Substantial variability in ovarian conservation at hysterectomy for endometrial hyperplasia
Although ovarian conservation at hysterectomy for benign gynecologic disease has demonstrated mortality benefit in young patients and this benefit may be sustained up to age 65 years, there is a scarcity of data regarding ovarian conservation in those with a diagnosis of endometrial hyperplasia, a p...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2022-08, Vol.227 (2), p.255.e1-255.e18 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Matsuo, Koji Violette, Caroline J. Mandelbaum, Rachel S. Harris, Chelsey A. Tavakoli, Amin Klar, Maximilian Shoupe, Donna Roman, Lynda D. |
| description | Although ovarian conservation at hysterectomy for benign gynecologic disease has demonstrated mortality benefit in young patients and this benefit may be sustained up to age 65 years, there is a scarcity of data regarding ovarian conservation in those with a diagnosis of endometrial hyperplasia, a premalignant uterine condition.
This study aimed to examine patient, hospital, treatment, and histology characteristics related to ovarian conservation at the time of inpatient hysterectomy for endometrial hyperplasia.
The Healthcare Cost and Utilization Project’s National Inpatient Sample was retrospectively queried to examine patients aged ≤65 years with endometrial hyperplasia who had inpatient hysterectomy from January 2016 to December 2019. The exclusion criteria included concurrent gynecologic malignancy, adnexal pathology, and lymphadenectomy. Cases were grouped by adnexal surgery status (ovarian conservation or oophorectomy). A multivariable binary logistic regression model was used to identify independent characteristics for ovarian conservation. A classification tree was constructed with recursive partitioning analysis to examine utilization patterns of ovarian conservation.
Overall, 3105 patients (31.1%) underwent ovarian conservation at hysterectomy among 9975 patients. The utilization of ovarian conservation decreased gradually until age 45 years and then markedly decreased by age 52 years (63.3%–15.3%; P |
| doi_str_mv | 10.1016/j.ajog.2022.04.032 |
| format | Article |
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This study aimed to examine patient, hospital, treatment, and histology characteristics related to ovarian conservation at the time of inpatient hysterectomy for endometrial hyperplasia.
The Healthcare Cost and Utilization Project’s National Inpatient Sample was retrospectively queried to examine patients aged ≤65 years with endometrial hyperplasia who had inpatient hysterectomy from January 2016 to December 2019. The exclusion criteria included concurrent gynecologic malignancy, adnexal pathology, and lymphadenectomy. Cases were grouped by adnexal surgery status (ovarian conservation or oophorectomy). A multivariable binary logistic regression model was used to identify independent characteristics for ovarian conservation. A classification tree was constructed with recursive partitioning analysis to examine utilization patterns of ovarian conservation.
Overall, 3105 patients (31.1%) underwent ovarian conservation at hysterectomy among 9975 patients. The utilization of ovarian conservation decreased gradually until age 45 years and then markedly decreased by age 52 years (63.3%–15.3%; P<.001). In a multivariable analysis, younger age, non-White, urban nonteaching centers, and vaginal hysterectomy were associated with increased utilization of ovarian conservation, whereas endometrial hyperplasia with atypia, obesity, comorbidity, large bed capacity centers, and Midwest and South regions were associated with decreased utilization of ovarian conservation (all, P<.05). A classification tree identified 17 utilization patterns for ovarian conservation, ranging from 7.8% to 100.0% (absolute rate difference, 92.2%).
