The chemical structure impairs the intensity of genotoxic effects promoted by 1,2-unsaturated pyrrolizidine alkaloids in vitro

1,2-unsaturated pyrrolizidine alkaloids (PAs) represent a large group of secondary plant metabolites exhibiting hepatotoxic, genotoxic, and carcinogenic properties upon bioactivation. To examine how the degree of esterification affects the genotoxic profile of PA we investigated cytotoxicity, histon...

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Veröffentlicht in:	Food and chemical toxicology 2022-06, Vol.164, p.113049-113049, Article 113049
Hauptverfasser:	Buchmueller, Julia, Enge, Anne-Margarethe, Peters, Antonia, Ebmeyer, Johanna, Küpper, Jan-Heiner, Schäfer, Bernd, Braeuning, Albert, Hessel-Pras, Stefanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneugen Cell cycle Comet assay Micronucleus assay Pyrrolizidine alkaloids γ-H2AX assay
Online-Zugang:	Volltext
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