Zymogen-poor acinic cell carcinoma of the soft palate with high-grade transformation

Zymogen-poor acinic cell carcinoma of the soft palate with high-grade transformation

Acinic cell carcinoma is an uncommon malignant salivary gland tumour accounting for approximately 6-7% of all salivary gland neoplasms. The key diagnostic feature of acinic cell carcinoma is the presence of acinar cell differentiation characterised by cytoplasmic zymogen secretory granules. This tum...

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Veröffentlicht in:Malaysian journal of pathology 2022-04, Vol.44 (1), p.121-127
Hauptverfasser: Kallarakkal, T G, Ismail, S M, Goh, Y C
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Sprache:eng
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Carcinoma, Acinar Cell - pathology
Enzyme Precursors
Female
Humans
Middle Aged
Palate, Soft - pathology
Salivary Gland Neoplasms - pathology
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creator Kallarakkal, T G
Ismail, S M
Goh, Y C
description Acinic cell carcinoma is an uncommon malignant salivary gland tumour accounting for approximately 6-7% of all salivary gland neoplasms. The key diagnostic feature of acinic cell carcinoma is the presence of acinar cell differentiation characterised by cytoplasmic zymogen secretory granules. This tumour shows a variety of growth patterns, including solid, microcystic, follicular and papillary cystic patterns. Acinic cell carcinoma is typically a cytologically low-grade malignancy. Acinic cell carcinomas with high-grade transformation (HGT) are exceedingly rare and are reported to have a more aggressive clinical course than conventional acinic cell carcinoma. This is a case report of this uncommon entity with high-grade transformation arising on the soft palate in a 64-year-old woman.
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source MEDLINE; EZB-FREE-00999 freely available EZB journals
subjects Carcinoma, Acinar Cell - pathology
Enzyme Precursors
Female
Humans
Middle Aged
Palate, Soft - pathology
Salivary Gland Neoplasms - pathology
title Zymogen-poor acinic cell carcinoma of the soft palate with high-grade transformation
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