Potent microtubule-depolymerizing activity of a mitotic Kif18b-MCAK-EB network

The precise regulation of microtubule length during mitosis is essential to assemble and position the mitotic spindle and segregate chromosomes. The kinesin-13 Kif2C or MCAK acts as a potent microtubule depolymerase that diffuses short distances on microtubules, whereas the kinesin-8 Kif18b is a pro...

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Veröffentlicht in:	Journal of cell science 2023-03, Vol.136 (5)
Hauptverfasser:	McHugh, Toni, Welburn, Julie P I
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosome Segregation Kinesins - genetics Microtubules - metabolism Mitosis Spindle Apparatus - metabolism
Online-Zugang:	Volltext
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