Emodin palliates high-fat diet-induced nonalcoholic fatty liver disease in mice via activating the farnesoid X receptor pathway

Cassia mimosoides Linn (CMD) is a traditional Chinese herb that clears liver heat and dampness. It has been widely administered in clinical practice to treat jaundice associated with damp-heat pathogen and obesity. Emodin (EMO) is a major bioactive constituent of CMD that has apparent therapeutic ef...

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Veröffentlicht in:	Journal of ethnopharmacology 2021-10, Vol.279 (NA), p.114340-114340, Article 114340
Hauptverfasser:	Shen, Chuangpeng, Pan, Zhisen, Wu, Shuangcheng, Zheng, Mingxuan, Zhong, Chong, Xin, Xiaoyi, Lan, Shaoyang, Zhu, Zhangzhi, Liu, Min, Wu, Haoxiang, Huang, Qingyin, Zhang, Junmei, Liu, Zhangzhou, Si, Yuqi, Tu, Haitao, Deng, Zhijun, Yu, Yuanyuan, Liu, Hong, Zhong, Yanhua, Guo, Jiewen, Cai, Jiazhong, Xian, Shaoxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cassia - chemistry Cassia mimosoides Linn Diet, High-Fat - adverse effects Dose-Response Relationship, Drug Emodin Emodin - administration & dosage Emodin - isolation & purification Emodin - pharmacology Farnesoid X receptor Glucose - metabolism Hepatocytes - drug effects Hepatocytes - metabolism High fat diet Inflammation - drug therapy Inflammation - pathology Insulin Resistance Lipid and glucose metabolism Lipid Metabolism - drug effects Male Mice Mice, Inbred C57BL Mice, Knockout Non-alcoholic fatty liver Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - physiopathology Oxidative Stress - drug effects Receptors, Cytoplasmic and Nuclear - genetics RNA, Messenger - metabolism Triglycerides - blood
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