Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment
Tardive dyskinesia (TD) has a high prevalence and is one of the distressing side effects of antipsychotic medications. Few studies have explored the relationship between TD, clinical correlates, and cognition. The aim of this study was to assess the prevalence, clinical correlates and cognitive impa...
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Veröffentlicht in: | Journal of psychiatric research 2022-07, Vol.151, p.181-187 |
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creator | Liang, Qilin Wang, Dongmei Zhou, Huixia Chen, Dachun Xiu, Meihong Cui, Lixia Zhang, Xiangyang |
description | Tardive dyskinesia (TD) has a high prevalence and is one of the distressing side effects of antipsychotic medications. Few studies have explored the relationship between TD, clinical correlates, and cognition. The aim of this study was to assess the prevalence, clinical correlates and cognitive impairment of co-occurring TD in Chinese patients with schizophrenia.
We recruited 655 patients with chronic schizophrenia who met the DSM-IV diagnostic criteria for schizophrenia and collected clinical and demographic data. All patients were assessed using the Abnormal Involuntary Movement Scale (AIMS) for the severity of TD, Positive and Negative Syndrome Scale (PANSS) for psychopathological symptoms, and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition.
The overall TD prevalence was 41.1%, 42.9% (246/574) in men and 28.4% (23/81) in women (χ2 = 6.1 df = 1, p |
doi_str_mv | 10.1016/j.jpsychires.2022.04.029 |
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We recruited 655 patients with chronic schizophrenia who met the DSM-IV diagnostic criteria for schizophrenia and collected clinical and demographic data. All patients were assessed using the Abnormal Involuntary Movement Scale (AIMS) for the severity of TD, Positive and Negative Syndrome Scale (PANSS) for psychopathological symptoms, and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition.
The overall TD prevalence was 41.1%, 42.9% (246/574) in men and 28.4% (23/81) in women (χ2 = 6.1 df = 1, p < 0.05). There were significant differences in age, sex, duration of illness, number of hospitalizations, drug type, smoking and PANSS negative symptom subscore between TD and non-TD groups (all p < 0.05). Moreover, patients with TD scored lower for immediate memory, attention, delayed memory, and RBANS total scores (all p < 0.05). Logistic regression showed a significant correlation between TD and age, sex, drug type and attention subscore.
Our results suggest that multiple demographic and clinical variables may be associated with the development of TD. Moreover, TD patients may exhibit more cognitive impairment than non-TD patients.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2022.04.029</identifier><identifier>PMID: 35489178</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Clinical symptom ; Cognition ; Schizophrenia ; Tardive dyskinesia</subject><ispartof>Journal of psychiatric research, 2022-07, Vol.151, p.181-187</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-87e960c487491eacbd555a7fb7dd2f45e05743fbe64a1c4cfaeee2c4ade047ec3</citedby><cites>FETCH-LOGICAL-c374t-87e960c487491eacbd555a7fb7dd2f45e05743fbe64a1c4cfaeee2c4ade047ec3</cites><orcidid>0000-0002-9230-7530</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpsychires.2022.04.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35489178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Qilin</creatorcontrib><creatorcontrib>Wang, Dongmei</creatorcontrib><creatorcontrib>Zhou, Huixia</creatorcontrib><creatorcontrib>Chen, Dachun</creatorcontrib><creatorcontrib>Xiu, Meihong</creatorcontrib><creatorcontrib>Cui, Lixia</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><title>Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Tardive dyskinesia (TD) has a high prevalence and is one of the distressing side effects of antipsychotic medications. Few studies have explored the relationship between TD, clinical correlates, and cognition. The aim of this study was to assess the prevalence, clinical correlates and cognitive impairment of co-occurring TD in Chinese patients with schizophrenia.
We recruited 655 patients with chronic schizophrenia who met the DSM-IV diagnostic criteria for schizophrenia and collected clinical and demographic data. All patients were assessed using the Abnormal Involuntary Movement Scale (AIMS) for the severity of TD, Positive and Negative Syndrome Scale (PANSS) for psychopathological symptoms, and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition.
The overall TD prevalence was 41.1%, 42.9% (246/574) in men and 28.4% (23/81) in women (χ2 = 6.1 df = 1, p < 0.05). There were significant differences in age, sex, duration of illness, number of hospitalizations, drug type, smoking and PANSS negative symptom subscore between TD and non-TD groups (all p < 0.05). Moreover, patients with TD scored lower for immediate memory, attention, delayed memory, and RBANS total scores (all p < 0.05). Logistic regression showed a significant correlation between TD and age, sex, drug type and attention subscore.
