Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment

Tardive dyskinesia (TD) has a high prevalence and is one of the distressing side effects of antipsychotic medications. Few studies have explored the relationship between TD, clinical correlates, and cognition. The aim of this study was to assess the prevalence, clinical correlates and cognitive impa...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of psychiatric research 2022-07, Vol.151, p.181-187
Hauptverfasser: Liang, Qilin, Wang, Dongmei, Zhou, Huixia, Chen, Dachun, Xiu, Meihong, Cui, Lixia, Zhang, Xiangyang
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 187
container_issue
container_start_page 181
container_title Journal of psychiatric research
container_volume 151
creator Liang, Qilin
Wang, Dongmei
Zhou, Huixia
Chen, Dachun
Xiu, Meihong
Cui, Lixia
Zhang, Xiangyang
description Tardive dyskinesia (TD) has a high prevalence and is one of the distressing side effects of antipsychotic medications. Few studies have explored the relationship between TD, clinical correlates, and cognition. The aim of this study was to assess the prevalence, clinical correlates and cognitive impairment of co-occurring TD in Chinese patients with schizophrenia. We recruited 655 patients with chronic schizophrenia who met the DSM-IV diagnostic criteria for schizophrenia and collected clinical and demographic data. All patients were assessed using the Abnormal Involuntary Movement Scale (AIMS) for the severity of TD, Positive and Negative Syndrome Scale (PANSS) for psychopathological symptoms, and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition. The overall TD prevalence was 41.1%, 42.9% (246/574) in men and 28.4% (23/81) in women (χ2 = 6.1 df = 1, p 
doi_str_mv 10.1016/j.jpsychires.2022.04.029
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2658229048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022395622002321</els_id><sourcerecordid>2658229048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c374t-87e960c487491eacbd555a7fb7dd2f45e05743fbe64a1c4cfaeee2c4ade047ec3</originalsourceid><addsrcrecordid>eNqFUU1v1DAQtRAVXdr-BeRjDyTYjhMn3GAFtFKlcihny2tPyCyJk9rZRdt7_zcOW-ixp3nSvA_NPEIoZzlnvPqwzbdTPNgOA8RcMCFyJnMmmldkxWvVZLxQzWuyYmmTFU1ZnZK3MW4ZY0pw-YacFqWsG67qFXm8M8HhHqg7xF_oIaKh6Om6WzDQycwIfo70N84djSnxYZy6AB7NR_o9wN704C28p7ZHj9b01I4hQG9miNR4R_9iHH3scDqa2PGnx3mJxGEyGIbkf05OWtNHuHiaZ-TH1y9366vs5vbb9frTTWYLJeesVtBUzMpayYaDsRtXlqVR7UY5J1pZAiuVLNoNVNJwK21rAEBYaRwwqcAWZ-Ty6DuF8X4HcdYDRgt9bzyMu6hFVdZCNEzWiVofqTaMMQZo9RRwMOGgOdNLCXqrn0vQSwmaSZ1KSNJ3Tym7zQDuv_Df1xPh85EA6dY9QtDR4vJHl7zsrN2IL6f8AdNooxU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2658229048</pqid></control><display><type>article</type><title>Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment</title><source>Access via ScienceDirect (Elsevier)</source><creator>Liang, Qilin ; Wang, Dongmei ; Zhou, Huixia ; Chen, Dachun ; Xiu, Meihong ; Cui, Lixia ; Zhang, Xiangyang</creator><creatorcontrib>Liang, Qilin ; Wang, Dongmei ; Zhou, Huixia ; Chen, Dachun ; Xiu, Meihong ; Cui, Lixia ; Zhang, Xiangyang</creatorcontrib><description>Tardive dyskinesia (TD) has a high prevalence and is one of the distressing side effects of antipsychotic medications. Few studies have explored the relationship between TD, clinical correlates, and cognition. The aim of this study was to assess the prevalence, clinical correlates and cognitive impairment of co-occurring TD in Chinese patients with schizophrenia. We recruited 655 patients with chronic schizophrenia who met the DSM-IV diagnostic criteria for schizophrenia and collected clinical and demographic data. All patients were assessed using the Abnormal Involuntary Movement Scale (AIMS) for the severity of TD, Positive and Negative Syndrome Scale (PANSS) for psychopathological symptoms, and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition. The overall TD prevalence was 41.1%, 42.9% (246/574) in men and 28.4% (23/81) in women (χ2 = 6.1 df = 1, p &lt; 0.05). There were significant differences in age, sex, duration of illness, number of hospitalizations, drug type, smoking and PANSS negative symptom subscore between TD and non-TD groups (all p &lt; 0.05). Moreover, patients with TD scored lower for immediate memory, attention, delayed memory, and RBANS total scores (all p &lt; 0.05). Logistic regression showed a significant correlation between TD and age, sex, drug type and attention subscore. Our results suggest that multiple demographic and clinical variables may be associated with the development of TD. Moreover, TD patients may exhibit more cognitive impairment than non-TD patients.