Infection profile of patients with extracorporeal membrane oxygenation in paediatric cardiac surgery ICU
We investigated the risk of increased nosocomial infections and the associated pathogens in patients who underwent paediatric cardiovascular surgery and were put on extracorporeal membrane oxygenation support. We studied the duration of extracorporeal membrane oxygenation use and other variables tha...
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| Veröffentlicht in: | Cardiology in the young 2022-11, Vol.32 (11), p.1833-1838 |
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| creator | Işık, Mehmet Emirhan Arslanoğlu, Ergin Menekşe, Şirin Uygun-Kızmaz, Yeşim Şavluk, Ömer Faruk Kara, Kenan Abdurrahman Türkmen-Karaağaç, Aysu Ceyran, Hakan |
| description | We investigated the risk of increased nosocomial infections and the associated pathogens in patients who underwent paediatric cardiovascular surgery and were put on extracorporeal membrane oxygenation support. We studied the duration of extracorporeal membrane oxygenation use and other variables that may be associated with increased nosocomial infection risk.
Patients who were treated with an extracorporeal membrane oxygenation in paediatric cardiovascular surgery ICU between 2010 and 2020 were included in this retrospective study. We analysed the site of infection and microbiological profile of infections occurring in these patients according to CDC and National Healthcare Safety Network criteria.
The onset of infection development in patients after extracorporeal membrane oxygenation was found to be median 8 (3-15, 25-75 IQR) days in the whole group, and median 11 (3-16, 25-75 IQR) days in those who developed infection without being put on extracorporeal membrane oxygenation. When patients were divided into those with and without infection, duration of ICU was found to be 19 (16-28, IQR 25-75) days in patients with infection vs. 8 (2-16, IQR 25-75; p: |
| doi_str_mv | 10.1017/S1047951122001263 |
| format | Article |
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Patients who were treated with an extracorporeal membrane oxygenation in paediatric cardiovascular surgery ICU between 2010 and 2020 were included in this retrospective study. We analysed the site of infection and microbiological profile of infections occurring in these patients according to CDC and National Healthcare Safety Network criteria.
The onset of infection development in patients after extracorporeal membrane oxygenation was found to be median 8 (3-15, 25-75 IQR) days in the whole group, and median 11 (3-16, 25-75 IQR) days in those who developed infection without being put on extracorporeal membrane oxygenation. When patients were divided into those with and without infection, duration of ICU was found to be 19 (16-28, IQR 25-75) days in patients with infection vs. 8 (2-16, IQR 25-75; p: <0.001) days in patients without infection. Duration of extracorporeal membrane oxygenation support was found to be 14 (10-25, IQR 25-75) days in patients with infection versus 5 (2-10, IQR 25-75; p: <0.001) days in patients without infection and total hospital stay was 26 (18-33, IQR 25-75) days in patients with infection versus 8 (2-23, IQR 25-75) days in those without infection. A total of 24 patients out of the 70 patients experienced 32 infectious episodes during extracorporeal membrane oxygenation support. Culture-positive infections were detected at a single site in 19 patients, and multiple sites in 5 patients.
