Hedgehog signaling orchestrates cartilage-to-bone transition independently of Smoothened

•A transient shutdown of Hedgehog signaling is essential to the cartilage-to-bone transition.•Constitutive activation of Hedgehog signaling unleashes a robust cartilage-to-bone transition.•There exists a novel HH signaling transduction in regulating cartilage-to-bone transition, which was independen...

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Veröffentlicht in:	Matrix biology 2022-06, Vol.110, p.76-90
Hauptverfasser:	Wang, Huanbo, Zheng, Chao, Lu, Weiguang, He, Ting, Fan, Jing, Wang, Cheng, Jie, Qiang, Chan, Danny, Cheah, Kathryn Song Eng, Yang, Liu
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone overgrowths Bone turnover Cartilage Cartilage-to-bone transition Chondrocytes Chondrogenesis Hedgehog protein Hedgehog signaling Homeostasis Lineage tracing Osteoblastogenesis Osteoblasts Osteocytes Osteodifferentiation Transcriptomes
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