The utilization of ovarian conservation at the time of inpatient hysterectomy in patients undergoing surgical management for endometrial hyperplasia started decreasing in their mid-40s and seemed to occur earlier than in benign hysterectomy. There was substantial variability in ovarian conservation at the time of hysterectomy for endometrial hyperplasia based on patient, hospital, surgical, and histology factors, suggesting the possible benefit of clinical practice guidelines for ovarian conservation in this population.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2022.04.032</identifier><identifier>PMID: 35487326</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>characteristics ; endometrial hyperplasia ; hysterectomy ; ovarian conservation ; utilization</subject><ispartof>American journal of obstetrics and gynecology, 2022-08, Vol.227 (2), p.255.e1-255.e18</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-40e83383118a619550674a747d7cd1618b8bf4014b128b8eeecd05efd4a682a23</citedby><cites>FETCH-LOGICAL-c352t-40e83383118a619550674a747d7cd1618b8bf4014b128b8eeecd05efd4a682a23</cites><orcidid>0000-0002-6232-8701</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2022.04.032$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35487326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsuo, Koji</creatorcontrib><creatorcontrib>Violette, Caroline J.</creatorcontrib><creatorcontrib>Mandelbaum, Rachel S.</creatorcontrib><creatorcontrib>Harris, Chelsey A.</creatorcontrib><creatorcontrib>Tavakoli, Amin</creatorcontrib><creatorcontrib>Klar, Maximilian</creatorcontrib><creatorcontrib>Shoupe, Donna</creatorcontrib><creatorcontrib>Roman, Lynda D.</creatorcontrib><title>Substantial variability in ovarian conservation at hysterectomy for endometrial hyperplasia</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Although ovarian conservation at hysterectomy for benign gynecologic disease has demonstrated mortality benefit in young patients and this benefit may be sustained up to age 65 years, there is a scarcity of data regarding ovarian conservation in those with a diagnosis of endometrial hyperplasia, a premalignant uterine condition.
This study aimed to examine patient, hospital, treatment, and histology characteristics related to ovarian conservation at the time of inpatient hysterectomy for endometrial hyperplasia.
The Healthcare Cost and Utilization Project’s National Inpatient Sample was retrospectively queried to examine patients aged ≤65 years with endometrial hyperplasia who had inpatient hysterectomy from January 2016 to December 2019. The exclusion criteria included concurrent gynecologic malignancy, adnexal pathology, and lymphadenectomy. Cases were grouped by adnexal surgery status (ovarian conservation or oophorectomy). A multivariable binary logistic regression model was used to identify independent characteristics for ovarian conservation. A classification tree was constructed with recursive partitioning analysis to examine utilization patterns of ovarian conservation.
Overall, 3105 patients (31.1%) underwent ovarian conservation at hysterectomy among 9975 patients. The utilization of ovarian conservation decreased gradually until age 45 years and then markedly decreased by age 52 years (63.3%–15.3%; P<.001). In a multivariable analysis, younger age, non-White, urban nonteaching centers, and vaginal hysterectomy were associated with increased utilization of ovarian conservation, whereas endometrial hyperplasia with atypia, obesity, comorbidity, large bed capacity centers, and Midwest and South regions were associated with decreased utilization of ovarian conservation (all, P<.05). A classification tree identified 17 utilization patterns for ovarian conservation, ranging from 7.8% to 100.0% (absolute rate difference, 92.2%).
The utilization of ovarian conservation at the time of inpatient hysterectomy in patients undergoing surgical management for endometrial hyperplasia started decreasing in their mid-40s and seemed to occur earlier than in benign hysterectomy. There was substantial variability in ovarian conservation at the time of hysterectomy for endometrial hyperplasia based on patient, hospital, surgical, and histology factors, suggesting the possible benefit of clinical practice guidelines for ovarian conservation in this population.</description><subject>characteristics</subject><subject>endometrial hyperplasia</subject><subject>hysterectomy</subject><subject>ovarian conservation</subject><subject>utilization</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EoqXwBxhQRpYEf8VxJRZU8SVVYgAmBstxLtRVEhfbrZR_T0ILI9PdSc_7SvcgdElwRjARN-tMr91nRjGlGeYZZvQITQmeF6mQQh6jKcaYpnNWyAk6C2E9nnROT9GE5VwWjIop-njdliHqLlrdJDvtrS5tY2Of2C5xP3eXGNcF8DsdresSHZNVHyJ4MNG1fVI7n0BXuRaiHztW_Qb8ptHB6nN0UusmwMVhztD7w_3b4ildvjw-L-6WqWE5jSnHIBmTjBCpBZnnORYF1wUvqsJURBBZyrLmmPCS0GEHAFPhHOqKayGppmyGrve9G---thCiam0w0DS6A7cNiopcUkY55wNK96jxLgQPtdp422rfK4LVKFWt1ShVjVIV5mqQOoSuDv3bsoXqL_JrcQBu9wAMX-4seBWMhc5AZUdNqnL2v_5vyDuJuw</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Matsuo, Koji</creator><creator>Violette, Caroline J.