Our results suggest that multiple demographic and clinical variables may be associated with the development of TD. Moreover, TD patients may exhibit more cognitive impairment than non-TD patients.</description><subject>Clinical symptom</subject><subject>Cognition</subject><subject>Schizophrenia</subject><subject>Tardive dyskinesia</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFUU1v1DAQtRAVXdr-BeRjDyTYjhMn3GAFtFKlcihny2tPyCyJk9rZRdt7_zcOW-ixp3nSvA_NPEIoZzlnvPqwzbdTPNgOA8RcMCFyJnMmmldkxWvVZLxQzWuyYmmTFU1ZnZK3MW4ZY0pw-YacFqWsG67qFXm8M8HhHqg7xF_oIaKh6Om6WzDQycwIfo70N84djSnxYZy6AB7NR_o9wN704C28p7ZHj9b01I4hQG9miNR4R_9iHH3scDqa2PGnx3mJxGEyGIbkf05OWtNHuHiaZ-TH1y9366vs5vbb9frTTWYLJeesVtBUzMpayYaDsRtXlqVR7UY5J1pZAiuVLNoNVNJwK21rAEBYaRwwqcAWZ-Ty6DuF8X4HcdYDRgt9bzyMu6hFVdZCNEzWiVofqTaMMQZo9RRwMOGgOdNLCXqrn0vQSwmaSZ1KSNJ3Tym7zQDuv_Df1xPh85EA6dY9QtDR4vJHl7zsrN2IL6f8AdNooxU</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Liang, Qilin</creator><creator>Wang, Dongmei</creator><creator>Zhou, Huixia</creator><creator>Chen, Dachun</creator><creator>Xiu, Meihong</creator><creator>Cui, Lixia</creator><creator>Zhang, Xiangyang</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9230-7530</orcidid></search><sort><creationdate>20220701</creationdate><title>Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment</title><author>Liang, Qilin ; Wang, Dongmei ; Zhou, Huixia ; Chen, Dachun ; Xiu, Meihong ; Cui, Lixia ; Zhang, Xiangyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-87e960c487491eacbd555a7fb7dd2f45e05743fbe64a1c4cfaeee2c4ade047ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Clinical symptom</topic><topic>Cognition</topic><topic>Schizophrenia</topic><topic>Tardive dyskinesia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Qilin</creatorcontrib><creatorcontrib>Wang, Dongmei</creatorcontrib><creatorcontrib>Zhou, Huixia</creatorcontrib><creatorcontrib>Chen, Dachun</creatorcontrib><creatorcontrib>Xiu, Meihong</creatorcontrib><creatorcontrib>Cui, Lixia</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Qilin</au><au>Wang, Dongmei</au><au>Zhou, Huixia</au><au>Chen, Dachun</au><au>Xiu, Meihong</au><au>Cui, Lixia</au><au>Zhang, Xiangyang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>151</volume><spage>181</spage><epage>187</epage><pages>181-187</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Tardive dyskinesia (TD) has a high prevalence and is one of the distressing side effects of antipsychotic medications. Few studies have explored the relationship between TD, clinical correlates, and cognition. The aim of this study was to assess the prevalence, clinical correlates and cognitive impairment of co-occurring TD in Chinese patients with schizophrenia.
We recruited 655 patients with chronic schizophrenia who met the DSM-IV diagnostic criteria for schizophrenia and collected clinical and demographic data. All patients were assessed using the Abnormal Involuntary Movement Scale (AIMS) for the severity of TD, Positive and Negative Syndrome Scale (PANSS) for psychopathological symptoms, and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition.
The overall TD prevalence was 41.1%, 42.9% (246/574) in men and 28.4% (23/81) in women (χ2 = 6.1 df = 1, p < 0.05). There were significant differences in age, sex, duration of illness, number of hospitalizations, drug type, smoking and PANSS negative symptom subscore between TD and non-TD groups (all p < 0.05). Moreover, patients with TD scored lower for immediate memory, attention, delayed memory, and RBANS total scores (all p < 0.05). Logistic regression showed a significant correlation between TD and age, sex, drug type and attention subscore.
Our results suggest that multiple demographic and clinical variables may be associated with the development of TD. Moreover, TD patients may exhibit more cognitive impairment than non-TD patients.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35489178</pmid><doi>10.1016/j.jpsychires.2022.04.029</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9230-7530</orcidid></addata></record> |
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subjects | Clinical symptom Cognition Schizophrenia Tardive dyskinesia |
title | Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment |
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