Transforming Growth Factor Beta Promotes the Expansion of Cancer Stem Cells via S1PR3 by Ligand-Independent Notch Activation

Growing evidence suggests that cancer originates from cancer stem cells (CSCs), which can be identified by aldehyde dehydrogenase (ALDH) activity-based flow cytometry. However, the regulation of CSC growth is not fully understood. In the present study, we investigated the effects of Transforming Gro...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2022/05/01, Vol.45(5), pp.649-658
Hauptverfasser:	Hirata, Naoya, Yamada, Shigeru, Yanagida, Shota, Ono, Atsushi, Yasuhiko, Yukuto, Kanda, Yasunari
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde dehydrogenase ALK5 Breast Cancer cancer stem cell Flow cytometry Growth factors Kinases Ligands Neoplasms Neoplastic Stem Cells Notch Phosphorylation Signal Transduction Sphingosine 1-phosphate Sphingosine kinase sphingosine kinase 1 (SphK1) sphingosine-1-phosphate (S1P) Stem cells Transforming Growth Factor beta - pharmacology Transforming growth factor-b Transforming Growth Factor-β (TGFβ)
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