Lentiviral expression of calpain-1 C2-like domain peptide prevents glutamate-induced cell death in mouse hippocampal neuronal HT22 cells

Glutamate neurotoxicity is involved in neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. Excess glutamate causes caspase-independent programmed cell death via oxidative stress and calcium influx. Our previous study showed that calpain-1 localizes to both the cytoplasm and m...

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Veröffentlicht in:	In vitro cellular & developmental biology. Animal 2022-04, Vol.58 (4), p.289-294
Hauptverfasser:	Oikawa, Takenori, Fukuda, Tomokazu, Yamashita, Tetsuro, Tomita, Hiroshi, Ozaki, Taku
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animal models Apoptosis Apoptosis-inducing factor Biomedical and Life Sciences Calcium influx Calpain Caspase Cell Biology Cell Culture Cell death Cytoplasm Deoxyribonucleic acid Developmental Biology DNA DNA fragmentation Fragmentation Gene therapy Hippocampus Life Sciences Mitochondria Mortality Neurodegenerative diseases Neurotoxicity Nuclear transport Oxidative stress Peptides Retinitis Retinitis pigmentosa Stem Cells Tat protein Translocation
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