Epithelial-to-mesenchymal transition hinders interferon-γ-dependent immunosurveillance in lung cancer cells

The epithelial-to-mesenchymal transition (EMT) is involved in cancer metastasis; nevertheless, interferon (IFN)-γ induces anticancer activities by causing cell growth suppression, cytotoxicity, and migration inhibition. Regarding the poor response to exogenously administered IFN-γ as anticancer ther...

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Veröffentlicht in:	Cancer letters 2022-07, Vol.539, p.215712-215712, Article 215712
Hauptverfasser:	Tseng, Po-Chun, Chen, Chia-Ling, Lee, Kang-Yuan, Feng, Po-Hao, Wang, Yu-Chih, Satria, Rahmat Dani, Lin, Chiou-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Antioxidants Apoptosis Cell adhesion & migration Cell culture Cell Line, Tumor Cell migration Cell Movement - immunology Cytokines Cytotoxicity EMT Epithelial-Mesenchymal Transition - immunology Gene expression Genetic engineering Genomic analysis Growth factors Homology Humans Hypoxia IFN-γ Immunologic Surveillance Immunosurveillance Interferon-gamma - immunology Interferon-gamma - pharmacology Kinases Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - immunology Lung Neoplasms - pathology Major histocompatibility complex Mesenchyme Metastases Metastasis MHC Migration inhibition Monoclonal antibodies Morphology Phosphatase Proteins Software STAT1 TRAIL protein Transcription activation Tumor necrosis factor-TNF Xenografts γ-Interferon
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