Enhancement of the Antifungal Activity of Chitinase by Palmitoylation and the Synergy of Palmitoylated Chitinase with Amphotericin B

Combinations of antifungal drugs can have synergistic antifungal activity, achieving high therapeutic efficacy while minimizing the side effects. Amphotericin B (AMB) has been used as a standard antifungal drug for fungal infections; however, because of its high toxicity, new strategies to minimize...

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Veröffentlicht in:	ACS infectious diseases 2022-05, Vol.8 (5), p.1051-1061
Hauptverfasser:	Santoso, Pugoh, Minamihata, Kosuke, Ishimine, Yugo, Taniguchi, Hiromasa, Komada, Takuya, Sato, Ryo, Goto, Masahiro, Takashima, Tomoya, Taira, Toki, Kamiya, Noriho
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - pharmacology Antifungal Agents - chemistry Chitin Chitinases - chemistry Chitinases - metabolism Humans Lipoylation Mycoses - drug therapy Palmitic Acid
Online-Zugang:	Volltext
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