We propose that prolonged extracorporeal membrane oxygenation support is associated with an increased risk of infection. Although extracorporeal membrane oxygenation is a life-saving treatment method, prolonged extracorporeal membrane oxygenation may increase the development of infectious complications and the associated mortality and morbidity of the patient.</description><identifier>ISSN: 1047-9511</identifier><identifier>EISSN: 1467-1107</identifier><identifier>DOI: 10.1017/S1047951122001263</identifier><identifier>PMID: 35481466</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Blood tests ; Complications ; Confidence intervals ; Congenital diseases ; Disease control ; Extracorporeal membrane oxygenation ; Health risks ; Heart surgery ; Hospitals ; Intensive Care ; Laboratories ; Membranes ; Morbidity ; Mortality ; Nosocomial infection ; Nosocomial infections ; Original Article ; Oxygenation ; Pathogens ; Patients ; Pediatrics ; Regression analysis ; Risk ; Surgery ; Variables</subject><ispartof>Cardiology in the young, 2022-11, Vol.32 (11), p.1833-1838</ispartof><rights>The Author(s), 2022. Published by Cambridge University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c325t-a3ed749992d741284752dc5ea5d40744000ca0d6654b1123567fbe7fde19d54f3</cites><orcidid>0000-0003-1295-7689</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1047951122001263/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35481466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Işık, Mehmet Emirhan</creatorcontrib><creatorcontrib>Arslanoğlu, Ergin</creatorcontrib><creatorcontrib>Menekşe, Şirin</creatorcontrib><creatorcontrib>Uygun-Kızmaz, Yeşim</creatorcontrib><creatorcontrib>Şavluk, Ömer Faruk</creatorcontrib><creatorcontrib>Kara, Kenan Abdurrahman</creatorcontrib><creatorcontrib>Türkmen-Karaağaç, Aysu</creatorcontrib><creatorcontrib>Ceyran, Hakan</creatorcontrib><title>Infection profile of patients with extracorporeal membrane oxygenation in paediatric cardiac surgery ICU</title><title>Cardiology in the young</title><addtitle>Cardiol Young</addtitle><description>We investigated the risk of increased nosocomial infections and the associated pathogens in patients who underwent paediatric cardiovascular surgery and were put on extracorporeal membrane oxygenation support. We studied the duration of extracorporeal membrane oxygenation use and other variables that may be associated with increased nosocomial infection risk.
Patients who were treated with an extracorporeal membrane oxygenation in paediatric cardiovascular surgery ICU between 2010 and 2020 were included in this retrospective study. We analysed the site of infection and microbiological profile of infections occurring in these patients according to CDC and National Healthcare Safety Network criteria.
The onset of infection development in patients after extracorporeal membrane oxygenation was found to be median 8 (3-15, 25-75 IQR) days in the whole group, and median 11 (3-16, 25-75 IQR) days in those who developed infection without being put on extracorporeal membrane oxygenation. When patients were divided into those with and without infection, duration of ICU was found to be 19 (16-28, IQR 25-75) days in patients with infection vs. 8 (2-16, IQR 25-75; p: <0.001) days in patients without infection. Duration of extracorporeal membrane oxygenation support was found to be 14 (10-25, IQR 25-75) days in patients with infection versus 5 (2-10, IQR 25-75; p: <0.001) days in patients without infection and total hospital stay was 26 (18-33, IQR 25-75) days in patients with infection versus 8 (2-23, IQR 25-75) days in those without infection. A total of 24 patients out of the 70 patients experienced 32 infectious episodes during extracorporeal membrane oxygenation support. Culture-positive infections were detected at a single site in 19 patients, and multiple sites in 5 patients.
