Development of a transient inline spiking system for evaluating virus clearance in continuous bioprocessing—Proof of concept for virus filtration

The development of continuous/connected bioprocesses requires new approaches for viral clearance validation, both for specific unit operations and for the overall process. In this study, we have developed a transient inline spiking system that can be used to evaluate virus clearance at distinct time...

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Veröffentlicht in:	Biotechnology and bioengineering 2022-08, Vol.119 (8), p.2134-2141
Hauptverfasser:	Malakian, Anna, Jung, Seon Yeop, Afzal, Mohammad A., Carbrello, Christina, Giglia, Sal, Johnson, Matthew, Miller, Corinne, Rayfield, William, Boenitz, Dave, Cetlin, David, Zydney, Andrew L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioprocessing Clearances continuous bioprocessing Evaluation Filtration Fluorescence Leukemia Prefilters Residence time distribution Spiking validation virus clearance virus filtration Viruses Xenotropic
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