Salivary biomarkers of oxidative stress in children with dental caries: Systematic review and meta-analysis
To assess the relationship between salivary biomarkers of oxidative stress and dental caries in children. Studies conducted in children up to 12 years old comparing salivary biomarkers of oxidative stress such as malondialdehyde (MDA), superoxide dismutase (SOD), uric acid, and total antioxidant cap...
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| Veröffentlicht in: | Archives of oral biology 2022-07, Vol.139, p.105432-105432, Article 105432 |
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| container_title | Archives of oral biology |
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| creator | Martins, Jordana Resende Díaz-Fabregat, Beatriz Ramírez-Carmona, Wilmer Monteiro, Douglas Roberto Pessan, Juliano Pelim Antoniali, Cristina |
| description | To assess the relationship between salivary biomarkers of oxidative stress and dental caries in children.
Studies conducted in children up to 12 years old comparing salivary biomarkers of oxidative stress such as malondialdehyde (MDA), superoxide dismutase (SOD), uric acid, and total antioxidant capacity (TAC), considering children with dental caries lesions and caries-free ones were selected. In addition, salivary parameters such as salivary flow, pH, buffering capacity, calcium and total protein levels were evaluated. A systematic literature review was carried out in 8 databases. The standardized mean difference (SMD) was measured using inverse variance as a statistical method and random effects as an analysis model, corresponding to a 95% confidence interval (CI).
The TAC levels were higher in children affected by dental caries compared to caries-free ones (control group), regardless of age (SMD 2.66, CI 1.33, 3.98), or gender (SMD 0.98, CI 0.56, 1.39). When adjusted for normalized protein, MDA levels were lower in the dental caries group than in the control group (SMD −16.51, CI −29.02, −4.00), and SOD levels were higher in the dental caries group (SMD 5.09, CI 0.01.10.18). The total protein concentration in saliva of children with dental caries was higher than in the control group, regardless of age (SMD 0.98, CI 0.27, 1.69), or gender (SMD 0.77, CI 0.45, 1.10). The salivary parameters assessed had lower levels in children affected by dental caries (p |
| doi_str_mv | 10.1016/j.archoralbio.2022.105432 |
| format | Article |
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Studies conducted in children up to 12 years old comparing salivary biomarkers of oxidative stress such as malondialdehyde (MDA), superoxide dismutase (SOD), uric acid, and total antioxidant capacity (TAC), considering children with dental caries lesions and caries-free ones were selected. In addition, salivary parameters such as salivary flow, pH, buffering capacity, calcium and total protein levels were evaluated. A systematic literature review was carried out in 8 databases. The standardized mean difference (SMD) was measured using inverse variance as a statistical method and random effects as an analysis model, corresponding to a 95% confidence interval (CI).
The TAC levels were higher in children affected by dental caries compared to caries-free ones (control group), regardless of age (SMD 2.66, CI 1.33, 3.98), or gender (SMD 0.98, CI 0.56, 1.39). When adjusted for normalized protein, MDA levels were lower in the dental caries group than in the control group (SMD −16.51, CI −29.02, −4.00), and SOD levels were higher in the dental caries group (SMD 5.09, CI 0.01.10.18). The total protein concentration in saliva of children with dental caries was higher than in the control group, regardless of age (SMD 0.98, CI 0.27, 1.69), or gender (SMD 0.77, CI 0.45, 1.10). The salivary parameters assessed had lower levels in children affected by dental caries (p < 0.05).
The levels of oxidative stress biomarkers and salivary parameters are altered in saliva of children with dental caries.
