Real‐world multicentre observational study including population pharmacokinetic modelling to evaluate the exposure–response relationship of vedolizumab in inflammatory bowel disease: ERELATE Study

Summary Background ERELATE was a phase 4, multinational, retrospective, observational study. Aim To evaluate the relationship between intravenous vedolizumab exposure and treatment outcomes over 52 weeks in adults with ulcerative colitis (UC) or Crohn’s disease (CD). Methods Real‐world data from pat...

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Veröffentlicht in:	Alimentary pharmacology & therapeutics 2022-08, Vol.56 (3), p.463-476
Hauptverfasser:	Vande Casteele, Niels, Sandborn, William J., Feagan, Brian G., Vermeire, Séverine, Dulai, Parambir S., Yarur, Andres, Roblin, Xavier, Ben‐Horin, Shomron, Dotan, Iris, Osterman, Mark T., Rosario, Maria, Osborn, Teresa McRorie, Panes, Julian, Lindner, Dirk, Agboton, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Bayesian analysis Clinical outcomes Crohn's disease Endoscopy Inflammatory bowel diseases Intravenous administration Observational studies Patients Pharmacokinetics Population studies Remission Remission (Medicine) Tumor necrosis factor Tumors Ulcerative colitis
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