STAT5B restrains human B-cell differentiation to maintain humoral immune homeostasis

Lymphocyte differentiation is regulated by coordinated actions of cytokines and signaling pathways. IL-21 activates STAT1, STAT3, and STAT5 and is fundamental for the differentiation of human B cells into memory cells and antibody-secreting cells. While STAT1 is largely nonessential and STAT3 is cri...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of allergy and clinical immunology 2022-10, Vol.150 (4), p.931-946
Hauptverfasser:	Pelham, Simon J., Caldirola, Maria Soledad, Avery, Danielle T., Mackie, Joseph, Rao, Geetha, Gothe, Florian, Peters, Timothy J., Guerin, Antoine, Neumann, David, Vokurkova, Doris, Hwa, Vivian, Zhang, Wenming, Lyu, Shu-Chen, Chang, Iris, Manohar, Monali, Nadeau, Kari C., Gaillard, Maria Isabel, Bezrodnik, Liliana, Iotova, Violeta, Zwirner, Norberto Walter, Gutierrez, Mavel, Al-Herz, Waleed, Goodnow, Christopher C., Vargas-Hernández, Alexander, Forbes Satter, Lisa R., Hambleton, Sophie, Deenick, Elissa K., Ma, Cindy S., Tangye, Stuart G.
Format:	Artikel
Sprache:	eng
Schlagworte:	CD21lo B cells Cell Differentiation Cytokines - metabolism Homeostasis Human B-cell differentiation Humans IL-21 immune dysregulation immunoglobulin class switching Immunoglobulin Isotypes - metabolism inborn errors of immunity plasma cell generation RNA STAT5 Transcription Factor - genetics STAT5 Transcription Factor - metabolism STAT5B
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!