</creator><creator>Mandelbaum, Rachel S.</creator><creator>Harris, Chelsey A.</creator><creator>Tavakoli, Amin</creator><creator>Klar, Maximilian</creator><creator>Shoupe, Donna</creator><creator>Roman, Lynda D.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6232-8701</orcidid></search><sort><creationdate>20220801</creationdate><title>Substantial variability in ovarian conservation at hysterectomy for endometrial hyperplasia</title><author>Matsuo, Koji ; Violette, Caroline J. ; Mandelbaum, Rachel S. ; Harris, Chelsey A. ; Tavakoli, Amin ; Klar, Maximilian ; Shoupe, Donna ; Roman, Lynda D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-40e83383118a619550674a747d7cd1618b8bf4014b128b8eeecd05efd4a682a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>characteristics</topic><topic>endometrial hyperplasia</topic><topic>hysterectomy</topic><topic>ovarian conservation</topic><topic>utilization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuo, Koji</creatorcontrib><creatorcontrib>Violette, Caroline J.</creatorcontrib><creatorcontrib>Mandelbaum, Rachel S.</creatorcontrib><creatorcontrib>Harris, Chelsey A.</creatorcontrib><creatorcontrib>Tavakoli, Amin</creatorcontrib><creatorcontrib>Klar, Maximilian</creatorcontrib><creatorcontrib>Shoupe, Donna</creatorcontrib><creatorcontrib>Roman, Lynda D.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsuo, Koji</au><au>Violette, Caroline J.</au><au>Mandelbaum, Rachel S.</au><au>Harris, Chelsey A.</au><au>Tavakoli, Amin</au><au>Klar, Maximilian</au><au>Shoupe, Donna</au><au>Roman, Lynda D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substantial variability in ovarian conservation at hysterectomy for endometrial hyperplasia</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>227</volume><issue>2</issue><spage>255.e1</spage><epage>255.e18</epage><pages>255.e1-255.e18</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>Although ovarian conservation at hysterectomy for benign gynecologic disease has demonstrated mortality benefit in young patients and this benefit may be sustained up to age 65 years, there is a scarcity of data regarding ovarian conservation in those with a diagnosis of endometrial hyperplasia, a premalignant uterine condition.
This study aimed to examine patient, hospital, treatment, and histology characteristics related to ovarian conservation at the time of inpatient hysterectomy for endometrial hyperplasia.
The Healthcare Cost and Utilization Project’s National Inpatient Sample was retrospectively queried to examine patients aged ≤65 years with endometrial hyperplasia who had inpatient hysterectomy from January 2016 to December 2019. The exclusion criteria included concurrent gynecologic malignancy, adnexal pathology, and lymphadenectomy. Cases were grouped by adnexal surgery status (ovarian conservation or oophorectomy). A multivariable binary logistic regression model was used to identify independent characteristics for ovarian conservation. A classification tree was constructed with recursive partitioning analysis to examine utilization patterns of ovarian conservation.
Overall, 3105 patients (31.1%) underwent ovarian conservation at hysterectomy among 9975 patients. The utilization of ovarian conservation decreased gradually until age 45 years and then markedly decreased by age 52 years (63.3%–15.3%; P<.001). In a multivariable analysis, younger age, non-White, urban nonteaching centers, and vaginal hysterectomy were associated with increased utilization of ovarian conservation, whereas endometrial hyperplasia with atypia, obesity, comorbidity, large bed capacity centers, and Midwest and South regions were associated with decreased utilization of ovarian conservation (all, P<.05). A classification tree identified 17 utilization patterns for ovarian conservation, ranging from 7.8% to 100.0% (absolute rate difference, 92.2%).
The utilization of ovarian conservation at the time of inpatient hysterectomy in patients undergoing surgical management for endometrial hyperplasia started decreasing in their mid-40s and seemed to occur earlier than in benign hysterectomy. There was substantial variability in ovarian conservation at the time of hysterectomy for endometrial hyperplasia based on patient, hospital, surgical, and histology factors, suggesting the possible benefit of clinical practice guidelines for ovarian conservation in this population.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35487326</pmid><doi>10.1016/j.ajog.2022.04.032</doi><orcidid>https://orcid.org/0000-0002-6232-8701</orcidid></addata></record> |
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| subjects | characteristics endometrial hyperplasia hysterectomy ovarian conservation utilization |
| title | Substantial variability in ovarian conservation at hysterectomy for endometrial hyperplasia |
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