The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis
Background Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation and neoangiogenesis. The disease pathogenesis has not been fully elucidated. The proteins, a disintegrin and metalloproteinase (ADAM)10 and ADAM17, are important proteases serving as regula...
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| Veröffentlicht in: | Clinical and experimental dermatology 2022-09, Vol.47 (9), p.1673-1678 |
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| container_issue | 9 |
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| container_title | Clinical and experimental dermatology |
| container_volume | 47 |
| creator | Gül, Ceren Kilic, Sevilay Şehitoğlu, Müşerref Hilal |
| description | Background
Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation and neoangiogenesis. The disease pathogenesis has not been fully elucidated. The proteins, a disintegrin and metalloproteinase (ADAM)10 and ADAM17, are important proteases serving as regulators of inflammation.
Aim
To determine the role of ADAM10 and ADAM17 in the pathogenesis of psoriasis through the comparison of their serum levels in patients with psoriasis and healthy controls (HCs).
Methods
In total, 179 participants (90 patients with psoriasis and 89 HCs) were enrolled in the study. Levels of ADAM10 and ADAM17 in serum were measured by ELISA for each participant from the patient and HC groups. The statistical data analysis was performed using SPSS (V19.0) and P |
| doi_str_mv | 10.1111/ced.15239 |
| format | Article |
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Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation and neoangiogenesis. The disease pathogenesis has not been fully elucidated. The proteins, a disintegrin and metalloproteinase (ADAM)10 and ADAM17, are important proteases serving as regulators of inflammation.
Aim
To determine the role of ADAM10 and ADAM17 in the pathogenesis of psoriasis through the comparison of their serum levels in patients with psoriasis and healthy controls (HCs).
Methods
In total, 179 participants (90 patients with psoriasis and 89 HCs) were enrolled in the study. Levels of ADAM10 and ADAM17 in serum were measured by ELISA for each participant from the patient and HC groups. The statistical data analysis was performed using SPSS (V19.0) and P < 0.05 was considered statistically significant.
Results
The mean values for serum ADAM10 and ADAM17 were, respectively, 3.1 ± 2.2 and 76.5 ± 31.1 in the psoriasis group and 8.6 ± 3.7 and 29.5 ± 22.4 in the HC group. A statistically significant difference between the patient and HC groups was detected for both ADAM10 and ADAM17 levels (P = 0.001).
Conclusion
Considering the high levels of ADAM17 in the psoriasis group, ADAM17 protease might have a crucial role in the pathogenesis of psoriasis, while the low levels of ADAM10 might be attributable to its regulatory effect on keratinocyte differentiation and proliferation.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/ced.15239</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Pathogenesis ; Psoriasis ; Serum levels ; Skin diseases ; Statistical analysis</subject><ispartof>Clinical and experimental dermatology, 2022-09, Vol.47 (9), p.1673-1678</ispartof><rights>2022 British Association of Dermatologists.</rights><rights>Copyright © 2022 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2609-c7e3091e55bed329703d7d4af078d10c70e45cd017f5a7fbc524c388bb8348b83</citedby><cites>FETCH-LOGICAL-c2609-c7e3091e55bed329703d7d4af078d10c70e45cd017f5a7fbc524c388bb8348b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Gül, Ceren</creatorcontrib><creatorcontrib>Kilic, Sevilay</creatorcontrib><creatorcontrib>Şehitoğlu, Müşerref Hilal</creatorcontrib><title>The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis</title><title>Clinical and experimental dermatology</title><description>Background
Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation and neoangiogenesis. The disease pathogenesis has not been fully elucidated. The proteins, a disintegrin and metalloproteinase (ADAM)10 and ADAM17, are important proteases serving as regulators of inflammation.
Aim
To determine the role of ADAM10 and ADAM17 in the pathogenesis of psoriasis through the comparison of their serum levels in patients with psoriasis and healthy controls (HCs).
Methods
In total, 179 participants (90 patients with psoriasis and 89 HCs) were enrolled in the study. Levels of ADAM10 and ADAM17 in serum were measured by ELISA for each participant from the patient and HC groups. The statistical data analysis was performed using SPSS (V19.0) and P < 0.05 was considered statistically significant.
Results
The mean values for serum ADAM10 and ADAM17 were, respectively, 3.1 ± 2.2 and 76.5 ± 31.1 in the psoriasis group and 8.6 ± 3.7 and 29.5 ± 22.4 in the HC group. A statistically significant difference between the patient and HC groups was detected for both ADAM10 and ADAM17 levels (P = 0.001).
