Effects of combination treatment with metformin and berberine on hypoglycemic activity and gut microbiota modulation in db/db mice

•Hypoglycemic effect and gut microbiota modulation after co-treatment with metformin and berberine were for the first time investigated in db/db mice.•Compared with metformin and berberine monotherapy, their co-treatment could further enhance hypoglycemic effects and significantly change composition...

Ausführliche Beschreibung