•Biomarkers of salivary oxidative stress are influenced by dental caries.•Antioxidant systems are increased in children affected by dental caries.•Biomarkers of oxidative damage are reduced in saliva of children with dental caries.•Salivary parameters are reduced in children with caries lesions.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2022.105432</identifier><identifier>PMID: 35500456</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antioxidants - metabolism ; Biomarker ; Biomarkers - metabolism ; Child ; Dental caries ; Dental Caries - metabolism ; Humans ; Oxidative damage ; Oxidative Stress ; Saliva ; Saliva - chemistry ; Salivary proteins and peptides ; Superoxide Dismutase - metabolism</subject><ispartof>Archives of oral biology, 2022-07, Vol.139, p.105432-105432, Article 105432</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-69b63640d66e3a4939dc4f5a338c075db3c6a1af0da24f185320413d33ebfe8d3</citedby><cites>FETCH-LOGICAL-c377t-69b63640d66e3a4939dc4f5a338c075db3c6a1af0da24f185320413d33ebfe8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archoralbio.2022.105432$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35500456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martins, Jordana Resende</creatorcontrib><creatorcontrib>Díaz-Fabregat, Beatriz</creatorcontrib><creatorcontrib>Ramírez-Carmona, Wilmer</creatorcontrib><creatorcontrib>Monteiro, Douglas Roberto</creatorcontrib><creatorcontrib>Pessan, Juliano Pelim</creatorcontrib><creatorcontrib>Antoniali, Cristina</creatorcontrib><title>Salivary biomarkers of oxidative stress in children with dental caries: Systematic review and meta-analysis</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>To assess the relationship between salivary biomarkers of oxidative stress and dental caries in children.
Studies conducted in children up to 12 years old comparing salivary biomarkers of oxidative stress such as malondialdehyde (MDA), superoxide dismutase (SOD), uric acid, and total antioxidant capacity (TAC), considering children with dental caries lesions and caries-free ones were selected. In addition, salivary parameters such as salivary flow, pH, buffering capacity, calcium and total protein levels were evaluated. A systematic literature review was carried out in 8 databases. The standardized mean difference (SMD) was measured using inverse variance as a statistical method and random effects as an analysis model, corresponding to a 95% confidence interval (CI).
The TAC levels were higher in children affected by dental caries compared to caries-free ones (control group), regardless of age (SMD 2.66, CI 1.33, 3.98), or gender (SMD 0.98, CI 0.56, 1.39). When adjusted for normalized protein, MDA levels were lower in the dental caries group than in the control group (SMD −16.51, CI −29.02, −4.00), and SOD levels were higher in the dental caries group (SMD 5.09, CI 0.01.10.18). The total protein concentration in saliva of children with dental caries was higher than in the control group, regardless of age (SMD 0.98, CI 0.27, 1.69), or gender (SMD 0.77, CI 0.45, 1.10). The salivary parameters assessed had lower levels in children affected by dental caries (p < 0.05).
The levels of oxidative stress biomarkers and salivary parameters are altered in saliva of children with dental caries.
•Biomarkers of salivary oxidative stress are influenced by dental caries.•Antioxidant systems are increased in children affected by dental caries.•Biomarkers of oxidative damage are reduced in saliva of children with dental caries.•Salivary parameters are reduced in children with caries lesions.</description><subject>Antioxidants - metabolism</subject><subject>Biomarker</subject><subject>Biomarkers - metabolism</subject><subject>Child</subject><subject>Dental caries</subject><subject>Dental Caries - metabolism</subject><subject>Humans</subject><subject>Oxidative damage</subject><subject>Oxidative Stress</subject><subject>Saliva</subject><subject>Saliva - chemistry</subject><subject>Salivary proteins and peptides</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PGzEQhq2KqgTav1C5Ny4b7J21N-4NRW1BQuqB9mzN2rOKw35Q2wnk39cotOLIaTSj90PzMPZFiqUUUl9ulxjdZo44dGFe1qKuy101UL9jC7lqTSWV0CdsIYSAyhhtTtlZStuyKq3lB3YKSgnRKL1g93c4hD3GAy9RI8Z7ionPPZ-fgscc9sRTjpQSDxN3mzD4SBN_DHnDPU0ZB-4wBkpf-d0hZRqLxfFI-0CPHCfPR8pY4YTDIYX0kb3vcUj06WWes9_fv_1aX1e3P3_crK9uKwdtmyttOg26EV5rAmwMGO-aXiHAyolW-Q6cRom98Fg3vVwpqEUjwQNQ19PKwzm7OOY-xPnPjlK2Y0iOhgEnmnfJ1lqZGoSEtkjNUerinFKk3j7EUDAcrBT2mbXd2les7TNre2RdvJ9fanbdSP6_8x_cIlgfBVSeLUiiTS7Q5MiHSC5bP4c31PwFIqCXmg</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Martins, Jordana