tertiles (≤80, 81–89, ≥90), resting Pd/Pa was significantly lower, and AIP was markedly higher in the lower final FFR tertiles (both AIP and resting Pd/Pa differed significantly across the all three tertiles, p < .001). Furthermore, functionally significant stenosis independent predictors in multivariate analyses were AIP and resting Pd/Pa (p = .010 and p < .001, respectively). We observed for the first time an increase in AIP levels in the presence of functionally significant stenoses that may help better planning and identification of those patients with the functionally substantial atherosclerotic burden.</description><subject>Cardiac Catheterization</subject><subject>Coronary Angiography</subject><subject>Coronary Stenosis - diagnosis</subject><subject>Coronary Vessels</subject><subject>Fractional Flow Reserve, Myocardial - physiology</subject><subject>Humans</subject><subject>Hyperemia</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><issn>0003-3197</issn><issn>1940-1574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctuFDEQRS0EIkPgA9ggL9l0qGq7X8vRKAORRiLitW157OqOI48d7O6E-RT-FjcT2CDhTal8z71-FGOvES4Qm-YdAAiBXVOWCF1btvCErbCTUGDVyKdstejFApyxFynd5rZCqJ-zM1FVAKXEFft5HclYPdl74t-Um4mHgX-iNFk_8m1UWQleOb514WHZp5hB5Q1fTzcUw0jean7lDf1YjNdOpYPiQ4j88j6nqcX9W7g5JhtcGK1Wzh35Zzt6O-TGT3wTYj4iHvk6TpTLjjLq00v2bFAu0avHes6-bi-_bD4Uu4_vrzbrXaHLBqZij8rUbY0S90NTdaS0KI1UmFcrBKAESR1grZtKmz0a7GojQbVKyEqYGsQ5e3vKvYvh-5xf3h9s0uSc8hTm1Jd11ZUCpBAZxROqY0gp0tDfRXvIV-8R-mUi_T8TyZ43j_Hz_kDmr-PPCDJwcQKSGqm_DXPM_53-k_gLPz2Ugg</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>BALCI, Mustafa M.</creator><creator>BALCI, Kevser G.</creator><creator>OCAK, Kadir</creator><creator>EKİCİ, Ertan</creator><creator>ÇETİN, Elif H.</creator><creator>SELÇUK, Hatice</creator><creator>SELÇUK, Timur</creator><creator>MADEN, Orhan</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5969-2345</orcidid><orcidid>https://orcid.org/0000-0002-2311-1825</orcidid><orcidid>https://orcid.org/0000-0002-8427-6631</orcidid></search><sort><creationdate>202303</creationdate><title>Predictive Value of Resting Fractional Flow Reserve and Atherogenic Index of Plasma for Evaluation of Physiologically Significant Coronary Artery Lesions</title><author>BALCI, Mustafa M. ; BALCI, Kevser G. ; OCAK, Kadir ; EKİCİ, Ertan ; ÇETİN, Elif H. ; SELÇUK, Hatice ; SELÇUK, Timur ; MADEN, Orhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-b1ad686141bf759eac32d4a111183301404e9016c75cdb1d196d40a8a3453d603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiac Catheterization</topic><topic>Coronary Angiography</topic><topic>Coronary Stenosis - diagnosis</topic><topic>Coronary Vessels</topic><topic>Fractional Flow Reserve, Myocardial - physiology</topic><topic>Humans</topic><topic>Hyperemia</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BALCI, Mustafa M.</creatorcontrib><creatorcontrib>BALCI, Kevser G.</creatorcontrib><creatorcontrib>OCAK, Kadir</creatorcontrib><creatorcontrib>EKİCİ, Ertan</creatorcontrib><creatorcontrib>ÇETİN, Elif H.</creatorcontrib><creatorcontrib>SELÇUK, Hatice</creatorcontrib><creatorcontrib>SELÇUK, Timur</creatorcontrib><creatorcontrib>MADEN, Orhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Angiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BALCI, Mustafa M.</au><au>BALCI, Kevser G.</au><au>OCAK, Kadir</au><au>EKİCİ, Ertan</au><au>ÇETİN, Elif H.</au><au>SELÇUK, Hatice</au><au>SELÇUK, Timur</au><au>MADEN, Orhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Value of Resting Fractional Flow Reserve and Atherogenic Index of Plasma for Evaluation of Physiologically Significant Coronary Artery Lesions</atitle><jtitle>Angiology</jtitle><addtitle>Angiology</addtitle><date>2023-03</date><risdate>2023</risdate><volume>74</volume><issue>3</issue><spage>282</spage><epage>287</epage><pages>282-287</pages><issn>0003-3197</issn><eissn>1940-1574</eissn><abstract>This study aimed to assess the relationship between the atherogenic index of plasma (AIP) and resting distal-to-aortic pressure ratio (Pd/Pa) in patients with intermediate coronary artery stenosis. This retrospective study included 802 chronic coronary syndrome patients with intermediate coronary artery stenosis who underwent fractional flow reserve (FFR) measurement. The resting Pd/Pa showed a significant negative correlation with AIP (rho= −.205, p < .001). When final FFR was divided into three tertiles (≤80, 81–89, ≥90), resting Pd/Pa was significantly lower, and AIP was markedly higher in the lower final FFR tertiles (both AIP and resting Pd/Pa differed significantly across the all three tertiles, p < .001). Furthermore, functionally significant stenosis independent predictors in multivariate analyses were AIP and resting Pd/Pa (p = .010 and p < .001, respectively). We observed for the first time an increase in AIP levels in the presence of functionally significant stenoses that may help better planning and identification of those patients with the functionally substantial atherosclerotic burden.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>35500241</pmid><doi>10.1177/00033197221098280</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5969-2345</orcidid><orcidid>https://orcid.org/0000-0002-2311-1825</orcidid><orcidid>https://orcid.org/0000-0002-8427-6631</orcidid></addata></record> |
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| subjects | Cardiac Catheterization Coronary Angiography Coronary Stenosis - diagnosis Coronary Vessels Fractional Flow Reserve, Myocardial - physiology Humans Hyperemia Predictive Value of Tests Retrospective Studies Severity of Illness Index |
| title | Predictive Value of Resting Fractional Flow Reserve and Atherogenic Index of Plasma for Evaluation of Physiologically Significant Coronary Artery Lesions |
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