We propose that prolonged extracorporeal membrane oxygenation support is associated with an increased risk of infection. Although extracorporeal membrane oxygenation is a life-saving treatment method, prolonged extracorporeal membrane oxygenation may increase the development of infectious complications and the associated mortality and morbidity of the patient.</description><subject>Blood tests</subject><subject>Complications</subject><subject>Confidence intervals</subject><subject>Congenital diseases</subject><subject>Disease control</subject><subject>Extracorporeal membrane oxygenation</subject><subject>Health risks</subject><subject>Heart surgery</subject><subject>Hospitals</subject><subject>Intensive Care</subject><subject>Laboratories</subject><subject>Membranes</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Nosocomial infection</subject><subject>Nosocomial infections</subject><subject>Original Article</subject><subject>Oxygenation</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Regression analysis</subject><subject>Risk</subject><subject>Surgery</subject><subject>Variables</subject><issn>1047-9511</issn><issn>1467-1107</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kUtLHEEQx5sQicbkA-QSGnLxMrGrnztHWXwsCDkYz0Nvd83aMo9N9wy6395SNwkYcqqC-v3_9WLsC4jvIMCd3oDQrjYAUgoB0qp37Ai0dRWAcO8pp3L1XD9kH0u5J0YpEB_YoTJ6QaA9YnerocUwpXHg2zy2qUM-tnzrp4TDVPhDmu44Pk7ZhzFvx4y-4z326-wHAh93Gxz8iziR3mNMfsop8OAzpYGXOW8w7_hqefuJHbS-K_h5H4_Z7cX5z-VVdf3jcrU8u66CkmaqvMLodF3XkgLIhXZGxmDQm6iF01oIEbyI1hq9pr2Vsa5do2sjQh2NbtUxO3n1pXV-zVimpk8lYNfRxONcGmlJYiwoQei3N-j9OOeBpmvkQlkBWitFFLxSIY-lZGybbU69z7sGRPP8huafN5Dm6955XvcY_yh-350AtTf1dMwUN_i39_9tnwABapFo</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Işık, Mehmet Emirhan</creator><creator>Arslanoğlu, Ergin</creator><creator>Menekşe, Şirin</creator><creator>Uygun-Kızmaz, Yeşim</creator><creator>Şavluk, Ömer Faruk</creator><creator>Kara, Kenan Abdurrahman</creator><creator>Türkmen-Karaağaç, Aysu</creator><creator>Ceyran, Hakan</creator><general>Cambridge University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1295-7689</orcidid></search><sort><creationdate>20221101</creationdate><title>Infection profile of patients with extracorporeal membrane oxygenation in paediatric cardiac surgery ICU</title><author>Işık, Mehmet Emirhan ; 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We studied the duration of extracorporeal membrane oxygenation use and other variables that may be associated with increased nosocomial infection risk.
Patients who were treated with an extracorporeal membrane oxygenation in paediatric cardiovascular surgery ICU between 2010 and 2020 were included in this retrospective study. We analysed the site of infection and microbiological profile of infections occurring in these patients according to CDC and National Healthcare Safety Network criteria.
The onset of infection development in patients after extracorporeal membrane oxygenation was found to be median 8 (3-15, 25-75 IQR) days in the whole group, and median 11 (3-16, 25-75 IQR) days in those who developed infection without being put on extracorporeal membrane oxygenation. When patients were divided into those with and without infection, duration of ICU was found to be 19 (16-28, IQR 25-75) days in patients with infection vs. 8 (2-16, IQR 25-75; p: <0.001) days in patients without infection. Duration of extracorporeal membrane oxygenation support was found to be 14 (10-25, IQR 25-75) days in patients with infection versus 5 (2-10, IQR 25-75; p: <0.001) days in patients without infection and total hospital stay was 26 (18-33, IQR 25-75) days in patients with infection versus 8 (2-23, IQR 25-75) days in those without infection. A total of 24 patients out of the 70 patients experienced 32 infectious episodes during extracorporeal membrane oxygenation support. Culture-positive infections were detected at a single site in 19 patients, and multiple sites in 5 patients.
We propose that prolonged extracorporeal membrane oxygenation support is associated with an increased risk of infection. Although extracorporeal membrane oxygenation is a life-saving treatment method, prolonged extracorporeal membrane oxygenation may increase the development of infectious complications and the associated mortality and morbidity of the patient.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>35481466</pmid><doi>10.1017/S1047951122001263</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1295-7689</orcidid></addata></record> |
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| subjects | Blood tests Complications Confidence intervals Congenital diseases Disease control Extracorporeal membrane oxygenation Health risks Heart surgery Hospitals Intensive Care Laboratories Membranes Morbidity Mortality Nosocomial infection Nosocomial infections Original Article Oxygenation Pathogens Patients Pediatrics Regression analysis Risk Surgery Variables |
| title | Infection profile of patients with extracorporeal membrane oxygenation in paediatric cardiac surgery ICU |
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