Resende</creator><creator>Díaz-Fabregat, Beatriz</creator><creator>Ramírez-Carmona, Wilmer</creator><creator>Monteiro, Douglas Roberto</creator><creator>Pessan, Juliano Pelim</creator><creator>Antoniali, Cristina</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202207</creationdate><title>Salivary biomarkers of oxidative stress in children with dental caries: Systematic review and meta-analysis</title><author>Martins, Jordana Resende ; Díaz-Fabregat, Beatriz ; Ramírez-Carmona, Wilmer ; Monteiro, Douglas Roberto ; Pessan, Juliano Pelim ; Antoniali, Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-69b63640d66e3a4939dc4f5a338c075db3c6a1af0da24f185320413d33ebfe8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antioxidants - metabolism</topic><topic>Biomarker</topic><topic>Biomarkers - metabolism</topic><topic>Child</topic><topic>Dental caries</topic><topic>Dental Caries - metabolism</topic><topic>Humans</topic><topic>Oxidative damage</topic><topic>Oxidative Stress</topic><topic>Saliva</topic><topic>Saliva - chemistry</topic><topic>Salivary proteins and peptides</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martins, Jordana Resende</creatorcontrib><creatorcontrib>Díaz-Fabregat, Beatriz</creatorcontrib><creatorcontrib>Ramírez-Carmona, Wilmer</creatorcontrib><creatorcontrib>Monteiro, Douglas Roberto</creatorcontrib><creatorcontrib>Pessan, Juliano Pelim</creatorcontrib><creatorcontrib>Antoniali, Cristina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martins, Jordana Resende</au><au>Díaz-Fabregat, Beatriz</au><au>Ramírez-Carmona, Wilmer</au><au>Monteiro, Douglas Roberto</au><au>Pessan, Juliano Pelim</au><au>Antoniali, Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salivary biomarkers of oxidative stress in children with dental caries: Systematic review and meta-analysis</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2022-07</date><risdate>2022</risdate><volume>139</volume><spage>105432</spage><epage>105432</epage><pages>105432-105432</pages><artnum>105432</artnum><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>To assess the relationship between salivary biomarkers of oxidative stress and dental caries in children.
Studies conducted in children up to 12 years old comparing salivary biomarkers of oxidative stress such as malondialdehyde (MDA), superoxide dismutase (SOD), uric acid, and total antioxidant capacity (TAC), considering children with dental caries lesions and caries-free ones were selected. In addition, salivary parameters such as salivary flow, pH, buffering capacity, calcium and total protein levels were evaluated. A systematic literature review was carried out in 8 databases. The standardized mean difference (SMD) was measured using inverse variance as a statistical method and random effects as an analysis model, corresponding to a 95% confidence interval (CI).
The TAC levels were higher in children affected by dental caries compared to caries-free ones (control group), regardless of age (SMD 2.66, CI 1.33, 3.98), or gender (SMD 0.98, CI 0.56, 1.39). When adjusted for normalized protein, MDA levels were lower in the dental caries group than in the control group (SMD −16.51, CI −29.02, −4.00), and SOD levels were higher in the dental caries group (SMD 5.09, CI 0.01.10.18). The total protein concentration in saliva of children with dental caries was higher than in the control group, regardless of age (SMD 0.98, CI 0.27, 1.69), or gender (SMD 0.77, CI 0.45, 1.10). The salivary parameters assessed had lower levels in children affected by dental caries (p < 0.05).
The levels of oxidative stress biomarkers and salivary parameters are altered in saliva of children with dental caries.
•Biomarkers of salivary oxidative stress are influenced by dental caries.•Antioxidant systems are increased in children affected by dental caries.•Biomarkers of oxidative damage are reduced in saliva of children with dental caries.•Salivary parameters are reduced in children with caries lesions.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35500456</pmid><doi>10.1016/j.archoralbio.2022.105432</doi><tpages>1</tpages></addata></record> |
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| subjects | Antioxidants - metabolism Biomarker Biomarkers - metabolism Child Dental caries Dental Caries - metabolism Humans Oxidative damage Oxidative Stress Saliva Saliva - chemistry Salivary proteins and peptides Superoxide Dismutase - metabolism |
| title | Salivary biomarkers of oxidative stress in children with dental caries: Systematic review and meta-analysis |
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