Identification of nitrofuranylchalcone tethered benzoxazole-2-amines as potent inhibitors of drug resistant Mycobacterium tuberculosis demonstrating bactericidal efficacy

[Display omitted] •New benzoxazole-2-amine linked chalcone hybrids were developed.•Antimycobacterial and antibacterial screening indicated selectivity towards Mtb.•Cell viability test against Vero cells was performed to determine toxicity.•Activity against clinical isolates of drug-resistant Mtb str...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2022-06, Vol.64, p.116777-116777, Article 116777
Hauptverfasser:	Kumar Sahoo, Santosh, Maddipatla, Sarvan, Nageswara Rao Gajula, Siva, Naiyaz Ahmad, Mohammad, Kaul, Grace, Nanduri, Srinivas, Sonti, Rajesh, Dasgupta, Arunava, Chopra, Sidharth, Madhavi Yaddanapudi, Venkata
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoxazole-2-amine-chalcone hybrids Metabolic stability Nitrofuran Smile rearrangement Time kill kinetics Tuberculosis
Online-Zugang:	Volltext
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