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2022.04.029</identifier><identifier>PMID: 35489178</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Clinical symptom ; Cognition ; Schizophrenia ; Tardive dyskinesia</subject><ispartof>Journal of psychiatric research, 2022-07, Vol.151, p.181-187</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-87e960c487491eacbd555a7fb7dd2f45e05743fbe64a1c4cfaeee2c4ade047ec3</citedby><cites>FETCH-LOGICAL-c374t-87e960c487491eacbd555a7fb7dd2f45e05743fbe64a1c4cfaeee2c4ade047ec3</cites><orcidid>0000-0002-9230-7530</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpsychires.2022.04.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35489178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Qilin</creatorcontrib><creatorcontrib>Wang, Dongmei</creatorcontrib><creatorcontrib>Zhou, Huixia</creatorcontrib><creatorcontrib>Chen, Dachun</creatorcontrib><creatorcontrib>Xiu, Meihong</creatorcontrib><creatorcontrib>Cui, Lixia</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><title>Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Tardive dyskinesia (TD) has a high prevalence and is one of the distressing side effects of antipsychotic medications. Few studies have explored the relationship between TD, clinical correlates, and cognition. The aim of this study was to assess the prevalence, clinical correlates and cognitive impairment of co-occurring TD in Chinese patients with schizophrenia. We recruited 655 patients with chronic schizophrenia who met the DSM-IV diagnostic criteria for schizophrenia and collected clinical and demographic data. All patients were assessed using the Abnormal Involuntary Movement Scale (AIMS) for the severity of TD, Positive and Negative Syndrome Scale (PANSS) for psychopathological symptoms, and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition. The overall TD prevalence was 41.1%, 42.9% (246/574) in men and 28.4% (23/81) in women (χ2 = 6.1 df = 1, p &lt; 0.05). There were significant differences in age, sex, duration of illness, number of hospitalizations, drug type, smoking and PANSS negative symptom subscore between TD and non-TD groups (all p &lt; 0.05). Moreover, patients with TD scored lower for immediate memory, attention, delayed memory, and RBANS total scores (all p &lt; 0.05). Logistic regression showed a significant correlation between TD and age, sex, drug type and attention subscore. Our results suggest that multiple demographic and clinical variables may be associated with the development of TD. Moreover, TD patients may exhibit more cognitive impairment than non-TD patients.</description><subject>Clinical symptom</subject><subject>Cognition</subject><subject>Schizophrenia</subject><subject>Tardive dyskinesia</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFUU1v1DAQtRAVXdr-BeRjDyTYjhMn3GAFtFKlcihny2tPyCyJk9rZRdt7_zcOW-ixp3nSvA_NPEIoZzlnvPqwzbdTPNgOA8RcMCFyJnMmmldkxWvVZLxQzWuyYmmTFU1ZnZK3MW4ZY0pw-YacFqWsG67qFXm8M8HhHqg7xF_oIaKh6Om6WzDQycwIfo70N84djSnxYZy6AB7NR_o9wN704C28p7ZHj9b01I4hQG9miNR4R_9iHH3scDqa2PGnx3mJxGEyGIbkf05OWtNHuHiaZ-TH1y9366vs5vbb9frTTWYLJeesVtBUzMpayYaDsRtXlqVR7UY5J1pZAiuVLNoNVNJwK21rAEBYaRwwqcAWZ-Ty6DuF8X4HcdYDRgt9bzyMu6hFVdZCNEzWiVofqTaMMQZo9RRwMOGgOdNLCXqrn0vQSwmaSZ1KSNJ3Tym7zQDuv_Df1xPh85EA6dY9QtDR4vJHl7zsrN2IL6f8AdNooxU</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Liang, Qilin</creator><creator>Wang, Dongmei</creator><creator>Zhou, Huixia</creator><creator>Chen, Dachun</creator><creator>Xiu, Meihong</creator><creator>Cui, Lixia</creator><creator>Zhang, Xiangyang</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9230-7530</orcidid></search><sort><creationdate>20220701</creationdate><title>Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment</title><author>Liang, Qilin ; Wang, Dongmei ; Zhou, Huixia ; Chen, Dachun ; Xiu, Meihong ; Cui, Lixia ; Zhang, Xiangyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-87e960c487491eacbd555a7fb7dd2f45e05743fbe64a1c4cfaeee2c4ade047ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Clinical symptom</topic><topic>Cognition</topic><topic>Schizophrenia</topic><topic>Tardive dyskinesia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Qilin</creatorcontrib><creatorcontrib>Wang, Dongmei</creatorcontrib><creatorcontrib>Zhou, Huixia</creatorcontrib><creatorcontrib>Chen, Dachun</creatorcontrib><creatorcontrib>Xiu, Meihong</creatorcontrib><creatorcontrib>Cui, Lixia</creatorcontrib><creatorcontrib>Zhang, Xiangyang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Qilin</au><au>Wang, Dongmei</au><au>Zhou, Huixia</au><au>Chen, Dachun</au><au>Xiu, Meihong</au><au>Cui, Lixia</au><au>Zhang, Xiangyang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>151</volume><spage>181</spage><epage>187</epage><pages>181-187</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Tardive dyskinesia (TD) has a high prevalence and is one of the distressing side effects of antipsychotic medications. Few studies have explored the relationship between TD, clinical correlates, and cognition. The aim of this study was to assess the prevalence, clinical correlates and cognitive impairment of co-occurring TD in Chinese patients with schizophrenia. We recruited 655 patients with chronic schizophrenia who met the DSM-IV diagnostic criteria for schizophrenia and collected clinical and demographic data. All patients were assessed using the Abnormal Involuntary Movement Scale (AIMS) for the severity of TD, Positive and Negative Syndrome Scale (PANSS) for psychopathological symptoms, and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for cognition. The overall TD prevalence was 41.1%, 42.9% (246/574) in men and 28.4% (23/81) in women (χ2 = 6.1 df = 1, p &lt; 0.05). There were significant differences in age, sex, duration of illness, number of hospitalizations, drug type, smoking and PANSS negative symptom subscore between TD and non-TD groups (all p &lt; 0.05). Moreover, patients with TD scored lower for immediate memory, attention, delayed memory, and RBANS total scores (all p &lt; 0.05). Logistic regression showed a significant correlation between TD and age, sex, drug type and attention subscore. Our results suggest that multiple demographic and clinical variables may be associated with the development of TD. Moreover, TD patients may exhibit more cognitive impairment than non-TD patients.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35489178</pmid><doi>10.1016/j.jpsychires.2022.04.029</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-9230-7530</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0022-3956
ispartof Journal of psychiatric research, 2022-07, Vol.151, p.181-187
issn 0022-3956
1879-1379
language eng
recordid cdi_proquest_miscellaneous_2658229048
source Access via ScienceDirect (Elsevier)
subjects Clinical symptom
Cognition
Schizophrenia
Tardive dyskinesia
title Tardive dyskinesia in Chinese patients with schizophrenia: Prevalence, clinical correlates and relationship with cognitive impairment
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T19%3A52%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tardive%20dyskinesia%20in%20Chinese%20patients%20with%20schizophrenia:%20Prevalence,%20clinical%20correlates%20and%20relationship%20with%20cognitive%20impairment&rft.jtitle=Journal%20of%20psychiatric%20research&rft.au=Liang,%20Qilin&rft.date=2022-07-01&rft.volume=151&rft.spage=181&rft.epage=187&rft.pages=181-187&rft.issn=0022-3956&rft.eissn=1879-1379&rft_id=info:doi/10.1016/j.jpsychires.2022.04.029&rft_dat=%3Cproquest_cross%3E2658229048%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2658229048&rft_id=info:pmid/35489178&rft_els_id=S0022395622002321&rfr_iscdi=true