Synthesis and cholinesterase inhibitory activity study of Amaryllidaceae alkaloid analogues with N -methyl substitution

Polycyclic compounds with -methyl substitution, structurally related to Amaryllidaceae alkaloids, have been synthesised, together with their analogues bearing a quaternary nitrogen atom. To prevent the lone electron pair of the nitrogen from interfering with the reaction sequence, two approaches to...

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Veröffentlicht in:	Organic & biomolecular chemistry 2022-05, Vol.20 (19), p.3960-3966
Hauptverfasser:	Jansa, Petr, Barvík, Ivan, Hulcová, Daniela, Matoušová, Eliška
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Alkaloids Amaryllidaceae Cholinesterase Ligands Molecular docking N-Oxides Nitrogen Oxidation Polycyclic compounds Substitution reactions
Online-Zugang:	Volltext
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