Conformational adaptability determining antibody recognition to distomer: structure analysis of enantioselective antibody against chiral drug gatifloxacin

Enantioselective antibodies have great potential to separate and detect chiral compounds. However, cross-reactivity of enantioselective antibodies to the distomer may limit the application. An in-depth understanding of interactions between antibodies and chiral drugs could be helpful to investigate...

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Veröffentlicht in:	RSC advances 2021-12, Vol.11 (62), p.39534-39544
Hauptverfasser:	Wang, Lanteng, Xie, Wei, Jiao, Wenyang, Zhang, Chijian, Li, Xiangmei, Xu, Zhenlin, Huang, Xin-an, Lei, Hongtao, Shen, Xing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptability Antibodies Binding Chemistry Crystal structure Drugs Enantiomers Immunoassay Ligands Molecular docking Molecular dynamics Monoclonal antibodies Reactivity Recognition Structural analysis
Online-Zugang:	Volltext
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