Conclusion
Considering the high levels of ADAM17 in the psoriasis group, ADAM17 protease might have a crucial role in the pathogenesis of psoriasis, while the low levels of ADAM10 might be attributable to its regulatory effect on keratinocyte differentiation and proliferation.</description><subject>Pathogenesis</subject><subject>Psoriasis</subject><subject>Serum levels</subject><subject>Skin diseases</subject><subject>Statistical analysis</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kE1vwjAMhqNpk8bYDvsHlXaBQ8FJSNMeEbAPiWkXdo5C6kJQabqkaOLfL8BOk-ZDbCuPX1svIY8URjTG2GA5ooLx4or0KM9EyhiHa9IDDjLNCp7fkrsQdgCUUyl6ZLfaYmL3rfOdbgwmrkp0Utpgmw433jaJbspkj52ua9d616FtdMBkMJ1P34cUzt-nmsokwl0Ua3W3dRtsMNhwkmuD81bH5p7cVLoO-PCb--TzebGavabLj5e32XSZGpZBkRqJHAqKQqyx5KyQwEtZTnQFMi8pGAk4EaYEKiuhZbU2gk0Mz_P1OueTPD59Mrjoxnu_Dhg6tbfBYF3rBt0hKJaJjAEDLiP69AfduYNv4nWKxb0F0CKHSA0vlPEuBI-Var3da39UFNTJdRVdV2fXIzu-sN-2xuP_oJot5peJH2_vgV0</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Gül, Ceren</creator><creator>Kilic, Sevilay</creator><creator>Şehitoğlu, Müşerref Hilal</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202209</creationdate><title>The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis</title><author>Gül, Ceren ; Kilic, Sevilay ; Şehitoğlu, Müşerref Hilal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2609-c7e3091e55bed329703d7d4af078d10c70e45cd017f5a7fbc524c388bb8348b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Pathogenesis</topic><topic>Psoriasis</topic><topic>Serum levels</topic><topic>Skin diseases</topic><topic>Statistical analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gül, Ceren</creatorcontrib><creatorcontrib>Kilic, Sevilay</creatorcontrib><creatorcontrib>Şehitoğlu, Müşerref Hilal</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gül, Ceren</au><au>Kilic, Sevilay</au><au>Şehitoğlu, Müşerref Hilal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis</atitle><jtitle>Clinical and experimental dermatology</jtitle><date>2022-09</date><risdate>2022</risdate><volume>47</volume><issue>9</issue><spage>1673</spage><epage>1678</epage><pages>1673-1678</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><abstract>Background
Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation and neoangiogenesis. The disease pathogenesis has not been fully elucidated. The proteins, a disintegrin and metalloproteinase (ADAM)10 and ADAM17, are important proteases serving as regulators of inflammation.
Aim
To determine the role of ADAM10 and ADAM17 in the pathogenesis of psoriasis through the comparison of their serum levels in patients with psoriasis and healthy controls (HCs).
Methods
In total, 179 participants (90 patients with psoriasis and 89 HCs) were enrolled in the study. Levels of ADAM10 and ADAM17 in serum were measured by ELISA for each participant from the patient and HC groups. The statistical data analysis was performed using SPSS (V19.0) and P < 0.05 was considered statistically significant.
Results
The mean values for serum ADAM10 and ADAM17 were, respectively, 3.1 ± 2.2 and 76.5 ± 31.1 in the psoriasis group and 8.6 ± 3.7 and 29.5 ± 22.4 in the HC group. A statistically significant difference between the patient and HC groups was detected for both ADAM10 and ADAM17 levels (P = 0.001).
Conclusion
Considering the high levels of ADAM17 in the psoriasis group, ADAM17 protease might have a crucial role in the pathogenesis of psoriasis, while the low levels of ADAM10 might be attributable to its regulatory effect on keratinocyte differentiation and proliferation.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1111/ced.15239</doi><tpages>1678</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-6938 |
| ispartof | Clinical and experimental dermatology, 2022-09, Vol.47 (9), p.1673-1678 |
| issn | 0307-6938 1365-2230 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2656202037 |
| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Pathogenesis Psoriasis Serum levels Skin diseases Statistical analysis |
| title | The importance of a disintegrin and metalloproteinase (ADAM)10 and ADAM17 in the pathogenesis of psoriasis |
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