Preservation of heparin-binding EGF-like growth factor activity on heparin-modified poly(-isopropylacrylamide)-grafted surfaces

A heparin-modified poly( N -isopropylacrylamide) (PIPAAm)-grafted surface bound with heparin-binding epidermal growth factor-like growth factor (HB-EGF) was able to culture hepatocytes maintaining high albumin secretion and high expression of hepatocyte-specific genes. However, the activity of HB-EG...

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